System and method for non-invasive monitoring of advanced glycation end-products (AGE)

Patent metadata

Field	Value
Publication number	US-11051727-B2
Application number	US-201815866160-A
Country	US
Kind code	B2
Filing date	Jan 9, 2018
Priority date	Jan 9, 2018
Publication date	Jul 6, 2021
Grant date	Jul 6, 2021

Abstract

A method of non-invasively monitoring advanced glycation end-product (AGE) concentrations includes providing incident light to patient tissue at one or more excitation wavelengths and monitoring the one or more emission responses at one or more emission wavelengths. Based on the emission responses monitored, a ratio is calculated based on a ratio of the first emission response to the second emission response.

First claim

The invention claimed is:

1. A system for non-invasive monitoring of advanced glycation end-products (AGEs), the system comprising:
a medical device comprising:
a first light emitter configured to provide a first excitation signal to patient tissue at a first excitation wavelength;
a second light emitter configured to provide a second excitation signal to patient tissue at a second excitation wavelength;
at least one photodetector configured to monitor an emission response at a first emission wavelength, wherein the first emission wavelength is selected to correspond with a maximum of the emission response to either the first excitation signal or the second excitation signal; and

one or more processors configured to:
receive emission responses measured at the first emission wavelength in response to the first and the second excitation wavelengths;
monitor an autofluorescence decay of a first emission response to the light provided at the first excitation wavelength, wherein monitoring the autofluorescence decay of the first emission response comprises measuring a rate of decay for the first emission response;
monitor an autofluorescence decay of a second emission response to the light provided at the second excitation wavelength, wherein monitoring the autofluorescence decay of the second emission response comprises measuring a rate of decay for the second emission response;
calculate a ratio of the rate of decay of the first emission response to the rate of decay of the second emission response; and
determine an AGE concentration level based on the ratio.

2. The system of claim 1 , wherein the one or more processors generate an alert in response to the AGE concentration level exceeding or falling below a threshold value.

3. The system of claim 1 , wherein the AGE concentration level is determined in real-time or near real-time by the one or more processors.

4. The system of claim 1 , wherein the first excitation wavelength is selected to generate an emission response having a maximum responsive to the AGE, and wherein the second excitation wavelength is selected to generate an emission response having a minimum response to AGE concentrations, wherein the ratio provides an assessment of AGE concentration.

5. The system of claim 4 , wherein the first and second light emitters are configured to provide the first excitation signal and second excitation signal to patient tissue mutually exclusive of one another.

6. The system of claim 1 , wherein the at least one photodetector is configured to measure an amplitude/intensity of the monitored emission response.

7. The system of claim 1 , wherein the one or more processors are included as part of the medical device.

8. The system of claim 1 , wherein the one or more processors are configured to calculate an initial AGE concentration and generate alarm/warning thresholds based on the calculated initial AGE concentration.

9. The system of claim 8 , wherein the one or more processors are configured to compare measured AGE concentrations with the generated alarm/warning thresholds to detect a patient condition.

10. The system of claim 1 , wherein the AGE is glycated hemoglobin (HbA1c).

11. A method of non-invasively monitoring advanced glycation end-products (AGEs) concentration, the method comprising:
providing incident light to patient tissue at a first excitation wavelength;
monitoring an autofluorescence decay of a first emission response to the light provided at the first excitation wavelength, wherein monitoring the autofluorescence decay of the first emission response comprises measuring a rate of decay for the first emission response;
providing incident light to patient tissue at a second excitation wavelength;
monitoring an autofluorescence decay of a second emission response to the light provided at the second excitation wavelength, wherein monitoring the autofluorescence decay of the second emission response comprises measuring a rate of decay for the second emission response; and
calculating an AGE concentration based on a ratio of the rate of decay of the first emission response to the rate of decay of the second emission response.

12. The method of claim 11 , wherein the AGE is glycated hemoglobin (HbA1c) and the method further includes assessing a risk of diabetes based on the calculated HbA1c concentration.

13. The method of claim 11 , wherein monitoring the autofluorescence decay of the first emission response and the autofluorescence decay of the second emission response and calculating the AGE concentration is performed in real-time or near real-time.

14. The method of claim 11 , wherein the first excitation wavelength is selected to generate an emission response having a maximum responsive to AGE concentrations, and wherein the second excitation wavelength is selected to generate an emission response having a minimum responsive to AGE concentrations, wherein the ratio provides an assessment of AGE concentration.

Assignees

• Medtronic Monitoring Inc

Inventors

• Katra Rodolphe

Classifications

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/0071

  by measuring fluorescence emission · CPC title

• A61B5/1455 Primary

  using optical sensors, e.g. spectral photometrical oximeters · CPC title

• G01N27/3271

  Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood (amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001) · CPC title