Heart-protective plant preparation for preventing and improving coronary heart disease

Patent metadata

Field	Value
Publication number	US-11077162-B2
Application number	US-202017120162-A
Country	US
Kind code	B2
Filing date	Dec 12, 2020
Priority date	Dec 11, 2018
Publication date	Aug 3, 2021
Grant date	Aug 3, 2021

Abstract

The present disclosure provides a natural plant preparation, including extracts of the following parts of plants: roots of Salvia miltiorrhiza Bunge, Juglans regia, Aesculus hippocastanum L. and Zingiber officinale Rosc., barks of Cinnamomum cassia Presl, seeds of Sesamum indicum, Carica papaya L., Nigella damascena L. and Punica granatum L., leaves of Centaurea cyanus L., resin of Pistacia Lentiscus, drupes of Cocos nucifera L., beans of Theobroma cacao L., dried pulp and kernels of Phoenix dactylifera L., dried pulp of Olea europaea, Ficus carica Linn., Walnut and Vaccinium Spp, cloves of Allium sativum, and petals of Rosa sp. The present disclosure further provides a method for preparing a plant preparation, including treating the above parts of plants with ethanol.

First claim

The invention claimed is:

1. A plant preparation, comprising in an oral dosage form therapeutically effective amounts of ethanol extracts of following parts of plants:
roots of Salvia miltiorrhiza Bunge, Juglans regia, Aesculus hippocastanum L. and Zingiber officinale Rosc., barks of Cinnamomum cassia Presl, seeds of Sesamum indicum, Carica papaya L., Nigella damascena L. and Punica granatum L., leaves of Centaurea cyanus L., resin of Pistacia Lentiscus , drupes of Cocos nucifera L., beans of Theobroma cacao L., dried pulp and kernels of Phoenix dactylifera L., dried pulp of Olea europaea, Ficus carica Linn., walnut, and Vaccinium Spp, cloves of Allium sativum , and petals of Rosa sp.

2. The plant preparation according to claim 1 , comprising:
15-25 parts by weight of roots of Salvia miltiorrhiza Bunge,
5-15 parts by weight of roots of Juglans regia,
15-25 parts by weight of roots of Aesculus hippocastanum L.,
5-15 parts by weight of roots of Zingiber officinale Rosc.,
5-15 parts by weight of barks of Cinnamomum cassia Presl,
5-15 parts by weight of seeds of Sesamum indicum,
5-15 parts by weight of seeds of Carica papaya L.,
15-25 parts by weight of seeds of Nigella damascena L.,
5-15 parts by weight of seeds of Punica granatum L.,
15-25 parts by weight of leaves of Centaurea cyanus L.,
5-15 parts by weight of resin of Pistacia Lentiscus,
5-15 parts by weight of drupes of Cocos nucifera L.,
5-15 parts by weight of beans of Theobroma cacao L.,
5-15 parts by weight of dried pulp of Phoenix dactylifera L.,
5-15 parts by weight of kernels of Phoenix dactylifera L.,
5-15 parts by weight of dried pulp of Olea europaea,
5-15 parts by weight of dried pulp of Ficus carica Linn.,
5-15 parts by weight of walnut,
5-15 parts by weight of dried pulp of Vaccinium spp,
5-15 parts by weight of cloves of Allium sativum , and
5-15 parts by weight of petals of Rosa sp.

3. The plant preparation according to claim 2 , comprising the ethanol extracts of the following parts of plants:
20 parts by weight of roots of Salvia miltiorrhiza Bunge,
10 parts by weight of roots of Juglans regia,
20 parts by weight of roots of Aesculus hippocastanum L.,
10 parts by weight of roots of Zingiber officinale Rosc.,
10 parts by weight of barks of Cinnamomum cassia Presl,
10 parts by weight of seeds of Sesamum indicum,
10 parts by weight of seeds of Carica papaya L.,
20 parts by weight of seeds of Nigella damascena L.,
10 parts by weight of seeds of Punica granatum L.,
20 parts by weight of leaves of Centaurea cyanus L.,
10 parts by weight of resin of Pistacia Lentiscus,
10 parts by weight of drupes of Cocos nucifera L.,
10 parts by weight of beans of Theobroma cacao L.,
10 parts by weight of dried pulp of Phoenix dactylifera L.,
10 parts by weight of kernels of Phoenix dactylifera L.,
10 parts by weight of dried pulp of Olea europaea,
10 parts by weight of dried pulp of Ficus carica Linn.,
10 parts by weight of walnut,
10 parts by weight of dried pulp of Vaccinium Spp,
10 parts by weight of cloves of Allium sativum , and
10 parts by weight of petals of Rosa sp.

4. The plant preparation according to claim 1 , wherein the plant preparation is formulated into a dosage form selected from the group consisting of powders, capsules, tablets, granules, pills, and lozenges.

5. A method for preparing a plant preparation according to claim 1 , the method comprising the steps of:
providing parts of plants comprising roots of Salvia miltiorrhiza Bunge, Juglans regia, Aesculus hippocastanum L. and Zingiber officinale Rosc., barks of Cinnamomum cassia Presl, seeds of Sesamum indicum, Carica papaya L., Nigella damascena L. and Punica granatum L., leaves of Centaurea cyanus L., resin of Pistacia Lentiscus , drupes of Cocos nucifera L., beans of Theobroma cacao L., dried pulp and kernels of Phoenix dactylifera L., dried pulp of Olea europaea, Ficus carica Linn., walnut, and Vaccinium Spp, cloves of Allium sativum , and petals of Rosa sp.
treating the parts of the plants, at 70-80° C., with ethanol, and
maintaining pH of the resulting solution between pH 7 and pH 10.

6. The method according to claim 5 , wherein the ethanol is 60-80 vol % ethanol or 70 vol % ethanol.

7. The method according to claim 5 , wherein the provided parts of plants are in powder form.

8. The method according to claim 5 , wherein the duration for treating the parts of plants with ethanol is 16-20 h.

9. The method according to claim 5 , further comprising a drying step to remove the organic solvents and/or provide the plant preparation as a dried plant preparation.

10. The method according to claim 5 , wherein the drying step comprises drying by a hot air oven to evaporate organic solvents followed by freeze drying.

Assignees

• Univ Shandong Technology

Inventors

• Song Yuanda
• Ammar Syed
• Li Shaoqi
• Yang Wu

Classifications

• A61K36/5777

  Theobroma, e.g. cocao or cocoa · CPC title

• A61K36/185

  Magnoliopsida (dicotyledons) · CPC title

• A61P3/08 Primary

  for glucose homeostasis (pancreatic hormones A61P5/48) · CPC title

• A61P25/22

  Anxiolytics · CPC title

• A61P9/14

  Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers · CPC title