Frame for prosthetic valve

Patent metadata

Field	Value
Publication number	US-11065114-B2
Application number	US-201916374240-A
Country	US
Kind code	B2
Filing date	Apr 3, 2019
Priority date	May 20, 2012
Publication date	Jul 20, 2021
Grant date	Jul 20, 2021

Abstract

Apparatus and methods are described including a valve frame configured to support a prosthetic valve within a native atrio-ventricular valve. The valve frame includes a frame body that includes an atrial portion configured to be positioned such that, when the valve frame is deployed, at least a portion of the atrial portion is disposed on an atrial side of the native atrio-ventricular valve, and a ventricular portion configured to be positioned such that, when the valve frame is deployed, at least a portion of the ventricular portion is disposed within a ventricle of the subject. At least one arm is configured to extend from the ventricular portion of the frame body. Other applications are also described.

First claim

The invention claimed is:

1. A method for use with a prosthetic valve that is configured to be deployed within a native atrio-ventricular valve of a heart of a mammalian subject, the native atrio-ventricular valve including a valve annulus, valve leaflets, chords, and papillary muscles, the method comprising:
placing a valve frame within the subject's heart, the valve frame including:
a valve frame body that is configured to support the prosthetic valve within the native atrio-ventricular valve, and that includes an atrial portion and a ventricular portion, and
at least one arm that is configured to extend from the ventricular portion of the valve frame;

deploying the at least one arm among the chords of the native atrio-ventricular valve;
subsequently, rotating at least a portion of the valve frame, such as to cause the arm to twist the leaflets of the native valve, such that the leaflets of the native valve are placed in overlapping configurations with respect to each other; and
subsequently, causing the frame body of the valve frame to radially expand, such as to trap the leaflets of the native valve in the overlapping configurations with respect to each other.

2. The method according to claim 1 , wherein placing the valve frame within the subject's heart comprises placing two or more parts of the valve frame into the subject's heart and coupling the two or more parts to each other.

3. The method according to claim 1 , wherein rotating at least the portion of the valve frame comprises rotating at least the portion of the valve frame, such as to cause the arm to twist the leaflets of the native valve, such that the leaflets form a seal against each other, such that there is no clinically significant regurgitation from a ventricle of the subject to an atrium of the subject during systole of the subject.

4. The method according to claim 1 , wherein rotating at least the portion of the valve frame comprises rotating at least the portion of the valve frame, such as to cause the arm to twist the leaflets of the native valve, such that at least one commissure between the leaflets of the native atrio-ventricular valve is sealed by the leaflets of the native valve being placed in the overlapping configurations with respect to each other.

5. The method according to claim 1 , wherein deploying the at least one arm among the chords of the native atrio-ventricular valve comprises deploying the at least one arm among the chords of the native atrio-ventricular valve, even when the portion of the valve frame from which the at least one arm extends is in a radially-compressed state.

6. The method according to claim 1 , further comprising preventing chords from exiting the arm, using a protruding member shaped to protrude from the arm.

7. The method according to claim 1 , wherein causing the frame body of the valve frame to radially expand such as to trap the leaflets of the native valve in the overlapping configurations with respect to each other comprises using the at least one arm to trap the native valve leaflets in the overlapping configurations with respect to each other.

8. The method according to claim 1 , wherein causing the frame body of the valve frame to radially expand, such as to trap the leaflets of the native valve in the overlapping configurations with respect to each other comprises trapping the native valve leaflets between the atrial portion of the valve frame and the at least one arm.

9. The method according to claim 1 , wherein the native atrio-ventricular valve includes a native mitral valve, and placing the valve frame within the patient's heart comprises placing within a left heart of the patient a valve frame that is configured to support the prosthetic valve within the native mitral valve.

10. The method according to claim 9 , wherein causing the frame body of the valve frame to radially expand comprises avoiding interfering with left ventricular functioning of the subject by avoiding causing even partial occlusion in a vicinity of an aortic valve of the subject.

11. The method according to claim 9 , wherein causing the frame body of the valve frame to radially expand comprises avoiding interfering with left ventricular functioning of the subject by avoiding causing turbulence in a vicinity of an aortic valve of the subject.

12. A method for use with a prosthetic valve that is configured to be deployed within a native mitral valve of a heart of a mammalian subject, the native mitral valve including a valve annulus, valve leaflets, chords, and papillary muscles, the method comprising:
placing a valve frame within the subject's heart, the valve frame including:
a valve frame body that is configured to support the prosthetic valve within the native mitral valve, and that includes an atrial portion and a ventricular portion, and
at least one arm that is configured to extend from the ventricular portion of the valve frame;

deploying the at least one arm among the chords of the native mitral valve;
subsequently, rotating at least a portion of the valve frame, such as to cause the arm to twist the leaflets of the native mitral valve; and
subsequently, causing the frame body of the valve frame to radially expand, such as to trap the leaflets of the native mitral valve in the twisted configuration, and such as to avoid interfering with left ventricular functioning of the subject by avoiding causing even partial occlusion in a vicinity of an aortic valve of the subject.

13. The method according to claim 12 , wherein causing the frame body of the valve frame to radially expand further comprises avoiding interfering with left ventricular functioning of the subject by avoiding causing turbulence in a vicinity of the subject's aortic valve.

14. The method according to claim 12 , wherein placing the valve frame within the subject's heart comprises placing two or more parts of the valve frame into the subject's heart and coupling the two or more parts to each other.

15. The method according to claim 12 , wherein deploying the at least one arm among the chords of the native mitral valve comprises deploying the at least one arm among the chords of the native mitral valve, even when the portion of the valve frame from which the at least one arm extends is in a radially-compressed state.

16. The method according to claim 12 , further comprising preventing chords from exiting the arm, using a protruding member shaped to protrude from the arm.

17. The method according to claim 12 , wherein causing the frame body of the valve frame to radially expand, such as to trap the leaflets of the native mitral valve in the twisted configuration comprises using the at least one arm to trap the native valve leaflets in the twisted configuration.

18. The method according to claim 12 , wherein causing the frame body of the valve frame to radially expand, such as to trap the leaflets of the native mitral valve in the twisted configuration comprises trapping the native valve leaflets between the atrial portion of the valve frame and the at least one arm.

19. The method according to claim 12 , wherein:
rotating at least the portion of the valve frame comprises twisting the leaflets of the native valve, such that the leaflets of the native mitral valve are shaped into overlapping configurations with respect to each other, and
causing the frame body of the valve frame to radially expand, such as to trap the native valve leaflets in the twisted configuration comprises trapping the leaflets of the native valve in the overlapping configurations with respect to each o

Assignees

• Tel Hashomer Medical Res Infrastructure & Services Ltd

Inventors

• Raanani Ehud
• Orlov Boris
• Harari Boaz
• Meiri Oded
• Rozitsky Lichen

Classifications

• A61F2230/0013

  Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped · CPC title

• A61F2/2418 Primary

  Scaffolds therefor, e.g. support stents · CPC title

• A61F2230/0078

  hyperboloidal · CPC title

• A61F2/2436

  Deployment by retracting a sheath · CPC title

• A61F2220/0016

  with sharp anchoring protrusions, e.g. barbs, pins, spikes · CPC title