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Method for treating lupus by administering an anti-IL-12 antibody
US11078267B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11078267-B2 |
| Application number | US-201916677120-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 7, 2019 |
| Priority date | Aug 7, 2000 |
| Publication date | Aug 3, 2021 |
| Grant date | Aug 3, 2021 |
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- Title
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Abstract
Official abstract text for this publication.
Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as systemic lupus erythematosus.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for reducing symptoms of systemic lupus erythematosus in an animal, comprising administering to said animal (i) a composition comprising an effective amount of an isolated anti-IL-12 antibody comprising a heavy chain variable region of the amino acid sequence of SEQ ID NO: 7 and a light chain variable region of the amino acid sequence of SEQ ID NO: 8, and (ii) a composition comprising an effective amount of an anti-rheumatic. 2. The method of claim 1 , wherein said effective amount of antibody is 0.001-50 mg/kilogram of said animal. 3. A method for reducing symptoms of systemic lupus erythematosus in an animal, comprising administering to said animal (i) a composition comprising an effective amount of an isolated anti-IL-12 antibody comprising a heavy chain complementarity determining region CDR 1 of the amino acid sequence of SEQ ID NO: 1, a heavy chain CDR2 of the amino acid sequence of SEQ ID NO: 2, a heavy chain CDR3 of the amino acid sequence of SEQ ID NO: 3, a light chain CDR1 of the amino acid sequence of SEQ ID NO: 4, a light chain CDR2 of the amino acid sequence of SEQ ID NO: 5, and a light chain CDR3 of the amino acid sequence of SEQ ID NO: 6, and (ii) a composition comprising an effective amount of an anti-rheumatic. 4. The method of claim 3 , wherein said effective amount of antibody is 0.001-50 mg/kilogram of said animal.
Assignees
Inventors
Classifications
Antipsoriatics · CPC title
against proteinaceous materials, e.g. enzymes, hormones, lymphokines · CPC title
Muscle relaxants, e.g. for tetanus or cramps · CPC title
Antagonist effect on antigen, e.g. neutralization or inhibition of binding · CPC title
comprising antibodies · CPC title
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Frequently asked questions
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- What does patent US11078267B2 cover?
- Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as systemic lupus erythematosus.
- Who is the assignee on this patent?
- Janssen Biotech Inc
- What technology area does this patent fall under?
- Primary CPC classification C07K16/244. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 03 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).