ROR γ modulators

Patent metadata

Field	Value
Publication number	US-11078186-B2
Application number	US-201716348195-A
Country	US
Kind code	B2
Filing date	Nov 8, 2017
Priority date	Nov 10, 2016
Publication date	Aug 3, 2021
Grant date	Aug 3, 2021

Abstract

There are described RORγ modulators of the formula (I),

or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.

First claim

What is claimed is:

1. A compound, or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein the compound is selected from the group consisting of:

2. A pharmaceutical composition comprising one or more compounds according to claim 1 , and a pharmaceutically acceptable carrier or diluent.

3. A method of treating a disease or disorder selected from an autoimmune disease or disorder, asthma, an allergic disease or disorder, a metabolic disease or disorder, and cancer in a subject, the method comprising administering to the subject a therapeutically-effective amount of a compound according to claim 1 .

4. The method of claim 3 wherein the autoimmune disease or disorder is selected from psoriasis, rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, acute graft-versus-host disease, psoriatic arthritis, ankylosing spondylitis and multiple sclerosis.

Assignees

• Bristol Myers Squibb Co

Inventors

• Duan Jingwu
• Jiang Bin
• Dhar T G Murali
• Lu Zhonghui
• Gupta Arun Kumar
• Karmakar Ananta

Classifications

• C07D401/14 Primary

  containing three or more hetero rings · CPC title

• C07D403/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• A61P19/02

  for joint disorders, e.g. arthritis, arthrosis · CPC title

• A61P37/00

  Drugs for immunological or allergic disorders · CPC title

• C07D407/12

  linked by a chain containing hetero atoms as chain links · CPC title