Flexible hollow lumen composite

Patent metadata

Field	Value
Publication number	US-11065099-B2
Application number	US-201816153219-A
Country	US
Kind code	B2
Filing date	Oct 5, 2018
Priority date	Oct 6, 2017
Publication date	Jul 20, 2021
Grant date	Jul 20, 2021

Abstract

A composite lumen includes an extruded tube of a composite including a poly(glycerol sebacate) (PGS) matrix mixed with a PGS thermoset filler. The composite lumen also includes an overbraid structure overlying an outer surface of the extruded tube. A method of forming a composite lumen includes extruding a PGS tube of a composite including a PGS matrix mixed with a PGS thermoset filler. The method also includes applying an overbraid structure over an outer surface of the extruded tube.

First claim

What is claimed is:

1. A composite lumen comprising:
an extruded tube of a composite comprising a poly(glycerol sebacate) (PGS) matrix mixed with a PGS thermoset filler; and
an overbraid structure overlying an outer surface of the extruded tube.

2. The composite lumen of claim 1 wherein the PGS thermoset filler comprises a powder of thermoset PGS having an average particle size in the range of about 75 to about 300 microns.

3. The composite lumen of claim 1 , wherein the PGS thermoset filler is present in an amount in the range of 10% to 90% by weight of the extruded tube.

4. The composite lumen of claim 1 , wherein the overbraid structure comprises fibers of a bioresorbable material.

5. The composite lumen of claim 4 , wherein the bioresorbable material is selected from the group consisting of polyglycolide, polylactide, poly(lactic-co-glycolic acid), poly(caprolactone) and PGS.

6. The composite lumen of claim 1 , wherein the overbraid structure is laminated to the extruded tube.

7. The composite lumen of claim 1 , wherein the extruded tube has an inner diameter of less than 6 mm.

8. The composite lumen of claim 1 , wherein the overbraid structure has an overbraid angle in the range of 75° to 151°.

9. The composite lumen of claim 1 , wherein the overbraid structure has a picks per inch in the range of 30 to 150.

10. The composite lumen of claim 1 , wherein the overbraid structure has a 1×1, 2×2, or 2×1 braid pattern.

11. The composite lumen of claim 1 , wherein the overbraid structure has an effective yarn denier in the range of 45 to 90.

12. The composite lumen of claim 1 , wherein the extruded tube has a wall thickness in the range of 200 μm to 1200 μm.

13. A method of forming a composite lumen tube, the method comprising:
extruding a poly(glycerol sebacate) (PGS) tube of a composite comprising a PGS matrix mixed with a PGS thermoset filler; and
applying an overbraid structure over an outer surface of the extruded tube.

14. The method of claim 13 further comprising mixing the PGS matrix with the PGS thermoset filler prior to extruding the PGS tube.

15. The method of claim 13 further comprising heat-setting the overbraid structure after applying the overbraid structure.

16. The method of claim 13 further comprising dip coating the composite lumen tube after applying the overbraid structure to physically connect the overbraid structure with the overbraid structure.

17. The method of claim 13 , wherein the PGS matrix comprises a PGS resin having a weight average molecular weight in the range of 5,000 to 50,000 Da and the PGS thermoset filler comprises a powder of thermoset PGS having an average particle size in the range of about 75 to about 300 microns.

Assignees

• Secant Group Llc

Inventors

• Lu Steven
• Gabriele Peter D
• Harris Jeremy J
• Winner Seth A
• Metzger Andrew

Classifications

• A61L27/48 Primary

  with macromolecular fillers · CPC title

• D04C1/06

  Braid or lace serving particular purposes · CPC title

• A61F2250/0067

  Means for introducing or releasing pharmaceutical products into the body · CPC title

• A61L2430/32

  for nerve reconstruction · CPC title

• A61F2210/0004

  bioabsorbable · CPC title