Biodegradable magnesium alloys, methods of manufacture thereof and articles comprising the same

Patent metadata

Field	Value
Publication number	US-11053572-B2
Application number	US-201916277173-A
Country	US
Kind code	B2
Filing date	Feb 15, 2019
Priority date	Jul 3, 2013
Publication date	Jul 6, 2021
Grant date	Jul 6, 2021

Abstract

Disclosed herein is an article comprising a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.

First claim

What is claimed is:

1. A method comprising:
blending three or more metals to form a metal alloy, where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof;
molding the metal alloy; and
annealing the metal alloy at a temperature and in an atmosphere effective to produce a protective layer on the metal alloy; where the protective layer is reactively bonded to the metal alloy and where the protective layer is non-metallic, where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.

2. The method of claim 1 , where the metal alloy is annealed at a temperature of about 25 to about 800° C.

3. The method of claim 1 , where the atmosphere contains oxygen, carbon, boron, silicon, selenium, fluorine, bromine, iodine, tellurium, sulfur, nitrogen, or a combination thereof.

4. The method of claim 1 , where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and
where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.

5. The method of claim 4 , where the protective layer comprises a plurality of layers; with an outermost layer comprising an oxide of magnesium, calcium, strontium, or a combination thereof; while an inner layer comprises an oxide of scandium, gadolium, cerium, neodymium, dysporium, or a combination thereof.

6. The method of claim 4 , where the protective layer has a thickness of 0.1 nanometers to 500 nanometers.

7. The method of claim 4 , wherein the base metal is magnesium.

8. The method of claim 4 , wherein the base metal is calcium.

9. The method of claim 4 , wherein the base metal is strontium.

10. The method of claim 4 , wherein the base metal is zinc.

11. The method of claim 4 , wherein the base metal is magnesium, the second element is scandium, and the third element is cerium.

12. The method of claim 1 , where the metal alloy comprises a base metal, a second element and a third element; where the base metal is calcium, strontium, zinc, or a combination thereof where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and
where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.

13. The method of claim 12 , where the protective layer comprises a plurality of layers; with an outermost layer comprising an oxide of calcium, strontium, or a combination thereof; while an inner layer comprises an oxide of scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof.

14. The method of claim 12 , wherein the second element is yttrium and the third element is scandium.

15. The method of claim 12 , wherein the second element is yttrium and the third element is selected from gadolium, cerium, neodymium, dysporium, or a combination thereof.

16. The method of claim 12 , wherein the second element is scandium and the third element is selected from gadolium, cerium, neodymium, dysporium, or a combination thereof.

17. The method of claim 1 , where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof where the second element is chemically different from the third element; and where the second element and the third element are gadolium, cerium, neodymium, dysporium, or a combination thereof;
where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another; and
wherein the protective layer comprises a plurality of layers; with an outermost layer comprising an oxide of magnesium, calcium, strontium, or a combination thereof while an inner layer comprises an oxide of gadolium, cerium, neodymium, dysporium, or a combination thereof.

18. The method of claim 17 , wherein the outermost layer is an oxide of magnesium.

19. The method of claim 17 , wherein the outermost layer is an oxide of calcium.

20. The method of claim 17 , wherein the outermost layer is an oxide of strontium or an oxide of zinc.

Assignees

• Univ Florida

Inventors

• Manuel Michele
• Allen Josephine
• Ball Jordan P
• Brar Harpreet Singh
• Berglund Ida Svensson

Classifications

• C22C1/0408

  Light metal alloys · CPC title

• C22C23/00 Primary

  Alloys based on magnesium · CPC title

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title

• A61L27/306

  Other specific inorganic materials not covered by A61L27/303 - A61L27/32 · CPC title

• A61L27/047

  Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06 · CPC title