Electro-chemical sensor and coating method, production method and corresponding uses

Patent metadata

Field	Value
Publication number	US-11067528-B2
Application number	US-201616065080-A
Country	US
Kind code	B2
Filing date	Nov 22, 2016
Priority date	Dec 22, 2015
Publication date	Jul 20, 2021
Grant date	Jul 20, 2021

Abstract

The invention relates to an electro-chemical sensor and coating method, production method and corresponding uses. The coating method of an electro-chemical sensor comprises the following steps: coating a carbon-rich substrate, with a carbon content greater than or equal to 0 wt. % in relation to the total weight of the substrate, and with an organic polymer; and applying a cold plasma treatment to said coating. This method permits the production of electro-chemical sensors with a carbon-rich substrate, with a carbon content greater or equal to 50 wt. % in relation to the total weight of the substrate, and a modified organic polymer coating. These new sensors are suitable for the detection of, inter alia, dopamine, glucose, uric acid and ascorbic acid.

First claim

The invention claimed is:

1. An electrochemical sensor coating method, comprising the steps of:
coating a carbon-rich substrate of the electrochemical sensor with an organic low density polyethylene (LDPE) coating, the substrate having a carbon content greater than or equal to 50% by weight with respect to the total weight of the substrate, and
applying a cold plasma treatment to said coating thereby converting at least a portion of the LDPE coating surface into active species of carbon and oxygen,
wherein the carbon-rich substrate is made of a material from the group consisting of graphite, glassy carbon, nanostructured carbons, and fullerenes.

2. The method according to claim 1 , wherein said plasma is an atmospheric plasma, a vacuum plasma, or a corona energy plasma comprising between 0.1 mJ/cm 2 and 100 J/cm 2 in an atmosphere with oxygen, or nitrogen, or another inert gas.

3. The method according to claim 1 , wherein the plasma application time is more than 1 s.

4. The method according to claim 3 , wherein the plasma application time is more than 15 s.

5. The method according to claim 1 , wherein the plasma application time is less than 120 s.

6. The method of claim 1 , wherein the electrochemical sensor is for detection of dopamine, glucose, uric acid or ascorbic acid.

7. The method according to claim 1 , wherein the nanostructured carbons comprise graphene or carbon nanotubes.

8. A production method for producing an electrochemical sensor comprising a carbon-rich substrate with a carbon content greater than or equal to 50% by weight with respect to the total weight of the substrate, wherein the method comprises the steps of claim 1 .

9. An electrochemical sensor, comprising a carbon-rich substrate having a carbon content greater than or equal to 50% by weight with respect to the total weight of the substrate, and an organic low density polyethylene (LDPE) coating deposited on the carbon-rich substrate,
wherein said LDPE coating has been treated by a cold plasma and the treated LDPE coating comprises carbon and oxygen as active species on its surface;
wherein the carbon-rich substrate is made of a material from the group consisting of graphite, glassy carbon, nanostructured carbons, and fullerenes.

10. A method for detecting an analyte selected from the group consisting of dopamine, glucose, uric acid, and ascorbic acid, the method comprising contacting the analyte with the electrochemical sensor of claim 9 .

11. The electrochemical sensor of claim 9 , wherein the electrochemical sensor is for detection of dopamine, glucose, uric acid or ascorbic acid.

12. The electrochemical sensor of claim 9 , wherein cold plasma is atmospheric plasma, air plasma, oxygen plasma, or nitrogen plasma.

Assignees

• Univ Catalunya Politecnica

Inventors

• Armelin Diggroc Elaine
• Fabregat Jové Georgina
• Llorca Pique Jordi
• Alemán Llansó Carlos

Classifications

• G01N33/9413

  Dopamine · CPC title

• G01N33/66

  involving blood sugars, e.g. galactose · CPC title

• G01N33/5308

  for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites · CPC title

• G01N27/308

  at least partially made of carbon · CPC title

• C09D177/00

  Coating compositions based on polyamides obtained by reactions forming a carboxylic amide link in the main chain (based on polyhydrazides C09D179/06; based on polyamide-imides C09D179/08); Coating compositions based on derivatives of such polymers · CPC title