Biomedical apparatus with a pressure-regulated blood pump

Patent metadata

Field	Value
Publication number	US-11045640-B2
Application number	US-201716081165-A
Country	US
Kind code	B2
Filing date	Mar 2, 2017
Priority date	Mar 2, 2016
Publication date	Jun 29, 2021
Grant date	Jun 29, 2021

Abstract

A biomedical apparatus for pumping blood of a human or an animal patient through a secondary blood circuit is provided, including a blood pump, an inlet duct and an outlet duct for guiding blood of the patient to the blood pump and back to the patient. The apparatus further includes a measuring device with at least one pressure sensor for measuring pressure values in the patient's circulatory system. A controller is provided that includes at least two different preset control algorithms for regulating the operating point of the blood pump based on the measured pressure values. The controller is configured to select one of these preset control algorithms for being applied in dependence on the position of the at least one pressure sensor in the patient's circulatory system.

First claim

The invention claimed is:

1. A biomedical apparatus for pumping blood of a human or an animal patient through a secondary intra- or extracorporeal blood circuit, comprising:
a blood pump for pumping blood,
an inlet duct connected to the blood pump, for being inserted into a patient's circulatory system, in order to guide blood of the patient to the blood pump,
an outlet duct connected to the blood pump, for being inserted into the patient's circulatory system, in order to guide blood from the blood pump back to the patient's circulatory system,
at least two measuring devices each with at least one pressure sensor for measuring pressure values in the patient's circulatory system, and
a controller for regulating the operating point of the blood pump based on the measured pressure values,
wherein the controller comprises at least two different preset control algorithms for regulating the operating point of the blood pump based on the measured pressure values, and wherein the controller is configured to select one of these preset control algorithms for being applied in dependence on a position of at least one pressure sensor of the at least two measuring devices in the patient's circulatory system.

2. The biomedical apparatus of claim 1 , wherein at least one of the at least two different preset control algorithms causes the controller to determine an estimate for the preload of the heart based on an identification of a minimum of the measured pressure values, in order to regulate the operating point of the blood pump based on this determined estimate for the preload of the heart.

3. The biomedical apparatus of claim 1 , wherein at least one of the at least two different preset control algorithms causes the controller to calculate a temporal mean value of the measured pressure values over at least one cardiac cycle, in order to regulate the operating point of the blood pump based on this calculated temporal mean value.

4. The biomedical apparatus of claim 1 , wherein at least one of the at least two different preset control algorithms causes the controller to identify a pressure at a specific point in time during the cardiac cycle based on the measured pressure values, in order to regulate the operating point of the blood pump based on this identified pressure.

5. The biomedical apparatus as claimed in claim 1 , wherein the at least one pressure sensor is configured to measure the pressure values inside of the left ventricle or the right ventricle of the heart of the patient, and wherein according to at least one preset control algorithm an estimate for a preload of the heart is determined based on an identification of a maximum of the pressure values measured by this pressure sensor inside of the left ventricle or the right ventricle, in order to regulate the operating point of the blood pump based on this determined estimate for the preload of the heart.

6. The biomedical apparatus as claimed in claim 1 , wherein the at least one pressure sensor is configured to measure the pressure values inside of the pulmonary arterial circulation of the patient, and wherein according to at least one preset control algorithm an estimate for the preload of the heart is determined based on an identification of a minimum of the pressure values measured by this pressure sensor inside of the pulmonary arterial circulation, in order to regulate the operating point of the blood pump based on this determined estimate for the preload of the heart.

7. The biomedical apparatus as claimed in claim 1 , wherein the at least one pressure sensor is configured to measure the pressure values inside of the left atrium or the right atrium of the heart or inside of the pulmonary or systemic vein of the patient, and wherein according to at least one preset control algorithm a temporal mean value is calculated of the pressure values measured by this pressure sensor inside of the left atrium or the right atrium or inside of the pulmonary or systemic vein over at least one cardiac cycle, in order to regulate the operating point of the blood pump based on this calculated temporal mean value.

8. The biomedical apparatus as claimed in claim 1 , wherein the at least one pressure sensor is configured to measure the pressure values inside of the left ventricle or the right ventricle of the heart of the patient, and wherein according to at least one preset control algorithm a pressure at a specific point in time during the cardiac cycle is identified based on the pressure values measured by this pressure sensor inside of the left ventricle or the right ventricle, in order to regulate the operating point of the blood pump based on this identified pressure.

9. The biomedical apparatus as claimed in claim 1 , wherein the at least two different preset control algorithms of the controller are at least two of the following four control algorithms:
a first control algorithm, according to which an estimate for the preload of the heart is determined based on an identification of a maximum of the measured pressure values, in order to regulate the operating point of the blood pump based on this determined estimate for the preload of the heart,
a second control algorithm, according to which an estimate for the preload of the heart is determined based on an identification of a minimum of the measured pressure values, in order to regulate the operating point of the blood pump based on this determined estimate for the preload of the heart,
a third control algorithm, according to which a temporal mean value is calculated of the measured pressure values over at least one cardiac cycle, in order to regulate the operating point of the blood pump based on this calculated temporal mean value, and
a fourth control algorithm, according to which a pressure at a specific point in time during the cardiac cycle is identified based on the measured pressure values, in order to regulate the operating point of the blood pump based on this identified pressure.

10. The biomedical apparatus as claimed in claim 9 , wherein the controller is configured to regulate the operating point of the blood pump, such that a linear relationship is established between the estimate for the preload of the heart or the temporal mean value or the pressure at a specific point in time during the cardiac cycle on the one hand and the power of the blood pump on the other hand.

11. The biomedical apparatus as claimed in claim 9 , wherein the biomedical apparatus is a Mechanical Circulatory Support (MCS) device.

12. The biomedical apparatus as claimed in claim 1 , wherein the at least two measuring devices comprises a send-unit and the controller comprises a receive-unit, for wirelessly transmitting a signal that reflects the measured pressure values from the at least one measuring device to the controller.

13. The biomedical apparatus as claimed in claim 1 , wherein the at least two measuring devices is adapted to transmit an identifier to the controller, the identifier reflecting the position of the at least one pressure sensor in the patient's circulatory system.

14. The biomedical apparatus as claimed in claim 13 , wherein the controller is configured to select one of the preset control algorithms for being applied in dependence on the identifier transmitted by the at least two measuring devices.

15. The biomedical apparatus as claimed in claim 1 , further comprising a high-pass filter for filtering a signal that reflects the measured pressure values, wherein the high-pass filter is designed such that a possible long-term drift of the at least one pressure sensor is eliminated from the signal, but that day/night cycles are s

Assignees

• Eth Zuerich

Inventors

• Ochsner Gregor
• Schmid Daners Marianne
• Amacher Raffael
• Meboldt Mirko
• Falk Volkmar
• Petrou Anastasios
• Wilhelm Markus
• Röhrnbauer Barbara

Classifications

• A61M60/113 Primary

  in other functional devices, e.g. dialysers or heart-lung machines · CPC title

• A61M60/857

  Implantable blood tubes · CPC title

• A61M60/824

  Hydrodynamic or fluid film bearings · CPC title

• A61M60/82

  Magnetic bearings · CPC title

• A61M60/562

  for making blood flow pulsatile in blood pumps that do not intrinsically create pulsatile flow · CPC title