Release of ClO2 gas from medical device packaging film

Patent metadata

Field	Value
Publication number	US-11071801-B2
Application number	US-201715433510-A
Country	US
Kind code	B2
Filing date	Feb 15, 2017
Priority date	Aug 18, 2015
Publication date	Jul 27, 2021
Grant date	Jul 27, 2021

Abstract

A multilayer medical packaging film includes a first layer and a chlorine dioxide-producing layer. The chlorine dioxide-producing layer includes a polymer composition and a plurality of chlorite ions. The chlorine dioxide-producing layer is substantially free of an energy-activated catalyst and is substantially free of an acid-releasing compound. However, the film is capable of generating chlorine dioxide when exposed to UV light and moisture.

First claim

We claim:

1. A multilayer medical packaging film comprising:
a first layer, and
a chlorine dioxide-producing layer comprising a polymer composition and a source of a plurality of chlorite ions;
wherein the chlorine dioxide-producing layer comprises less than 2% by weight of an energy-activated catalyst and comprises no acid-releasing compound, wherein the weight ratio of the energy-activated catalyst to the source of the plurality of chlorite ions is 1:20 or less, and
wherein the chlorine dioxide-producing layer produces a sufficient amount of chlorine dioxide when exposed to UV light and moisture to disinfect or sterilize a medical device packaged in the film.

2. The multilayer medical packaging film according to claim 1 , wherein the source of the plurality of chlorite ions comprises a salt selected from the group consisting of sodium chlorite, potassium chlorite, and mixtures thereof.

3. The multilayer medical packaging film according to claim 1 , wherein the first layer is an oxygen barrier layer; wherein the oxygen barrier layer comprises aluminum foil, metal coated polymer, metal oxide coated polymer, or an aromatic polyamide polymer.

4. The multilayer medical packaging film according to claim 1 , wherein the first layer is an oxygen barrier layer; wherein the oxygen barrier layer comprises ethylene vinyl alcohol copolymer, polyvinylidene chloride copolymer, or an aliphatic polyamide.

5. The multilayer medical packaging film according to claim 1 , wherein the chlorine-dioxide-producing layer is a coating having a thickness less than 15 μm.

6. The multilayer medical packaging film according to claim 5 , wherein the polymer composition comprises at least one of polyethylene, ethylene vinyl acetate, ethylene alpha-olefins, or polypropylene.

7. The multilayer medical packaging film according to claim 5 , wherein the source of the plurality of chlorite ions comprises a salt, and the salt is present in an amount within a range from 0.1 weight percent to 30 weight percent relative to the total weight of the chlorine dioxide-producing layer.

8. The multilayer medical packaging film according to claim 5 , wherein the source of the plurality of chlorite ions comprises a salt, and the salt is present in an amount within a range from 10 weight percent to 20 weight percent relative to the total weight of the chlorine dioxide-producing layer.

9. The multilayer medical packaging film according to claim 1 , wherein the chlorine dioxide-producing layer has a thickness of at least 25 μm.

10. The multilayer medical packaging film according to claim 9 , wherein the polymer composition comprises at least one of polyethylene, ethylene vinyl acetate, ethylene alpha-olefins, or polypropylene.

11. The multilayer medical packaging film according to claim 9 , wherein the source of the plurality of chlorite ions comprises a salt, wherein the salt is present in an amount within a range from 0.1 weight percent to 25 weight percent relative to the total weight of the chlorine dioxide-producing layer.

12. The multilayer medical packaging film according to claim 9 , wherein the source of the plurality of chlorite ions comprises a salt, wherein the salt is present in an amount within a range from 5 weight percent to 20 weight percent relative to the total weight of the chlorine dioxide-producing layer.

13. The multilayer medical packaging film according to claim 1 , wherein the first layer is an outer layer proximate the chlorine dioxide-producing layer, wherein the outer layer comprises at least one of polyethylene or polypropylene.

14. The multilayer medical packaging film according to claim 1 , wherein the first layer is an abuse-resistant layer, wherein the abuse-resistant layer is UV-light transparent.

15. The multilayer medical packaging film according to claim 1 , wherein the film has a layer composition in the following sequence:
a layer of polyethylene;
the chlorine dioxide-producing layer;
a tie layer;
the first layer comprising an oxygen barrier layer;
a tie layer; and
an abuse layer,

wherein optional additional layers may be dispersed within said sequence.

16. A medical package comprising a sidewall comprising the multilayer medical packaging film according to claim 1 , wherein the medical package comprises an interior volume defined by an inside surface of the sidewall.

17. The medical package according to claim 16 , wherein the chlorine dioxide-producing layer is proximate the inside surface of the sidewall.

18. The medical package according to claim 16 , wherein the chlorine dioxide-producing layer has a surface area smaller than the inside surface of the sidewall.

19. The multilayer medical packaging film of claim 1 , wherein the chlorine dioxide-producing layer comprises no energy-activated catalyst.

Assignees

• Wisconsin Alumni Res Found
• Bemis Co Inc

Inventors

• Abbott Nicholas
• Jain Rishabh
• Nelson Kevin
• Busche David
• Lynn David

Classifications

• B01J19/123 Primary

  Ultraviolet light · CPC title

• A61L2/20 Primary

  Gaseous substances, e.g. vapours · CPC title

• B32B2439/06

  Bags, sacks, sachets · CPC title

• B65D1/00

  Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material (with curved or partially-curved cross-section made by winding or bending paper B65D3/00; with polygonal cross-section formed by folding B65D5/00; specially constructed to be opened by cutting, piercing or tearing of wall portions B65D17/00; rigid pallets with side walls B65D19/02) · CPC title

• B32B27/322

  comprising halogenated polyolefins, e.g. PTFE · CPC title