Compositions for weight loss

Patent metadata

Field	Value
Publication number	US-11052125-B2
Application number	US-201916396902-A
Country	US
Kind code	B2
Filing date	Apr 29, 2019
Priority date	Apr 30, 2018
Publication date	Jul 6, 2021
Grant date	Jul 6, 2021

Abstract

The present invention discloses a composition comprising extracts of Cyperus rotundus, standardized to contain 3-5% w/w total stilbenes, extracts of Garcinia sp., standardized to contain 20% w/w garcinol and extracts of Coleus forskohlii standardized to contain not less than 10% w/w forskolin for the therapeutic management of diet induced obesity and weight gain and related conditions like liver dysfunction, NASH, NAFLD, liver cirrhosis, hypercholesterolemia, hyperlipidemia, kidney dysfunction by bringing about a reduction in body weight, increasing lean body mass and by normalizing the levels of liver enzymes, kidney markers and circulating lipids.

First claim

We claim:

1. A method for therapeutic management of kidney dysfunction in mammals in need thereof, said method comprising step of administering a composition consisting essentially of extracts of Cyperus rotundus , standardized to contain 3-5% w/w total stilbenes, extracts of Garcinia sp., standardized to contain 20% w/w garcinol, extracts of Coleus forskohlii standardized to contain not less than 10% w/w forskolin and 10% phospholipids in effective doses to said mammals to bring about a reduction in the elevated levels of markers of kidney damage.

2. The method as in claim 1 , wherein the effective doses of the total stilbenes, forskolin and garcinol are 50 mg/day, 25 mg/day and 10 mg/day respectively.

3. The method as in claim 1 , wherein the stilbenes of Cyperus rotundus extracts consists of picetannol, scirpusin A and scirpusin B.

4. The method as in claim 1 , wherein the Garnicia sp. include Garcinia cambogia and Garcinia indica.

5. The method as in claim 1 , wherein the kidney dysfunction is induced by high fat diet.

6. The method as in claim 1 , wherein the markers of kidney dysfunction is selected from the group consisting of creatinine, uric acid, blood urea nitrogen, and total protein.

7. The method as in claim 1 , wherein the mammal is human.

8. The method as in claim 1 , wherein the composition is formulated with pharmaceutically/nutraceutically accepted excipients, preservatives, bioavailability enhancers, antioxidants, and adjuvants and administered orally in the form of tablets, capsules, syrups, gummies, chewing gum, powders, suspensions, emulsions, chewables, candies, lozenges or eatables.

Assignees

• Majeed Muhammed
• Nagabhushanam Kalyanam
• Mundkur Lakshmi
• Bani Sarang
• Pandey Anjali
• Sami Labs Ltd

Inventors

• Majeed Muhammed
• Nagabhushanam Kalyanam
• Mundkur Lakshmi
• Bani Sarang
• Pandey Anjali

Classifications

• A61K36/38

  Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort · CPC title

• A61K36/53

  Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender · CPC title

• A61K36/8905 Primary

  Cyperus (flatsedge) · CPC title

• A61K36/67

  Piperaceae (Pepper family), e.g. Jamaican pepper or kava · CPC title

• A61P3/04 Primary

  Anorexiants; Antiobesity agents · CPC title