Photoacoustic measurement apparatus and photoacoustic measurement system

Patent metadata

Field	Value
Publication number	US-11071460-B2
Application number	US-201715639026-A
Country	US
Kind code	B2
Filing date	Jun 30, 2017
Priority date	Jan 8, 2015
Publication date	Jul 27, 2021
Grant date	Jul 27, 2021

Abstract

In a photoacoustic measurement apparatus and a photoacoustic measurement system, it is possible to generate blood flow information using a photoacoustic image without requiring a separate tourniquet. A light source emits measurement light. A probe detects a photoacoustic wave generated in a subject after measurement light is emitted to the subject in each of the avascularized condition in which the subject is avascularized and the non-avascularized condition in which the subject is not avascularized. Photoacoustic image generation unit generates a photoacoustic image based on the detection signal of the photoacoustic wave. Blood flow information generation unit generates blood flow information based on the signal value of a photoacoustic image in a region of interest set in the photoacoustic image. The avascularization of the subject is performed by pressing the probe against the subject.

First claim

What is claimed is:

1. A photoacoustic measurement apparatus, comprising:
a probe that detects a photoacoustic wave generated in a subject by measurement light emitted to the subject;
a grip portion that grips the probe;
a pressure sensor for detecting a contact pressure of the probe with respect to the subject;
a moving mechanism comprising a motor and is driven by the motor that is configured to move the probe in a direction in which the probe is pressed against the subject until the contact pressure representing the subject is avascularized condition based on the contact pressure, and a direction in which the probe is away from the subject until the contact pressure representing the subject is non-avascularized condition through the grip portion; and
a processor configured to:
generate a photoacoustic image based on a detection signal of the photoacoustic wave detected by the probe; and
generate blood flow information based on a signal value of the photoacoustic image in a region of interest set in the photoacoustic image,

wherein the probe detects the photoacoustic wave in each of at least an avascularized condition in which the subject is avascularized by the probe and a non-avascularized condition in which the subject is not avascularized.

2. The photoacoustic measurement apparatus according to claim 1 , further comprising:
a contact pressure control circuit for driving the moving mechanism based on the contact pressure detected by the pressure sensor.

3. The photoacoustic measurement apparatus according to claim 1 ,
wherein the pressure sensor detects the contact pressure at the grip portion.

4. The photoacoustic measurement apparatus according to claim 1 ,
wherein the pressure sensor is provided at the probe.

5. The photoacoustic measurement apparatus according to claim 4 ,
wherein the probe includes a detector element that detects the photoacoustic wave and a light emitting portion that emits the measurement light, and
at least a part of the pressure sensor is provided between the detector element and the light emitting portion.

6. The photoacoustic measurement apparatus according to claim 5 ,
wherein the pressure sensor surrounds the detector element.

7. The photoacoustic measurement apparatus according to claim 4 ,
wherein the pressure sensor is covered with a cover in contact with the subject.

8. The photoacoustic measurement apparatus according to claim 1 ,
wherein the processor is further configured to binarize the signal value by setting the signal value to a first value when the signal value is equal to or greater than a first threshold value and equal to or less than a second threshold value larger than the first threshold value and setting the signal value to a second value different from the first value when the signal value is less than the first threshold value or greater than the second threshold value, and generates the blood flow information based on the binarized signal value.

9. The photoacoustic measurement apparatus according to claim 1 ,
wherein the probe further detects a reflected acoustic wave with respect to an acoustic wave transmitted to the subject,
wherein the processor is further configured to generate a reflected acoustic wave image based on a detection signal of the reflected acoustic wave detected by the probe; and
wherein processor is further configured to track a position of the region of interest using the reflected acoustic wave image.

10. The photoacoustic measurement apparatus according to claim 1 ,
wherein the processor is further configured to generate, as blood flow information, a total value or an average value of the signal value in the region of interest.

11. The photoacoustic measurement apparatus according to claim 10 ,
wherein the processor is further configured to generate a graph showing a relationship between the blood flow information and the contact pressure.

12. The photoacoustic measurement apparatus according to claim 1 ,
wherein the processor is further configured to calculate a total value or an average value of the signal value in the region of interest, and generates, as the blood flow information, a score value based on a difference between a minimum value and a maximum value of the total value or the average value in a certain period.

13. The photoacoustic measurement apparatus according to claim 1 ,
wherein the processor is further configured to generate, as the blood flow information, a score value based on a difference between a total value or an average value of the signal value in the region of interest in the avascularized condition and a total value or an average value of the signal value in the region of interest in the non-avascularized condition.

14. The photoacoustic measurement apparatus according to claim 1 ,
wherein, in a case where the subject is changed from the avascularized condition to the non-avascularized condition by the probe, the processor is further configured to generate, as the blood flow information, a score value based on a time change rate of a total value or an average value of the signal value in the region of interest.

15. The photoacoustic measurement apparatus according to claim 1 ,
wherein, in a case where the subject is changed from the avascularized condition to the non-avascularized condition by the probe, the processor is further configured to generate, as the blood flow information, a score value based on a total value or an average value of the signal value in the region of interest after a certain time has passed from a reference time.

16. The photoacoustic measurement apparatus according to claim 1 ,
wherein, in a case where the subject is changed from the avascularized condition to the non-avascularized condition by the probe, the processor is further configured to generate, as the blood flow information, a score value based on a time from a reference time to a time at which a total value or an average value of the signal value in the region of interest reaches a certain level.

17. The photoacoustic measurement apparatus according to claim 1 ,
wherein the processor is further configured to generate a blood flow information image based on the blood flow information.

18. The photoacoustic measurement apparatus according to claim 17 ,
wherein, in a case where a plurality of the region of interest are set, the blood flow information is generated for each of the plurality of region of interest, and the blood flow information image is a space map image for displaying blood flow information of each region of interest in the region of interest.

19. The photoacoustic measurement apparatus according to claim 18 ,
wherein, in the blood flow information image, each region of interest is displayed with a brightness corresponding to the blood flow information.

20. The photoacoustic measurement apparatus according to claim 18 ,
wherein the processor is further configured to set a display color of each region of interest in the blood flow information image to a different display color in a case where blood flow information at a first time is larger than blood flow information at a second time earlier than the first time and a case where the blood flow information at the first time is smaller than the blood flow information at the second time.

21. The photoacoustic measurement apparatus according to claim 1 ,
wherein a plurality of the region of interest are set in a grid form.

22. A photoacoustic measurement system, compris

Assignees

• Fujifilm Corp

Inventors

• Irisawa Kaku
• Murakoshi Dai
• Ebata Tetsuro
• Hara Shoji

Classifications

• A61B5/6843

  Monitoring or controlling sensor contact pressure · CPC title

• A61B2562/14

  Coupling media or elements to improve sensor contact with skin or tissue · CPC title

• A61B5/026

  Measuring blood flow {(A61B3/1233, A61B3/1241 take precedence)} · CPC title

• A61B5/0095 Primary

  by applying light and detecting acoustic waves, i.e. photoacoustic measurements · CPC title

• A61B8/06

  Measuring blood flow · CPC title