Modulation of neuronal nkcc1 as a therapeutic strategy for spasticity and related disorders
US-2024416127-A1 · Dec 19, 2024 · US
US11065440B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11065440-B2 |
| Application number | US-201715793450-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 25, 2017 |
| Priority date | Jun 26, 2014 |
| Publication date | Jul 20, 2021 |
| Grant date | Jul 20, 2021 |
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A hearing assistance device comprises an implantable part for electrically stimulating an auditory nerve of a user. The implanted part comprises a) a current source generator; and b) an electrode array configured to be located inside one of the cochlear scala or adjacent to the auditory nerve. The hearing assistance device is configured to produce a time-varying waveform delivered by the current source generator, the time-varying waveform comprising a positively sloping positive pulse. This has the advantages of providing a smaller spatial spread of neurons being discharged by electric stimuli from a given electrode. The invention may e.g. be used in cochlear implant hearing assistance devices.
Opening claim text (preview).
The invention claimed is: 1. A hearing assistance device comprising an implantable part for electrically stimulating an auditory nerve of a user, the implantable part comprising a current source generator; an electrode array configured to be located inside one of the cochlear scala or adjacent to the auditory nerve, or at the auditory brainstem; a processor programmed to determine, based on an acoustic input signal picked up by a microphone, a location of the auditory nerve to be stimulated and a spatial range of neurons along the length of the auditory nerve to be excited, calculate a slope of stimulation based on a rate of depolarization associated with the neurons of the auditory nerve and a correlation between the neurons' distances from a stimulation electrode and reductions in slope seen by the neurons, said slope of stimulation being defined as one of: an amount of charge density over time to be delivered to a singular stimulation electrode in said electrode array to stimulate the determined location of the auditory nerve to be stimulated, and an amount of current over time to be delivered to the singular stimulation electrode in said electrode array to stimulate the determined location of the auditory nerve to be stimulated, and cause said current source generator to deliver to the singular stimulation electrode in said electrode array a time-varying waveform comprising a positive pulse having a rising edge and a falling edge, the positive pulse further having a monotonically increasing segment connecting the rising edge and the falling edge such that an entirety of the positive pulse has a positive slope, the height of the falling edge being larger than the height of the rising edge by an amount that causes the monotonically increasing segment to have the calculated slope of stimulation, thereby causing the singular stimulation electrode in said electrode array to stimulate the determined location of the audio nerve in such manner as to provide a focussed neural excitation based on temporal shaping of a stimulating waveform, wherein said processor calculates the slope of stimulation so as not to exceed a discharge threshold for each neuron of the auditory nerve outside the spatial range thereby preventing a discharge that otherwise would occur to at least one neuron of the auditory nerve based on an amplitude of said pulse in order to improve spectral resolution in the sound perception of the user. 2. A hearing assistance device according to claim 1 wherein said time-varying waveform comprises a negatively sloping negative pulse. 3. A hearing assistance device according to claim 2 , wherein the hearing assistance device is a cochlear implant hearing assistance device. 4. A hearing assistance device according to claim 1 wherein the hearing assistance device is configured to dynamically adapt the time-varying waveform to the input signal. 5. A hearing assistance device according to claim 4 , wherein the hearing assistance device is a cochlear implant hearing assistance device. 6. A hearing assistance device according to claim 1 wherein the hearing assistance device is configured to provide that the time-varying waveform stimulation pulse is modulated in width and/or amplitude according to the frequency content of the input signal. 7. A hearing assistance device according to claim 6 , wherein the hearing assistance device is a cochlear implant hearing assistance device. 8. A hearing assistance device according to claim 1 wherein the time-varying waveform comprises a bi-phasic sloping, symmetric waveform stimulation pulse. 9. A hearing assistance device according to claim 8 , wherein the hearing assistance device is a cochlear implant hearing assistance device. 10. A hearing assistance device according to claim 1 , wherein the hearing assistance device is a cochlear implant hearing assistance device.
Cochlear stimulation · CPC title
Cochlear electrodes · CPC title
fitting procedures · CPC title
adapted for a particular treatment · CPC title
Electrodes for brain stimulation · CPC title
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