Artificial cornea and method for manufacturing the artificial cornea

Patent metadata

Field	Value
Publication number	US-11045308-B2
Application number	US-201816016609-A
Country	US
Kind code	B2
Filing date	Jun 24, 2018
Priority date	Mar 28, 2018
Publication date	Jun 29, 2021
Grant date	Jun 29, 2021

Abstract

Provided are an artificial cornea having sufficient strength and optical properties, in which deviation or infection of the artificial cornea is restrained, and a method for manufacturing the artificial cornea. According to the present invention, the method for manufacturing the artificial cornea includes a nonwoven fabric preparation step of preparing a nonwoven fabric formed therein with a through-hole, and a gel arrangement step of arranging an aqueous polymer gel to cover the through-hole.

First claim

What is claimed is:

1. A method for manufacturing an artificial cornea, the method comprising:
a nonwoven fabric preparation step of preparing a nonwoven fabric formed therein with a through-hole; and
a gel arrangement step of arranging an aqueous polymer gel to cover the through-hole;
wherein the nonwoven fabric includes a composite nanofiber of polyvinyl alcohol, hydroxyethyl cellulose, and graphite (PVA-HEC-GR).

2. The method of claim 1 , wherein the nonwoven fabric is formed through an electrospinning scheme using a spinning solution as a source material obtained by dispersing the graphite in a mixed solution of the polyvinyl alcohol and the hydroxyethyl cellulose.

3. The method of claim 1 , wherein a hydroxyapatite (HA) is attached to the nonwoven fabric.

4. The method of claim 1 , wherein the aqueous polymer gel includes a polyvinyl alcohol-based aqueous polymer gel.

5. The method of claim 4 , wherein the gel arrangement step comprises arranging the aqueous polymer gel on the nonwoven fabric by a freeze-thawing scheme.

6. A method for manufacturing an artificial cornea, the method comprising:
a nonwoven fabric preparation step of preparing a nonwoven fabric formed therein with a through-hole; and
a gel arrangement step of arranging an aqueous polymer gel to cover the through-hole;
wherein the nonwoven fabric preparation step comprises attaching a hydroxyapatite to the nonwoven fabric by performing one time or several times of a cycle of immersing the nonwoven fabric in an aqueous solution of calcium chloride, and immersing the nonwoven fabric in an aqueous solution of disodium phosphate (DSP) (Na 2 HPO 4 ) adjusted to pH 10 or more.

Assignees

• Lemon Co Ltd
• Univ Shinshu

Inventors

• Kim Ik Soo
• Kharaghani Davood
• Hijiri Ohtani

Classifications

• D01F1/10

  Other agents for modifying properties · CPC title

• A61L2430/16

  for reconstruction of eye parts, e.g. intraocular lens, cornea · CPC title

• D06M2101/24

  Polymers or copolymers of alkenylalcohols or esters thereof; Polymers or copolymers of alkenylethers, acetals or ketones · CPC title

• A61F2230/0006

  circular · CPC title

• D10B2321/06

  polymers of unsaturated alcohols, e.g. polyvinyl alcohol, or of their acetals or ketals · CPC title