Hemostatic sponge

Patent metadata

Field	Value
Publication number	US-11071804-B2
Application number	US-201715843338-A
Country	US
Kind code	B2
Filing date	Dec 15, 2017
Priority date	Dec 16, 2009
Publication date	Jul 27, 2021
Grant date	Jul 27, 2021

Abstract

The present invention provides a hemostatic composite sponge comprising oxidized cellulose and an essentially gelatin-free bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.

First claim

What is claimed is:

1. A hemostatic porous sponge comprising a matrix of oxidized cellulose and a bioadhesive material stably associated with at least one surface of said porous sponge, wherein said bioadhesive material is free of gelatin, said bioadhesive material is present in a range of 2 to 5 mg/cm 2 of the oxidized cellulose, and said bioadhesive material is present in a grid pattern on the porous sponge.

2. The sponge according to claim 1 , wherein the bioadhesive material is selected from the group consisting of polyethylene glycol, derivatives of polyethylene glycol, and combinations thereof.

3. The sponge according to claim 1 , wherein the bioadhesive material is reactive polyethylene glycol.

4. The sponge according to claim 1 , wherein the bioadhesive material comprises multiple reactive polyethylene glycols.

5. The sponge according to claim 1 , wherein the grid pattern forms a continuous layer on the surface of the sponge.

6. The sponge according to claim 1 , wherein the bioadhesive material comprises a mixture of two pre-polymers comprising a first cross-linkable component and a second cross-linkable component that cross-links with the first cross-linkable component under reaction enabling conditions, and the second cross-linkable component comprises a polyethylene glycol (PEG) having two or more succinimidyl groups.

7. A hemostatic porous sponge comprising a matrix of oxidized cellulose and a material enhancing the adherence of said sponge to an applied tissue stably associated with at least one surface of said porous sponge, wherein said adherence-enhancing material is essentially free of gelatin, said adherence-enhancing material is present in a range of 2 to 5 mg/cm 2 of the oxidized cellulose, and the adherence-enhancing material is present in a grid pattern on the porous sponge.

8. The sponge according to claim 7 , wherein the adherence-enhancing material is selected from the group consisting of polyethylene glycol, derivatives of polyethylene glycol, and combinations thereof.

9. The sponge according to claim 8 , wherein the sponge comprises multiple polymers.

10. The sponge according to claim 7 , wherein the adherence-enhancing material is reactive polyethylene glycol.

11. The sponge according to claim 7 , wherein the adherence-enhancing material comprises multiple reactive polyethylene glycols.

12. The sponge according to claim 7 , wherein the grid pattern forms a continuous layer on the surface of the sponge.

13. The sponge according to claim 7 , wherein the adherence-enhancing material comprises a mixture of two pre-polymers comprising a first cross-linkable component and a second cross-linkable component that cross-links with the first cross-linkable component under reaction enabling conditions, and the second cross-linkable component comprises a polyethylene glycol (PEG) having two or more succinimidyl groups.

14. A hemostatic porous sponge comprising a matrix of oxidized cellulose and a gelatin-free material enhancing the adherence of said sponge to an applied tissue stably associated with at least one surface of said porous sponge, wherein said gelatin-free material is present in a range of 2 to 5 mg/cm 2 of the oxidized cellulose, wherein the gelatin-free material is present in an organized pattern on the porous sponge.

15. The sponge according to claim 14 , wherein the gelatin-free material is selected from the group consisting of polyethylene glycol, derivatives of polyethylene glycol, and combinations thereof.

16. The sponge according to claim 14 , wherein the gelatin-free material is reactive polyethylene glycol.

17. The sponge according to claim 14 , wherein the gelatin-free material comprises multiple reactive polyethylene glycols.

18. The sponge according to claim 14 , wherein the organized pattern forms a continuous layer on the surface of the sponge.

19. The sponge according to claim 14 , wherein the sponge comprises multiple polymers.

20. The sponge according to claim 14 , wherein the gelatin-free material comprises a mixture of two pre-polymers comprising a first cross-linkable component and a second cross-linkable component that cross-links with the first cross-linkable component under reaction enabling conditions, and the second cross-linkable component comprises a polyethylene glycol (PEG) having two or more succinimidyl groups.

Assignees

• Baxter Int
• Baxter Healthcare Sa

Inventors

• Hedrich Hans Christian
• Hoefinghoff Joris
• Rhee Woonza M
• Osawa Atsushi Edward

Classifications

• C08L71/02

  Polyalkylene oxides · CPC title

• A61L2400/04

  Materials for stopping bleeding · CPC title

• C08G65/334

  containing sulfur · CPC title

• A61F2013/00463

  haemostatic · CPC title

• A61F13/15577

  Apparatus or processes for manufacturing · CPC title