Membrane for immunoisolation, chamber for transplantation, and device for transplantation

Patent metadata

Field	Value
Publication number	US-11045587-B2
Application number	US-201916408894-A
Country	US
Kind code	B2
Filing date	May 10, 2019
Priority date	Nov 11, 2016
Publication date	Jun 29, 2021
Grant date	Jun 29, 2021

Abstract

According to the present invention, there is provided a membrane for immunoisolation, including a porous membrane that contains a polymer, in which Formulas (I) and (II) are satisfied for at least one surface of the porous membrane, B/A≤0.7 (I) and A≥0.015 (II) (in the formula, A represents a ratio of an N element to a C element on a surface of the membrane, and B represents a ratio of the N element to the C element at a depth of 30 nm from the surface of the membrane); a chamber for transplantation for enclosing a biological constituent therein, including the above-described membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation; and a device for transplantation includes the above-described chamber for transplantation enclosing the above-described biological constituent therein. The membrane for immunoisolation of the present invention has a high bioaffinity.

First claim

What is claimed is:

1. A membrane for immunoisolation, comprising:
a porous membrane that contains a polymer,
wherein Formulas (I) and (II) are satisfied for at least one surface of the porous membrane,
B/A≤ 0.7  (I)

A≥ 0.015  (II)

in the formula, A represents a ratio of an N element to a C element on a surface of the membrane, and B represents a ratio of the N element to the C element at a depth of 30 nm from the surface of the membrane,
wherein the porous membrane has a minimum pore diameter of 0.45 μm to 1.5 μm.

2. The membrane for immunoisolation according to claim 1 , wherein Formulas (I) and (II) are satisfied for both surfaces of the porous membrane.

3. The membrane for immunoisolation according to claim 1 , which is made from the porous membrane.

4. The membrane for immunoisolation according to claim 1 , wherein the porous membrane contains 0.05% to 8.0% by mass of a nitrogen-containing compound with respect to a mass of the porous membrane.

5. The membrane for immunoisolation according to claim 4 , wherein the nitrogen-containing compound is a polyvinylpyrrolidone.

6. The membrane for immunoisolation according to claim 1 , wherein the porous membrane contains a polysulfone.

7. The membrane for immunoisolation according to claim 1 , wherein the porous membrane has a thickness of 10 μm to 250 μm.

8. The membrane for immunoisolation according to claim 1 , wherein the porous membrane has a minimum pore diameter of 0.45 μm to 1.3 μm.

9. The membrane for immunoisolation according to claim 1 ,
wherein the porous membrane has a layered compact portion where a pore diameter is smallest within the membrane, and
the pore diameter continuously increases in a thickness direction from the compact portion toward at least one surface of the porous membrane.

10. The membrane for immunoisolation according to claim 9 , wherein a thickness of the compact portion is 0.5 μm to 30 μm.

11. The membrane for immunoisolation according to claim 9 , wherein the compact portion is located between any one surface X of the porous membrane and a portion at a distance of one-third the thickness of the porous membrane from the surface X,
wherein the surface X is the surface of the porous membrane closer to the compact portion.

12. The membrane for immunoisolation according to claim 11 , wherein Formulas (I) and (II) are satisfied for the surface X.

13. The membrane for immunoisolation according to claim 1 , wherein the porous membrane comprises polysulfone, polyvinylpyrrolidone, and lithium chloride.

14. A chamber for transplantation for enclosing a biological constituent therein, the chamber comprising:
a membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation,
wherein the membrane for immunoisolation comprises:
a porous membrane that contains a polymer,
wherein Formulas (I) and (II) are satisfied for at least one surface of the porous membrane,
B/A≤ 0.7  (I)

A≥ 0.015  (II)

in the formula, A represents a ratio of an N element to a C element on a surface of the membrane, and B represents a ratio of the N element to the C element at a depth of 30 nm from the surface of the membrane.

15. The chamber for transplantation according to claim 14 , wherein the surface satisfying Formulas (I) and (II) is on the inside.

16. The chamber for transplantation according to claim 14 ,
wherein the porous membrane has a layered compact portion where a pore diameter is smallest within the membrane,
the pore diameter continuously increases in a thickness direction from the compact portion toward at least one surface of the porous membrane,
wherein the compact portion is located between any one surface X of the porous membrane and a portion at a distance of one-third the thickness of the porous membrane from the surface X,
wherein the surface X is the surface of the porous membrane closer to the compact portion, and
wherein the surface X of the porous membrane is on the inside.

17. The chamber for transplantation according to claim 14 , wherein the biological constituent is a cell.

18. A device for transplantation comprising:
the chamber for transplantation according to claim 14 enclosing the biological constituent therein.

19. The device for transplantation according to claim 18 , wherein the biological constituent releases a physiologically active substance.

20. The device for transplantation according to claim 19 , wherein the physiologically active substance is insulin.

Assignees

• Fujifilm Corp

Inventors

• Mochizuki Yusuke
• Nakamura Kentaro
• Ohtani Shigeaki
• Matsunaga Naohiro
• Takegami Ryuta

Classifications

• A61F2/022 Primary

  Artificial gland structures using bioreactors (hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36) · CPC title

• A61F2/02

  Prostheses implantable into the body · CPC title

• A61L31/14

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L31/04

  Macromolecular materials · CPC title

• A61L27/18

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title