Transcranial intervention to weaken an undesirable memory

Patent metadata

Field	Value
Publication number	US-11052252-B1
Application number	US-201916418920-A
Country	US
Kind code	B1
Filing date	May 21, 2019
Priority date	Jun 7, 2017
Publication date	Jul 6, 2021
Grant date	Jul 6, 2021

Abstract

Described is a system for weakening an undesirable memory. The system initiates application of a first pattern of spatiotemporally distributed transcranial stimulation via a set of electrodes to a subject who is in a calm mental state, causing association of the first pattern of spatiotemporally distributed transcranial stimulation with the calm mental state. The system then initiates application of the first pattern of spatiotemporally distributed transcranial stimulation via the set of electrodes when the undesirable memory is recalled by the subject, causing recall of the calm mental state and reconsolidation of the undesirable memory with the calm mental state.

First claim

What is claimed is:

1. A system for weakening an undesirable memory during wake periods, the system comprising:
one or more processors and a non-transitory memory having instructions encoded thereon such that when the instructions are executed, the one or more processors perform operations of:
during a wake period of a subject, initiating application of a first pattern of spatiotemporally distributed transcranial stimulation via a set of electrodes to the subject who is in a calm mental state, thereby causing association of the first pattern of spatiotemporally distributed transcranial stimulation with the calm mental state; and
initiating application of the first pattern of spatiotemporally distributed transcranial stimulation via the set of electrodes when the undesirable memory is recalled by the subject, thereby causing recall of the calm mental state and reconsolidation of the undesirable memory with the calm mental state.

2. The system as set forth in claim 1 , wherein the transcranial stimulation is one of weak high-definition transcranial alternating current stimulation, weak high-definition transcranial direct current stimulation, and transcranial magnetic stimulation.

3. The system as set forth in claim 1 , wherein the one or more processors further perform operations of:
stopping the application of the first pattern of spatiotemporally distributed transcranial stimulation following detection of a non-calm state in the subject during application of the first pattern of spatiotemporally distributed transcranial stimulation; and
initiating application of a second pattern of spatiotemporally distributed transcranial stimulation via the set of electrodes to the subject when in the calm mental state, causing association of the second pattern of spatiotemporally distributed transcranial stimulation with the calm mental state.

4. The system as set forth in claim 1 , wherein the one or more processors further perform operations of:
assigning a stress metric value based on a measured level of stress in the subject; and
causing a perceptible change in a mobile device as an alert when the stress metric value exceeds a threshold.

5. The system as set forth in claim 4 , wherein the first pattern of spatiotemporally distributed transcranial stimulation is applied when the stress metric value is below the threshold.

6. The system as set forth in claim 4 , wherein when the stress metric value exceeds the threshold, stopping application of the first pattern of spatiotemporally distributed transcranial stimulation.

7. A computer implemented method for weakening an undesirable memory during wake periods, the method comprising acts of:
causing one or more processers to execute instructions encoded on a non-transitory computer-readable medium, such that upon execution, the one or more processors perform operations of:
during a wake period of a subject, initiating application of a first pattern of spatiotemporally distributed transcranial stimulation via a set of electrodes to the subject who is in a calm mental state, thereby causing association of the first pattern of spatiotemporally distributed transcranial stimulation with the calm mental state; and
initiating application of the first pattern of spatiotemporally distributed transcranial stimulation via the set of electrodes when the undesirable memory is recalled by the subject, thereby causing recall of the calm mental state and reconsolidation of the undesirable memory with the calm mental state.

8. The method as set forth in claim 7 , wherein the transcranial stimulation is one of weak high-definition transcranial alternating current stimulation, weak high-definition transcranial direct current stimulation, and transcranial magnetic stimulation.

9. The method as set forth in claim 7 , wherein the one or more processors further perform operations of:
stopping the application of the first pattern of spatiotemporally distributed transcranial stimulation following detection of a non-calm state in the subject during application of the first pattern of spatiotemporally distributed transcranial stimulation; and
initiating application of a second pattern of spatiotemporally distributed transcranial stimulation via the set of electrodes to the subject when in the calm mental state, causing association of the second pattern of spatiotemporally distributed transcranial stimulation with the calm mental state.

10. The method as set forth in claim 7 , wherein the one or more processors further perform operations of:
assigning a stress metric value based on a measured level of stress in the subject; and
causing a perceptible change in a mobile device as an alert when the stress metric value exceeds a threshold.

11. The method as set forth in claim 10 , wherein the first pattern of spatiotemporally distributed transcranial stimulation is applied when the stress metric value is below the threshold.

12. The method as set forth in claim 10 , wherein when the stress metric value exceeds the threshold, stopping application of the first pattern of spatiotemporally distributed transcranial stimulation.

13. A computer program product for weakening an undesirable memory during wake periods, the computer program product comprising:
computer-readable instructions stored on a non-transitory computer-readable medium that are executable by a computer having one or more processors for causing the processor to perform operations of:
during a wake period of a subject, initiating application of a first pattern of spatiotemporally distributed transcranial stimulation via a set of electrodes to the subject who is in a calm mental state, thereby causing association of the first pattern of spatiotemporally distributed transcranial stimulation with the calm mental state; and

initiating application of the first pattern of spatiotemporally distributed transcranial stimulation via the set of electrodes when the undesirable memory is recalled by the subject, thereby causing recall of the calm mental state and reconsolidation of the undesirable memory with the calm mental state.

14. The computer program product as set forth in claim 13 , wherein the transcranial stimulation is one of weak high-definition transcranial alternating current stimulation, weak high-definition transcranial direct current stimulation, and transcranial magnetic stimulation.

15. The computer program product as set forth in claim 13 , wherein the one or more processors further perform operations of:
stopping the application of the first pattern of spatiotemporally distributed transcranial stimulation following detection of a non-calm state in the subject during application of the first pattern of spatiotemporally distributed transcranial stimulation; and
initiating application of a second pattern of spatiotemporally distributed transcranial stimulation via the set of electrodes to the subject when in the calm mental state, causing association of the second pattern of spatiotemporally distributed transcranial stimulation with the calm mental state.

16. The computer program product as set forth in claim 13 , wherein the one or more processors further perform operations of:
assigning a stress metric value based on a measured level of stress in the subject; and
causing a perceptible change in a mobile device as an alert when the stress metric value exceeds a threshold.

17. The computer program product as set forth in claim 16 , wherein the first pattern of spatiotemporally distributed transcranial stimulation is applied when the stress metric value is below the threshold.

Assignees

• Hrl Lab Llc

Inventors

• Howard Michael D
• Pilly Praveen K

Classifications

• A61B5/6803

  Head-worn items, e.g. helmets, masks, headphones or goggles · CPC title

• A61N2/006

  for magnetic stimulation of nerve tissue · CPC title

• A61N1/36025 Primary

  for treating a mental or cerebral condition · CPC title

• A61N1/20

  continuous direct currents · CPC title

• A61N1/0456

  Specially adapted for transcutaneous electrical nerve stimulation [TENS] · CPC title