High frequency neurostimulation for pelvic symptom control

Patent metadata

Field	Value
Publication number	US-11045650-B2
Application number	US-201715831986-A
Country	US
Kind code	B2
Filing date	Dec 5, 2017
Priority date	Dec 6, 2016
Publication date	Jun 29, 2021
Grant date	Jun 29, 2021

Abstract

In general, techniques, methods, systems, and devices for delivering high frequency neurostimulation to control one or more pelvic disorders are described. In one example, a method includes identifying, by a medical device configured to be at least partially implanted in a patient, an indication to inhibit bladder activity. The medical device generates, in response to identifying the indication, electrical stimulation therapy comprising first electrical stimulation pulses comprising a first frequency greater than or equal to about 500 Hertz and less than or equal to about 5,000 Hertz. Further, the medical device delivers the electrical stimulation therapy to a target nerve selected from a group consisting of: a sacral nerve, a pelvic nerve, a tibial nerve, and a pudendal nerve of the patient.

First claim

What is claimed is:

1. A method for delivering electrical stimulation with a medical device configured to be at least partially implanted in a patient, the method comprising:
identifying, by the medical device, an indication to inhibit at least one of a bladder contraction event or a bladder voiding event;
generating, by the medical device and in response to identifying the indication, electrical stimulation therapy comprising first electrical stimulation pulses comprising a first frequency greater than or equal to about 1,000 Hertz and less than or equal to about 5,000 Hertz; and
delivering, by the medical device, the electrical stimulation therapy to a target nerve selected from a group consisting of: a sacral nerve, a pelvic nerve, a tibial nerve, and a pudendal nerve of the patient.

2. The method of claim 1 , wherein the electrical stimulation therapy further comprises second electrical stimulation pulses comprising a second frequency greater than or equal to about 1 Hertz and less than or equal to about 50 Hertz, wherein the second electrical stimulation pulses are interleaved with the first electrical stimulation pulses.

3. The method of claim 2 , wherein identifying the indication comprises detecting, via one or more sensors, a presence or absence of the at least one of the bladder contraction event or the bladder voiding event.

4. The method of claim 3 , further comprising:
delivering, in response to detecting the absence of the at least one of the bladder contraction event or the bladder voiding event, the first electrical stimulation pulses; and
delivering, in response to detecting the at least one of the bladder contraction event or the bladder voiding event of the patient, the second electrical stimulation pulses.

5. The method of claim 4 , further comprising: gradually increasing one of a current amplitude or a voltage amplitude of the second electrical stimulation pulses when transitioning from delivery of the first electrical stimulation pulses to delivery of the second electrical stimulation pulses.

6. The method of claim 4 , wherein the indication to inhibit the at least one of the bladder contraction event or the bladder voiding event comprises
a feedback received from the patient.

7. The method of claim 2 , further comprising:
delivering, by the medical device, the first electrical stimulation pulses and not the second electrical stimulation pulses;
receiving, by the medical device and from an external programmer, feedback from the patient; and
delivering, in response to the feedback and by the medical device, the second electrical stimulation pulses and not the first electrical stimulation pulses.

8. The method of claim 1 , further comprising adjusting the first frequency in response to feedback from the patient.

9. The method of claim 1 , further comprising:
detecting, by sensing circuitry of a medical system comprising the medical device, a spatial location of the patient; and
adjusting the generating of the electrical stimulation therapy comprising the first electrical stimulation pulses based on the detected spatial location of the patient.

10. The method of claim 1 , further comprising:
detecting, by sensing circuitry of a medical system comprising the medical device, a posture of the patient; and
adjusting the generating of the electrical stimulation therapy comprising the first electrical stimulation pulses based on the detected posture of the patient.

11. The method of claim 1 , further comprising:
detecting, by sensing circuitry of a medical system comprising the medical device, a time of day; and
adjusting the generating of the electrical stimulation therapy comprising the first electrical stimulation pulses based on the detected time of day.

12. The method of claim 1 , further comprising:
detecting, by sensing circuitry of a medical system comprising the medical device, electrical activity of a tissue of the patient; and
adjusting the generating of the electrical stimulation therapy comprising the first electrical stimulation pulses based on the detected electrical activity of the tissue of the patient.

13. The method of claim 1 , further comprising:
detecting, by sensing circuitry of a medical system comprising the medical device, a biomarker of the patient indicating at least one of a side effect of delivering the electrical stimulation therapy comprising the first electrical stimulation pulses or an efficacy of a therapeutic effect of delivering the electrical stimulation therapy comprising the first electrical stimulation pulses; and
adjusting the generating of the electrical stimulation therapy comprising the first electrical stimulation pulses based on the detected biomarker of the patient.

14. The method of claim 1 , wherein the target nerve is a sacral nerve of the patient.

15. A medical system comprising a medical device configured to be at least partially implanted in a patient, the medical device comprising:
a lead including one or more electrodes and configured for placement near a target nerve selected from a group consisting of: a sacral nerve, a pelvic nerve, a tibial nerve, and a pudendal nerve of the patient;
electrical stimulation generation circuitry configured to generate electrical stimulation therapy comprising first electrical stimulation pulses comprising a first frequency greater than or equal to about 1,000 Hertz and less than or equal to about 5,000 Hertz; and
processing circuitry configured to:
identify an indication to inhibit at least one of a bladder contraction event or a bladder voiding event; and
control the electrical stimulation generation circuitry to deliver the electrical stimulation therapy to the target nerve via the one or more electrodes.

16. The medical system of claim 15 , wherein the electrical stimulation therapy further comprises second electrical stimulation pulses comprising a second frequency greater than or equal to about 1 Hertz and less than or equal to about 50 Hertz, wherein the second electrical stimulation pulses are interleaved with the first electrical stimulation pulses.

17. The medical system of claim 16 , further comprising one or more sensors, and
wherein, to identify the indication, the processing circuitry is further configured to detect, via the one or more sensors, the at least one of the bladder contraction event or the bladder voiding event, and wherein the processing circuitry is further configured to detect via the one or more sensors, a presence or absence of the at least one of the bladder contraction event or the bladder voiding event.

18. The medical system of claim 17 , wherein the processing circuitry is further configured to:
in response to detecting the absence of the at least one of the bladder contraction event or the bladder voiding event, control the electrical stimulation generation circuitry to deliver the first electrical stimulation pulses; and
in response to detecting the at least one of the bladder contraction event or the bladder voiding event of the patient, delivering, control the electrical stimulation generation circuitry to deliver the second electrical stimulation pulses.

19. The medical system of claim 18 , wherein the processing circuitry is further configured to control the electrical stimulation generation circuitry to gradually increase one of a current amplitude or a voltage amplitude of the second electrical stimulation pulses when transitioning from delivery of the first electrical stimulation pulses to delivery of the second electrical stimulation pulses.

Assignees

• Medtronic Inc

Inventors

• Brink Thaddeus S
• Nelson Dwight E
• Zirpel Lance
• Su Xin
• Hedstrom Blake A
• Peterson Erik J
• Dinsmoor David A

Classifications

• A61B5/1113

  Local tracking of patients, e.g. in a hospital or private home · CPC title

• A61N1/36067

  Movement disorders, e.g. tremor or Parkinson disease (stimulating motor muscle A61N1/36003) · CPC title

• A61N1/37205

  Microstimulators, e.g. implantable through a cannula · CPC title

• A61B5/4836

  Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence) · CPC title

• A61N1/36064

  Epilepsy · CPC title