T cell receptors that are specific to a fluorescent protein, transgenic animals and methods of their making, isolated t cells, and methods of use
US-2016219844-A1 · Aug 4, 2016 · US
Human alpha fetoprotein-specific murine T cell receptors and uses thereof
US11041011B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11041011-B2 |
| Application number | US-201815969211-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 2, 2018 |
| Priority date | May 12, 2017 |
| Publication date | Jun 22, 2021 |
| Grant date | Jun 22, 2021 |
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Abstract
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T cell receptors that specifically recognize hAFP 158 and methods of their use are provided.
First claim
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We claim: 1. A recombinant T cell receptor (TCR) comprising: a) a Vα domain comprising an amino acid sequence set forth SEQ ID NO:16; and b) a Vβ domain comprising an amino acid sequence set forth in SEQ ID NO:24. 2. The recombinant T cell receptor of claim 1 , wherein the TCR is a humanized TCR. 3. A recombinant T cell receptor (TCR) polypeptide or protein comprising at least one Vα chain polypeptide and at least one Vβ chain polypeptide, wherein the Vα chain polypeptide comprises an amino acid sequence set forth in SEQ ID NO: 3, and the Vβ chain polypeptide comprises an amino acid sequence set forth in SEQ ID NO: 11, wherein the TCR specifically binds to an HLA-A2/hAFP 158 (SEQ ID NO: 1) complex.
Assignees
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Classifications
Alpha-feto protein · CPC title
T-cell receptors [TCR] · CPC title
T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells · CPC title
Liver · CPC title
characterised by the dose, timing or administration schedule · CPC title
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- What does patent US11041011B2 cover?
- T cell receptors that specifically recognize hAFP 158 and methods of their use are provided.
- Who is the assignee on this patent?
- Univ Res Inst Inc Augusta, Nat Institutes Of Health Nih, U S Dept Of Health And Human Services Dhhs, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07K14/7051. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 22 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).