Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
US-9463247-B2 · Oct 11, 2016 · US
Biodegradable lipids for the delivery of active agents
US11071784B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11071784-B2 |
| Application number | US-201916520183-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 23, 2019 |
| Priority date | Dec 7, 2011 |
| Publication date | Jul 27, 2021 |
| Grant date | Jul 27, 2021 |
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- Title
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Abstract
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The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
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Classifications
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links · CPC title
substituted by singly bound oxygen or sulfur atoms · CPC title
substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title
comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers (lipids as modifying agents {A61K47/543}) · CPC title
Diamines · CPC title
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- What does patent US11071784B2 cover?
- The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggreg…
- Who is the assignee on this patent?
- Alnylam Pharmaceuticals Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K47/18. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jul 27 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).