Compositions and methods for the treatment of irritable bowel syndrome

Patent metadata

Field	Value
Publication number	US-11078154-B2
Application number	US-201716323069-A
Country	US
Kind code	B2
Filing date	Apr 19, 2017
Priority date	Aug 11, 2016
Publication date	Aug 3, 2021
Grant date	Aug 3, 2021

Abstract

The disclosures herein provide compounds of formula Ior its pharmaceutical acceptable salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, suppository, transdermal, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of irritable bowel syndrome (IBS), inflammatory bowel diseases or its associated complications.

First claim

The invention claimed is:

1. A compound of Formula I:

or pharmaceutically acceptable salts, hydrates, solvates, enantiomers, or stereoisomers thereof;

wherein,
R 1 , R 3 , R 5 each independently represents NULL,

R 2 , R 4 , R 5 each independently represents

2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

3. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from the group consisting of:

and

Assignees

• Cellix Bio Private Ltd

Inventors

• Kandula Mahesh

Classifications

• C07D213/75

  Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates · CPC title

• C07D207/12

  Oxygen or sulfur atoms · CPC title

• C07C233/55 Primary

  having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton · CPC title

• C07C229/60 Primary

  with amino and carboxyl groups bound in meta- or para- positions · CPC title

• C07C229/14

  to carbon atoms of carbon skeletons containing rings · CPC title