Softening nerve cuff electrodes

Patent metadata

Field	Value
Publication number	US-11045646-B2
Application number	US-201716304582-A
Country	US
Kind code	B2
Filing date	Jun 26, 2017
Priority date	Jun 27, 2016
Publication date	Jun 29, 2021
Grant date	Jun 29, 2021

Abstract

A nerve cuff electrode device comprising a cuff body having a smart memory polymer layer with a rigid configuration at room temperature and a softened configuration at about 37 C. The smart memory polymer layer has a trained curved region with a radius of curvature of about 3000 microns or less. A plurality of thin film electrodes located on the smart memory polymer layer. The thin film electrodes include discrete titanium nitride electrode sites that are located in the trained curved region. An exposed surface of each of the discrete titanium nitride electrode sites has a charge injection capacity of about 0.1 mC/cm2 or greater. Methods or manufacturing and using the device are also disclosed.

First claim

What is claimed is:

1. A method of manufacturing a nerve cuff electrode device, comprising:
providing a thin film electrode;
forming a smart memory polymer layer on the thin film electrode, including polymerizing monomers of a smart memory polymer on the thin film electrode, wherein the smart memory polymer layer has a rigid configuration at room temperature and a softened configuration at 37° C. and a trained curved region with a radius of curvature of 3000 microns or less;
forming discrete titanium nitride electrode sites on the thin film electrode on the smart memory polymer layer including:
depositing a titanium nitride layer on the thin film electrode, wherein the titanium nitride layer has a charge injection capacity of 0.1 mC/cm 2 or greater and wherein the depositing of the titanium nitride layer includes magnetron sputtering for 15 to 75 minutes.

2. The method of claim 1 , wherein the magnetron sputtering includes magnetron sputtering oxygen with an O 2 concentration in a range from 1×10 −6 to 20 percent.

3. The method of claim 1 , wherein an exposed surface of each of the discrete titanium nitride electrode sites has a charge injection capacity of 2 mC/cm 2 or greater.

4. The method of claim 1 , further including patterning the titanium nitride layer to form the discrete titanium nitride electrode sites, wherein each of the discrete titanium nitride electrode sites has a geometric area of 2 mm 2 or less.

5. The method of claim 1 , further including patterning the titanium nitride layer to form the discrete titanium nitride electrode sites such that each of the discrete titanium nitride electrode sites is located in the trained curved region of the smart memory polymer layer.

6. The method of claim 1 , wherein the monomers of the smart memory polymer layer include a stoichiometric combination of Tris[2-(3-mercaptopropionyloxy)ethyl] isocyanurate and 1,3,5-Triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione combined with 31 mol % Tricyclo[5.2.1.0 2 ′ 6 ] decanedimethanol diacrylate monomers.

7. The method of claim 1 , wherein the magnetron sputtering includes magnetron sputtering oxygen with an O 2 concentration in a range from 5 to 10 percent.

8. The method of claim 1 , wherein the magnetron sputtering includes magnetron sputtering oxygen with an O 2 concentration in a range from 5 to 10 percent.

9. The method of claim 1 , wherein the magnetron sputtering includes magnetron sputtering oxygen with an O 2 concentration in a range from 10 to 20 percent.

10. The method of claim 1 , wherein the discrete titanium nitride electrode sites have a thickness in a range from 5 nm to 200 nm.

11. The method of claim 2 , wherein the titanium nitride layer is a titanium oxynitride layer.

Assignees

• Univ Texas

Inventors

• Modi Romil
• Voit Walter E
• Romero-Ortega Mario

Classifications

• A61B2562/125

  characterised by the manufacture of electrodes · CPC title

• A61N1/0556 Primary

  Cuff electrodes · CPC title

• A61B5/6877

  Nerve · CPC title

• H05K1/118

  specially for flexible printed circuits, e.g. using folded portions · CPC title

• Y10T29/49155

  Manufacturing circuit on or in base · CPC title