Apparatus for changing the refractive power of the cornea

Patent metadata

Field	Value
Publication number	US-11076994-B2
Application number	US-201716306228-A
Country	US
Kind code	B2
Filing date	May 31, 2017
Priority date	May 31, 2016
Publication date	Aug 3, 2021
Grant date	Aug 3, 2021

Abstract

The invention relates to an apparatus for changing the refractive power of the cornea ( 1 ), in particular for correcting hyperopia or presbyopia, exhibiting injection means ( 13, 15 ) having at least one hollow needle ( 15 ) for injecting at least one optically transparent filling material having a predetermined refractive index into an intrastromal corneal pocket ( 7 ), characterized by a controllable injection drive ( 17 ) that is coupled at least indirectly to the injection means ( 13, 15 ) and is designed for changing an amount, to be injected, of the at least one filling material; a device for optical coherence tomography (OCT) ( 19 ) that is designed for monitoring the area of the corneal pocket ( 7 ) by means of measurement of depth profiles of the cornea ( 1 ) on a repeatedly cycled-through scan pattern; and a computing unit ( 21 ) that is designed and/or configured to determine from the measurement data of the OCT device ( 19 ) at least the radius of curvature of the front ( 3 ) of the cornea ( 1 ) keeping pace temporally with the repetitions of the scan pattern cycle during the injection, wherein the computing unit ( 21 ) is designed and/or configured to control the injection drive ( 17 ) for changing the injected amount of the at least one filling material, and namely on the basis of the radius of curvature of the front ( 3 ) of the cornea ( 1 ) and/or such until a predetermined target criterion is fulfilled.

First claim

The invention claimed is:

1. A system for changing a refractive power of a cornea, comprising
an injection system having at least one hollow needle arranged to inject at least one optically transparent filling material having a predetermined refractive index into an intrastromal pocket in the cornea having the refractive power;
a computing unit;
a controllable injection drive coupled directly or indirectly to the injection system and to the computing unit, wherein the injection drive is controlled by the computing unit to adjust an amount to be injected of the at least one filling material; and
a device for optical coherence tomography (OCT) arranged to monitor an area of the corneal pocket by measuring depth profiles of the cornea to produce measurement data and to transmit the measurement data to the computing unit;
wherein the computing unit is arranged and configured to determine from the measurement data of the OCT device at least a radius of curvature of a front surface of the cornea, and
wherein the computing unit is arranged and configured to control the injection drive to adjust an injected amount of the at least one filling material based on the radius of curvature of the front of the cornea until a predetermined first target criterion is fulfilled.

2. The system of claim 1 , further comprising the optically transparent filling material, wherein the predetermined refractive index of the filling material substantially coincides with a refractive index of stromal tissue of the cornea and wherein the computing unit is arranged and configured to compute the refractive power of the cornea as that of a convex-concave lens based on at least the determined radius of curvature of the front surface of the cornea.

3. The system of claim 2 , wherein the computing unit is configured to check a coincidence of the computed refractive power of the cornea with a predetermined desired value as a second target criterion.

4. The system of claim 1 , wherein the computing unit is arranged and configured to determine from the measurement data of the OCT device a travel of the corneal pocket along an optical axis of the cornea and radii of curvature of front and rear limiting faces of the corneal pocket keeping pace temporally with repetitions of a scan pattern cycle.

5. The system of claim 4 , wherein the computing unit is arranged and configured to check a coincidence of the computed refractive power of the cornea with a predetermined desired value as a third target criterion.

6. The system of claim 1 , wherein grid points of a two-dimensional grid in a plane at right angles to an optical axis are predetermined as a scan pattern of the OCT device.

7. The system of claim 6 , wherein the computing unit is arranged and configured to compute from the measurement data of the OCT device a three-dimensional model of a shape of the cornea and of the corneal pocket filled with the filling material.

8. The system of claim 7 , wherein the computing unit is arranged and configured to keep pace temporally with a model computation, to determine astigmatism of an optical system formed by the cornea and the filled corneal pocket and to represent the optical system as a tuple of parameters.

9. The system of claim 8 , wherein the computing unit is arranged and configured to check convergence of an actual-value tuple toward a predetermined desired-value tuple in terms of a minimum distance as a third target criterion.

10. The system of claim 9 , wherein the computing unit is arranged and configured to compute from the actual-value tuple during fulfillment of the third target criterion and from the predetermined desired-value tuple at which edge positions the corneal pocket is to be opened up further to reduce a remaining distance between the actual-value tuple and the predetermined desired-value tuple.

11. The system of claim 10 , wherein the computing unit is arranged and configured to output at which edge positions the corneal pocket is to be opened up further to reduce the remaining distance between the actual-value tuple and the desired-value tuple.

12. The system of claim 1 , wherein the system is arranged and configured to correct hyperopia or presbyopia.

13. The system of claim 1 , wherein the OCT device is controlled to provide a repeatedly cycled-through scan pattern, and wherein the computing unit is further configured to keep pace temporally with repetitions of the repeatedly cycled-through scan pattern during an injection.

Assignees

• Massachusetts Gen Hospital

Inventors

• Vogel Alfred
• Linz Norbert
• Freidank Sebastian
• Birngruber Reginald

Classifications

• A61F2/147 Primary

  Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants · CPC title

• A61F2/148

  Implantation instruments specially adapted therefor · CPC title

• A61F2240/002

  Designing or making customized prostheses · CPC title

• A61B3/107

  for determining the shape or measuring the curvature of the cornea · CPC title

• A61F9/0017

  implantable in, or in contact with, the eye, e.g. ocular inserts · CPC title