System, method and apparatus for minimizing dead legs in a bioreactor system

Patent metadata

Field	Value
Publication number	US-11040867-B2
Application number	US-201816143827-A
Country	US
Kind code	B2
Filing date	Sep 27, 2018
Priority date	Sep 27, 2018
Publication date	Jun 22, 2021
Grant date	Jun 22, 2021

Abstract

An apparatus for minimizing dead leg spaces in a container or tubing includes a first member having a flange for attaching the first member to a wall of the container or tubing, the flange having at least one aperture, and a second member rotatably coupled to the first member, the second member having an upper end having at least one aperture, and an open distal end. The second member is rotatable relative to the first member between a closed position where the at least one aperture of the second member is misaligned with the at least one aperture in the flange to prevent the passage of fluid, and an open position where the at least one aperture of the second member is aligned with the at least one aperture in the flange to allow for the passage of fluid.

First claim

What is claimed is:

1. An apparatus for minimizing dead leg spaces in a container or tubing, comprising:
a first member having a flange for attaching the first member to a wall of the container or tubing and a hollow stem extending downwardly from the flange and having a central axis that is perpendicular to the flange, the flange having a top, upwardly-facing surface and at least one aperture in the top surface; and
a second member having a tubular body portion having a top, upwardly-facing surface and at least one aperture in the top surface, and an open distal end, the second member being rotatably coupled to the first member;
wherein the second member is rotatable relative to the first member between a closed position where the at least one aperture of the second member is misaligned with the at least one aperture in the flange to prevent the passage of fluid, and an open position where the at least one aperture of the second member is aligned with the at least one aperture in the flange to allow for the passage of fluid;
wherein the second member is axially fixed with respect to the first member such that during rotation of the second member relative to the first member, an axial position of the second member with respect to the first member is maintained.

2. The apparatus of claim 1 , wherein:
the first member includes a pair of resilient arms each having a distal end that projects inwardly toward the central axis; and
the second member includes a circumferential groove that extends substantially entirely around the second member;
wherein the resilient arms engage the circumferential groove and facilitate rotation of the second member between the open position and the closed position.

3. The apparatus of claim 2 , wherein:
the circumferential groove includes at least one position stop, the at least one position stop limiting rotation of the second member with respect to the first member.

4. The apparatus of claim 3 , wherein:
the at least one position stop is located such that rotation of second member to a position where one of the resilient arms contacts the position stop corresponds to the open position of the apparatus.

5. The apparatus of claim 1 wherein:
the distal end of the second member includes a hose barb connector for connecting drain tubing to the apparatus.

6. The apparatus of claim 1 , wherein:
the container or tubing is a flexible, single-use bioprocessing bag.

7. The apparatus of claim 1 , wherein:
the top surface of the tubular body portion of the second member is generally coplanar with the top surface of the flange in both the closed position and the open position.

8. The apparatus of claim 1 , wherein:
the hollow stem of the first member and the tubular body portion of the second member define therethrough a hollow passageway defining an axial direction; and
wherein in the open position, the aperture in the flange of the first member and the aperture in the top surface of the tubular body portion of the second member are aligned in the axial direction.

Assignees

• Global Life Sciences Solutions Usa Llc

Inventors

• Saukkonen Hanna-Leena
• Brown Benjamin
• Ouellette Matthew
• Jones Shanice
• Stankowski Ralph
• Faldt Eric
• Lisle Lauren

Classifications

• C12M39/00 Primary

  Means for cleaning the apparatus or avoiding unwanted deposits of microorganisms (apparatus for cleaning laboratory receptacles or instruments B01L13/02; cleaning in general B08B) · CPC title

• C12M23/38 Primary

  Caps; Covers; Plugs; Pouring means · CPC title

• C12M23/14

  Bags · CPC title

• C12M23/26

  flexible (flexible containers for laboratory use B01L3/505) · CPC title

• B67D7/36 Primary

  Arrangements of flow- or pressure-control valves (associated with nozzles B67D7/42) · CPC title