Techniques for performing optical and electrochemical assays with universal circuitry

Patent metadata

Field	Value
Publication number	US-11060994-B2
Application number	US-201816104204-A
Country	US
Kind code	B2
Filing date	Aug 17, 2018
Priority date	Aug 17, 2017
Publication date	Jul 13, 2021
Grant date	Jul 13, 2021

Abstract

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

First claim

We claim:

1. A system comprising:
one or more processors comprising a universal channel circuitry, wherein the universal channel circuitry comprises a first channel and a second channel, and the first channel comprises first circuitry comprising one or more switches, and the second channel comprises second circuitry comprising one or more switches; and
memory coupled to the one or more processors, the memory encoded with a set of instructions configured to perform a process comprising:
receiving an operating state signal from a test cartridge indicative of a type of test cartridge inserted into an analyzer;
determining, based on the type of test cartridge, that the test cartridge has a first contact connected to a light emitter and a second contact connected to a light detector;
in response to determining the first contact is connected to the light emitter, assigning the first channel to the light emitter via the first contact and a corresponding first pin;
in response to determining the second contact is connected to the light detector, assigning the second channel to the light detector via the second contact and a corresponding second pin;
switching the first circuitry of the first channel to a current driver mode using the one or more switches of the first circuitry;
switching the second circuitry of the second channel to a current measurement mode using the one or more switches of the second circuitry;
applying, using the first channel in the current driver mode, a drive current to the light emitter;
converting, using the second channel in the current measurement mode, an output signal received from the light detector to an analyte signal proportional to an amount of light detected by the light detector; and
determining a qualitative, semi-quantitative, or quantitative value proportional to an amount of analyte in a biological sample in the test cartridge based on the analyte signal.

2. The system of claim 1 , wherein the operating state signal comprises a value of a measured resistance between contacts of the test cartridge and a shorting bar.

3. The system of claim 1 , wherein the operating state signal comprises a value obtained from a barcode located on the test cartridge.

4. The system of claim 1 , wherein the determining that the test cartridge has the first contact connected to the light emitter and the second contact connected to the light detector, comprises: identifying, based on a value of the operating state signal, the type of test cartridge using a look-up table, and obtaining, based on the type of test cartridge, information regarding sensors of the test cartridge from a database, wherein the information indicates that the test cartridge includes an optical sensor that has the light emitter connected to the first contact and the light detector connected to the second contact.

5. The system of claim 1 , wherein the switching the first circuitry of the first channel to a current driver mode, comprises: modifying the one or more switches of the first circuitry such that the first channel is configured to apply the drive current via the first contact and the corresponding first pin to the light emitter.

6. The system of claim 5 , wherein the applying the drive current to the light emitter causes the light emitter to generate output current and light comprising a predetermined wavelength.

7. The system of claim 6 , wherein the process further comprises:
determining, based on the type of test cartridge, that the test cartridge has a third contact connected to the light emitter;
assigning the first channel to the light emitter via the third contact and a corresponding third pin;
receiving, at the first channel, the output current generated by the light emitter from the third contact and the corresponding third pin; and
applying the output current generated by the light emitter to a feedback resistor to establish a constant current for the drive current.

8. The system of claim 7 , wherein the universal channel circuitry further comprises a third channel and a fourth channel, and the third channel comprises third circuitry comprising one or more switches and the fourth channel comprises fourth circuitry comprising one or more switches; and wherein the process further comprises:
determining, based on the type of test cartridge, that the test cartridge has one of the first contact, the second contact, the third contact, or a fourth contact connected to a first conductometric electrode, and one of the first contact, the second contact, the third contact, or the fourth contact connected to a second conductometric electrode;
in response to determining one of the first contact, the second contact, the third contact, or the fourth contact is connected to the first conductometric electrode, assigning the third channel to the first conductometric electrode via the first contact, the second contact, the third contact, or the fourth contact and the corresponding first pin, the second pin, the third pin, or a fourth pin;
in response to determining one of the first contact, the second contact, the third contact, or the fourth contact is connected to the second conductometric electrode, assigning the fourth channel to the second conductometric electrode via the first contact, the second contact, the third contact, or the fourth contact and the corresponding first pin, the second pin, the third pin, or the fourth pin;
switching the third circuitry of the third channel to a high conductometric mode using the one or more switches of the third circuitry;
switching the fourth circuitry of the fourth channel to a low conductometric mode using the one or more switches of the fourth circuitry;
applying, using the third channel in the high conductometric mode, a potential to the first conductometric electrode;
measuring, using the third channel in the high conductometric mode and the fourth channel in the low conductometric mode, a voltage change across the biological sample that is proportional to conductivity of the biological sample; and
determining a position of the biological sample within the test cartridge based on the voltage change across the biological sample.

9. The system of claim 8 , wherein the process further comprises determining a hematocrit level of the biological sample by comparing the voltage change to known values of hematocrit on a calibration curve and converting the voltage change to a rating for the hematocrit level.

10. The system of claim 1 , wherein the universal channel circuitry further comprises a third channel and a fourth channel, and the third channel comprises third circuitry comprising one or more switches and the fourth channel comprises fourth circuitry comprising one or more switches; and wherein the process further comprises:
determining, based on the type of test cartridge, that the test cartridge has a third contact connected to a counter electrode, a fourth contact connected to a reference electrode, and the second contact connected to an amperometric electrode;
in response to determining the third contact is connected to the counter electrode, assigning the third channel to the counter electrode via the third contact and a corresponding third pin;
in response to determining the fourth contact is connected to the reference electrode, assigning the fourth channel to the reference electrode via the fourth contact and a corresponding fourth pin;
in response to determining the second contact is connected to the amperometric electrode, assigning the second channel to the amperometric electrode via the second contact and the corresponding second pin;
switching the third circuitry of the third channel to a counter electrode measurement mode using the one or more switc

Assignees

• Abbott Point Of Care Inc

Inventors

• Low Michael Louie
• Bass Barry
• Gershtein Sergey

Classifications

• B01L3/502753 Primary

  characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation · CPC title

• G01N27/4161

  measuring the voltage and using a constant current supply, e.g. chronopotentiometry · CPC title

• G01N27/07

  Construction of measuring vessels; Electrodes therefor · CPC title

• G01N27/27

  Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter · CPC title

• G01N27/3273

  Devices therefor, e.g. test element readers, circuitry (details not specific to biochemical electrodes G01N33/4875) · CPC title