Membrane for immunoisolation, chamber for transplantation, and device for transplantation

Patent metadata

Field	Value
Publication number	US-11051930-B2
Application number	US-201916409241-A
Country	US
Kind code	B2
Filing date	May 10, 2019
Priority date	Nov 11, 2016
Publication date	Jul 6, 2021
Grant date	Jul 6, 2021

Abstract

According to the present invention, there are provided a membrane for immunoisolation, including: a porous membrane that contains a polymer, in which the porous membrane includes a layered compact portion where a pore diameter is the smallest within the membrane, and a pore diameter continuously increases in a thickness direction from the compact portion toward at least one surface of the porous membrane; a chamber for transplantation for enclosing a biological constituent therein, including the above-described membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation; and a device for transplantation, including the above-described chamber for transplantation enclosing the biological constituent therein. In the membrane for immunoisolation of the present invention which can be manufactured at low costs, a deterioration in substance permeability is unlikely to occur.

First claim

What is claimed is:

1. A membrane for immunoisolation, comprising:
a porous membrane that contains a polymer,
wherein the porous membrane includes a layered compact portion where a pore diameter is smallest within the membrane, and
a pore diameter continuously increases in a thickness direction from the compact portion toward at least one surface of the porous membrane,
wherein the porous membrane has a minimum pore diameter of 0.2 μm to 1.5 μm.

2. The membrane for immunoisolation according to claim 1 , which is made from the porous membrane.

3. The membrane for immunoisolation according to claim 1 , wherein the porous membrane has a minimum pore diameter of 0.2 μm to 1.3 μm.

4. The membrane for immunoisolation according to claim 1 , wherein a ratio of a minimum pore diameter to a maximum pore diameter of the porous membrane is 3.0 to 20.0.

5. The membrane for immunoisolation according to claim 1 , wherein the compact portion has a thickness of 0.5 μm to 30 μm.

6. The membrane for immunoisolation according to claim 1 , wherein the porous membrane has a thickness of 10 μm to 250 μm.

7. The membrane for immunoisolation according to claim 1 , wherein the porous membrane contains at least one kind of polysulfone and polyvinylpyrrolidone.

8. The membrane for immunoisolation according to claim 1 , wherein the compact portion is located between any one surface X of the porous membrane and a portion at a distance of two-fifths the thickness of the porous membrane from the surface X,
wherein the surface X is the surface of the porous membrane closer to the compact portion.

9. The membrane for immunoisolation according to claim 1 , wherein the compact portion is located between any one surface X of the porous membrane and a portion at a distance of one-third the thickness of the porous membrane from the surface X.

10. The membrane for immunoisolation according to claim 9 , wherein a pore diameter continuously increases in the thickness direction from the compact portion toward at least a surface opposite to the surface X of the porous membrane.

11. The membrane for immunoisolation according to claim 10 , wherein a pore diameter continuously increases in the thickness direction from the compact portion toward both surfaces of the porous membrane.

12. The membrane for immunoisolation according to claim 1 , wherein the porous membrane comprises at least one kind of polysulfone, polyvinylpyrrolidone, and lithium chloride.

13. A chamber for transplantation for enclosing a biological constituent therein, the chamber comprising:
a membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation,
wherein the membrane for immunoisolation comprises:
a porous membrane that contains a polymer,
wherein the porous membrane includes a layered compact portion where a pore diameter is smallest within the membrane, and
a pore diameter continuously increases in a thickness direction from the compact portion toward at least one surface of the porous membrane.

14. The chamber for transplantation according to claim 13 ,
wherein the compact portion is located between any one surface X of the porous membrane and a portion at a distance of two-fifths the thickness of the porous membrane from the surface X,
wherein the surface X is the surface of the porous membrane closer to the compact portion, and
wherein the surface X of the porous membrane is on the inside.

15. The chamber for transplantation according to claim 13 , wherein the biological constituent is a cell.

16. A device for transplantation, comprising the chamber for transplantation according to claim 13 enclosing the biological constituent therein.

17. The device for transplantation according to claim 16 , wherein the biological constituent releases a physiologically active substance.

18. The device for transplantation according to claim 17 , wherein the physiologically active substance is insulin.

19. A method of transplantation of the biological constituent, comprising transplanting the device for transplantation according to claim 16 into a recipient.

20. A method of transplantation of insulin-secreting cells, comprising transplanting the device for transplantation according to claim 18 into a recipient.

Assignees

• Fujifilm Corp

Inventors

• Mochizuki Yusuke
• Nakamura Kentaro
• Ohtani Shigeaki
• Matsunaga Naohiro
• Takegami Ryuta

Classifications

• A61F2/02

  Prostheses implantable into the body · CPC title

• A61L31/04

  Macromolecular materials · CPC title

• A61K35/12

  Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells (vaccines or medicinal preparations containing antigens or antibodies A61K39/00) · CPC title

• A61K2035/128

  capsules, e.g. microcapsules · CPC title

• A61L27/16

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title