Medicament packaging

Patent metadata

Field	Value
Publication number	US-11065388-B2
Application number	US-201615739449-A
Country	US
Kind code	B2
Filing date	Jul 13, 2016
Priority date	Jul 13, 2015
Publication date	Jul 20, 2021
Grant date	Jul 20, 2021

Abstract

A cartridge (100) for packaging a medicament and being suitable for use with multiple different types of dosing device is described, together with dosing devices and adaptors for dosing devices. The cartridge includes a generally tubular body (102) having an interior cavity (104), a closure member (106) disposed at a distal end of the body and comprising a sealing element (128), a piston member (108) disposed in the cavity to contain the medicament between the piston member and the sealing element (128), a coupling element (114) disposed at the distal end of the body for coupling the cartridge to a dosing device (200) or to an adaptor for a dosing device, and a seal arrangement (126, 129) for receiving a sealing element release member (214) of the dosing device or adaptor. The coupling element (114) is arranged for engagement with an engagement part (220) of the dosing device or adaptor to clip the cartridge (100) to the dosing device or adaptor (200) upon insertion of the cartridge to the dosing device or adaptor, and the seal arrangement (126, 129) is disposed distally with respect to the sealing element (128) and is arranged to form a seal around the release member (214; 254) when the cartridge is coupled to the dosing device or adaptor.

First claim

The invention claimed is:

1. A cartridge for packaging a medicament, the cartridge being suitable for use with multiple different types of dosing devices and comprising:
a generally tubular body having an interior cavity;
a closure member disposed at a distal end of the body and comprising a sealing element;
a piston member disposed in the cavity to contain the medicament between the piston member and the sealing element;
a coupling element disposed at the distal end of the body for coupling the cartridge to a dosing device or to an adaptor for a dosing device; and
a seal arrangement comprising a passage for receiving a sealing element release member of the dosing device or adaptor,
the passage comprising a sealing surface arranged to form a seal around the release member;

wherein the coupling element is arranged for engagement with an engagement part of the dosing device or adaptor to clip the cartridge to the dosing device or adaptor upon insertion of the cartridge to the dosing device or adaptor;
and wherein the seal arrangement is disposed distally with respect to the sealing element and is arranged to form a seal around the release member when the cartridge is coupled to the dosing device or adaptor.

2. A cartridge according to claim 1 , wherein the coupling element is arranged to define first and second insertion positions for the cartridge with respect to the dosing device or adaptor.

3. A cartridge according to claim 2 , wherein the sealing element is positioned such that, when the cartridge is in the first insertion position, the sealing element prevents release of the medicament from the cartridge and when the cartridge is in the second insertion position, the sealing element cooperates with the release member of the dosing device or adaptor to allow flow of the medicament from the cartridge.

4. A cartridge according to claim 3 , wherein the coupling element comprises first and second engagement formations for cooperation with the dosing device or the adaptor thereby to define the first and second insertion positions.

5. A cartridge according to claim 2 , wherein the seal arrangement is arranged to form a seal around the release member when the cartridge is in the first insertion position.

6. A cartridge according to claim 2 , wherein the coupling element comprises an engagement formation for cooperation with the engagement part of the dosing device or adaptor upon insertion of the cartridge.

7. A cartridge according to claim 6 , wherein the or at least one of the engagement formations comprises a ramp formation for cooperation with the engagement part of the dosing device or adaptor, the ramp formation being configured to engage with the engagement part of the dosing device or adaptor upon insertion of the cartridge.

8. A cartridge according to claim 6 , wherein the or at least one of the engagement formations comprises a recess for engagement with a corresponding projection of the dosing device or adaptor.

9. A cartridge according to claim 1 , wherein the seal arrangement provides an enclosed chamber adjacent the sealing element for receiving a proximal tip of the release member when the seal is formed around the release member.

10. A cartridge according to claim 1 , wherein the sealing element closes the passage.

11. A cartridge according to claim 1 , wherein the sealing surface is defined by a narrowed region of the passage that is narrower than a remainder of the passage.

12. A cartridge according to claim 1 , wherein the closure member comprises the seal arrangement.

13. A cartridge according to claim 12 , wherein the closure member is elastically deformable to receive the release member and to form the seal around the release member.

14. A cartridge according to claim 1 , wherein the coupling element comprises the seal arrangement.

15. A cartridge according to claim 14 , wherein the seal arrangement comprises a tubular portion for receiving the release member.

16. A cartridge according to claim 15 , wherein a proximal end of the tubular portion is arranged to clamp the closure member to the body.

17. A cartridge according to claim 14 , wherein the closure member is an elastomeric disc.

18. A cartridge according to claim 1 , wherein the closure member comprises an elastomeric bung which is at least partially received in the distal end of the cavity of the body.

19. A cartridge according to claim 1 , wherein the distal end of the body comprises an annular collar, and wherein the coupling element includes a clip formation to engage with the collar, thereby to secure the coupling element to the body.

20. A cartridge according to claim 19 , wherein the coupling element is arranged to apply a clamping force to the closure member when the clip formation is engaged with the collar, thereby to retain the closure member against the body.

21. A cartridge according to claim 19 , comprising a retainer for applying a retaining force to the clip formation to maintain engagement between the clip formation and the collar.

22. A cartridge according to claim 1 , wherein the sealing element comprises a pierceable septum.

23. A cartridge connector for a dosing device or adaptor for use with the cartridge of claim 1 , comprising the engagement part for engagement with the coupling element of the cartridge to clip the cartridge to the dosing device or adaptor upon insertion of the cartridge to the cartridge connector.

24. A cartridge connector according to claim 23 , wherein the engagement part is configured to engage with an engagement formation of the coupling element.

25. A cartridge connector according to claim 24 , wherein the engagement part comprises a ramp formation for cooperation with the engagement formation of the coupling element of the cartridge.

26. A cartridge connector according to claim 25 , wherein the ramp formation comprises a ramped proximal side to allow the engagement formation on the coupling element of the cartridge to pass the ramp formation upon insertion of the cartridge.

27. A dosing device comprising the cartridge connector according to claim 23 and a sealing element release member arranged to cooperate with the sealing element of the closure member upon insertion of the cartridge to allow release of medicament from the cartridge.

28. A dosing device according to claim 27 , further comprising a cannula, wherein the release member comprises a tube member in fluid connection with the cannula.

29. A dosing device according to claim 28 , wherein the tube member extends from an enlarged diameter part of the release member, and wherein the seal arrangement is arranged to form a seal with the enlarged diameter part of the release member.

30. A dosing device according to claim 28 , wherein the cannula is non-axially aligned with respect to the release member.

31. A dosing device according to claim 27 , further comprising a needle, wherein the release member comprises a proximal end of the needle.

32. An adaptor for use with the cartridge according to claim 1 , the adaptor comprising:
the engagement part;
an adaptor body housing a medicament chamber;
an adaptor seal for sealing a distal end of the chamber; and
wherein the sealing element release member is arranged to cooperate with the sealing element of the cartridge to allow flow of medicament from the

Assignees

• Owen Mumford Ltd

Inventors

• Cowe Toby
• Evans Timothy
• Webb Colin
• Mallon Jake

Classifications

• A61M5/24 Primary

  Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic {(ampoules or carpules A61J1/06)} · CPC title

• A61M2005/2403

  Ampoule inserted into the ampoule holder · CPC title

• A61M2005/2407

  from the rear · CPC title

• A61J1/06

  Ampoules or carpules (syringe ampoules or carpules A61M5/28) · CPC title

• A61M2005/244

  by flexible clip · CPC title