Coating composition, drug-containing particle, solid preparation and method for preparing drug-containing particle

Patent metadata

Field	Value
Publication number	US-11052051-B2
Application number	US-201414151205-A
Country	US
Kind code	B2
Filing date	Jan 9, 2014
Priority date	Jan 11, 2013
Publication date	Jul 6, 2021
Grant date	Jul 6, 2021

Abstract

Provided are a drug-containing particle capable of suppressing dissolution of a drug in the oral cavity to suppress an unpleasant taste thereof and having excellent dissolution of the drug in the digestive tract after passing through the oral cavity; a method for preparing the drug-containing particle; a coating composition used for preparing the drug-containing particle; and a solid preparation having the drug-containing particle. More specifically, provided are a coating composition having 100 parts by weight of a cellulose-based enteric base and 50 parts by weight or less of a water-soluble cellulose ether; a drug-containing particle having a drug-containing core and a coat portion obtained by coating the core with the coating composition; a solid preparation having the drug-containing particle; and a method for preparing a drug-containing particle having a step of coating the drug-containing core with the coating composition.

First claim

The invention claimed is:

1. A coating composition comprising: 100 parts by weight of a cellulose-based enteric base and 10 to 45 parts by weight of a water-soluble cellulose ether, and 0 parts by weight of a water-insoluble cellulose ether excluding the cellulose-based enteric base, wherein the cellulose-based enteric base is hydroxypropylmethyl cellulose acetate succinate or hydroxypropylmethyl cellulose phthalate, and the water-soluble cellulose ether is methyl cellulose or hydroxypropylmethyl cellulose.

2. The coating composition according to claim 1 , wherein the cellulose-based enteric base is hydroxypropylmethyl cellulose acetate succinate.

3. A drug-containing particle comprising:
a drug-containing core and
a coat portion on the drug-containing core obtained by coating the drug-containing core with the coating composition as claimed in claim 1 .

4. The drug-containing particle according to claim 3 , wherein the drug-containing particle has an average particle size of 300 μm or less.

5. A solid preparation comprising the drug-containing particle as claimed in claim 3 .

6. The solid preparation according to claim 5 , wherein the solid preparation is an orally disintegrating tablet.

7. A method for preparing a drug-containing particle, comprising a step of coating a drug-containing core with the coating composition as claimed in claim 1 .

8. The method for preparing a drug-containing particle according to claim 7 , wherein the step of coating comprises application of a solution obtained by dissolving the coating composition in a solvent to the drug-containing core.

9. The method for preparing a drug-containing particle according to claim 8 , wherein the solvent is an aqueous solution of ammonia.

Assignees

• Shinetsu Chemical Co

Inventors

• Yokosawa Takuya
• Nishiyama Yuichi
• Maruyama Naosuke

Classifications

• A61K9/5047 Primary

  Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose · CPC title

• A61K9/5078

  with drug-free core · CPC title

• C09D101/32

  Cellulose ether-esters · CPC title

• A61K9/5042

  Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose · CPC title

• A61K9/2081

  with microcapsules or coated microparticles according to A61K9/50 · CPC title