Small molecule antimicrobials

Patent metadata

Field	Value
Publication number	US-11046668-B2
Application number	US-201716083811-A
Country	US
Kind code	B2
Filing date	Mar 6, 2017
Priority date	Mar 11, 2016
Publication date	Jun 29, 2021
Grant date	Jun 29, 2021

Abstract

Compounds and compositions of matter are provided that are small molecule antimicrobials. The compounds are selected from JH-144, TH-04 or TH-08 or combinations thereof. Compositions of matter are provided which in an embodiment may comprise a carrier, and in further embodiments may comprise a pharmaceutically acceptable excipient, film, biofilm or edible film. Methods of use are provided in which the composition may be administered to a subject in need thereof, and in an embodiment where the subject has a bacterial infection. Other embodiments provide the composition may be contacted with surface to eliminate or reduce bacteria.

First claim

What is claimed is:

1. A composition of matter comprising an antimicrobial compound, said composition comprising a compound selected from JA-144, TH-04 or TH-08 or combination thereof, said compound having the following formula:

or pharmaceutically acceptable salts thereof.

2. The composition of matter of claim 1 further comprising a carrier.

3. The composition of matter of claim 2 , wherein said carrier comprises a pharmaceutically acceptable excipient.

4. The composition of matter of claim 3 , comprising a composition for topical administration.

5. The composition of matter of claim 3 , comprising a composition for systemic administration.

6. The composition of matter of claim 2 , wherein said carrier comprises a film.

7. The composition of matter of claim 6 , wherein said compound is JA-144.

8. The composition of matter of claim 6 , wherein said film comprises an edible film.

9. The composition of matter of claim 8 , wherein said compound is JA-144.

10. The composition of matter of claim 6 , wherein said film comprises a package.

11. The composition of matter of claim 10 , wherein said compound is TH-4 or TH-8 or combination thereof.

12. A method of treating a subject in need of treatment for a bacterial infection, said method comprising administering to said subject an effective amount of a composition comprising a compound of JA-144, TH-04 or TH-08 or combination thereof, having the following formula:

or pharmaceutically acceptable salts thereof.

13. The method of claim 12 , said composition further comprising a carrier.

14. The method of claim 12 , wherein said carrier comprises a pharmaceutically acceptable excipient.

15. The method of claim 12 , wherein said subject is a mammal.

16. The method of claim 12 , wherein said subject is poultry and said bacterial infection comprises a Campylobacteria infection.

17. A method of inhibiting bacterial growth on a surface, the method comprising contacting said surface with a composition of matter comprising an effective amount of a compound of JA-144, TH-04 or TH-08 or combination thereof, having the following formula:

or pharmaceutically acceptable salts thereof.

18. The method of claim 17 , wherein said compositions comprises a carrier.

19. The method of claim 18 , wherein said carrier comprises a film.

20. The method of claim 18 , wherein said carrier comprises an edible film.

Assignees

• Ohio State Innovation Foundation

Inventors

• Rajashekara Gireesh
• Acuna Ulyana Munoz
• Antwi Janet
• De Blanco Esperanza Carcache
• Fuchs James
• Kumar Anand
• Nislow Corey
• Pascall Melvin
• Wan Zilu

Classifications

• A61K31/4439 Primary

  containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465) · CPC title

• A61K9/70

  Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres A61K9/0092)} · CPC title

• C07D333/34

  Sulfur atoms · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61K9/0053

  Mouth and digestive tract, i.e. intraoral and peroral administration · CPC title