Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors
US-9873740-B2 · Jan 23, 2018 · US
US11059888B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11059888-B2 |
| Application number | US-201716095024-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 19, 2017 |
| Priority date | Apr 20, 2016 |
| Publication date | Jul 13, 2021 |
| Grant date | Jul 13, 2021 |
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A regulatory T cell activator including a substance that inhibits the binding between DNAX accessory molecule-1 (DNAM-1) and CD155.
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The invention claimed is: 1. An anti-human DNAM-1 monoclonal antibody or a fragment thereof, comprising a heavy-chain variable region having the amino acid sequence of SEQ ID NO: 7 and a light-chain variable region having the amino acid sequence of SEQ ID NO: 8. 2. The anti-human DNAM-1 monoclonal antibody or a fragment thereof according to claim 1 , the antibody or a fragment thereof being a humanized antibody or a fragment of a humanized type antibody.
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Cells modified by introduction of foreign genetic material · CPC title
Antagonist effect on antigen, e.g. neutralization or inhibition of binding · CPC title
Complementarity determining region [CDR] · CPC title
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