Antimicrobial glass compositions, glasses and polymeric articles incorporating the same

Patent metadata

Field	Value
Publication number	US-11039619-B2
Application number	US-201715446223-A
Country	US
Kind code	B2
Filing date	Mar 1, 2017
Priority date	Feb 19, 2014
Publication date	Jun 22, 2021
Grant date	Jun 22, 2021

Abstract

Embodiments of the present invention pertain to antimicrobial glass compositions, glasses and articles. The articles include a glass, which may include a glass phase and a cuprite phase. In other embodiments, the glasses include as plurality of Cu1+ ions, a degradable phase including B2O3, P2O5 and K2O and a durable phase including SiO2. Other embodiments include glasses having a plurality of Cu1+ ions disposed on the surface of the glass and in the glass network and/or the glass matrix. The article may also include a polymer. The glasses and articles disclosed herein exhibit a 2 log reduction or greater in a concentration of at least one of Staphylococcus aureus, Enterobacter aerogenes, Pseudomonas aeruginosa bacteria, Methicillin Resistant Staphylococcus aureus, and E. coli, under the EPA Test Method for Efficacy of Copper Alloy as a Sanitizer testing conditions and under Modified JIS Z 2801 for Bacteria testing conditions. In some embodiments, the glass and articles exhibit a 2 log reduction or greater in a concentration of Murine Norovirus under Modified JIS Z 2801 Test for Viruses testing conditions.

First claim

What is claimed is:

1. An article comprising:
a carrier comprising a polymer or a monomer; and
a glass comprising, in mole percent, SiO 2 in the range from about 40 to about 70 and Al2O3 in the range from about 10 to about 20, at least one of B 2 O 3 , P 2 O 5 , alkaline earth oxides, and R 2 O, and a plurality of Cu 1+ ions,
wherein R is any one or more of K, Na, Li, Rb and Cs,
wherein a portion of the plurality of Cu 1+ ions leach from the glass when the glass is exposed to or in contact with a leachate,
wherein the leachate is water,
wherein the plurality of Cu 1+ ions is provided in the glass as a copper-containing oxide,vwherein the glass is provided as particulates or as fibers and
further wherein the amount of the copper-containing oxide exceeds the amount of Al 2 O 3 in mole percent.

2. The article of claim 1 , wherein the polymer comprises one of polycarbonate, nylon, polycarbonate and poly(acrylonitrile-butadiene-styrene) blends, poly(acrylonitrile-butadiene-styrene), polybutyleneterephthlate, polyethyleneterephthalate, polyethyleneterephthalate copolymers, polyphenylene oxide, polyvinylchloride, and acrylic polymers, and further wherein the monomer comprises one of a catalyst-curable monomer, a thermally-curable monomer, a radiation-curable monomer and combinations thereof.

3. The article of claim 2 , wherein the polymer comprises a thermosetting polymer.

4. The article of claim 1 , further exhibiting any one or more of
a 2 log reduction or greater in a concentration of any one or more of Staphylococcus aureus, Enterobacter aerogenes, Pseudomomas aeruginosa , Methicillin Resistant Staphylococcus aureus , and E. coli , under EPA Test Method for Efficacy of Copper Alloy as a Sanitizer testing conditions,
a 4 log reduction or greater in a concentration of any one or more of Staphylococcus aureus, Enterobacter aerogenes, Pseudomomas aeruginosa bacteria, Methicillin Resistant Staphylococcus aureus , and E. coli , under JIS Z 2801 (2000) testing conditions or a Modified JIS Z 2801 Test for Bacteria, and
a 4 log reduction or greater in a concentration of Murine Norovirus under a Modified JIS Z 2801 Test for Viruses.

5. The article of claim 1 , wherein the copper-containing oxide comprises Cu 2 O.

6. The article of claim 1 , wherein the glass is substantially free of tenorite.

7. The article of claim 1 , wherein the glass comprises a first phase and a cuprite phase, wherein the cuprite phase comprises crystals having an average major dimension of about 5 micrometers (μm) or less, wherein the first phase comprises at least one of B 2 O 3 , P 2 O 5 and R 2 O, and further wherein R is any one or more of K, Na, Li, Rb and Cs.

8. A method of making an antimicrobial article comprising:
melting a glass composition to form a glass comprising a cuprite phase comprising a plurality of Cu 1+ ions; and a first phase comprising, in mole percent, SiO 2 in the range from about 40 to about 70 and Al 2 O 3 in the range from about 10 to about 20, at least one of B 2 O 3 , P 2 O 5 , alkaline earth oxides, and R 2 O;
forming the glass into at least one of particulates and fibers;
dispersing the at least one of particulates and fibers in a polymer to provide a filled polymer; and
forming the filled polymer into the antimicrobial article,
wherein R is any one or more of K, Na, Li, Rb and Cs,
wherein a portion of the plurality of Cu 1+ ions leach from the glass when the glass is exposed to or in contact with a leachate,
wherein the leachate is water,
wherein the plurality of Cu 1+ ions is provided in the glass as a copper-containing oxide, and
further wherein the amount of the copper-containing oxide exceeds the amount of Al 2 O 3 in mole percent.

9. An article comprising:
a carrier comprising a polymer or a monomer;
a glass comprising, in mole percent, SiO 2 in the range from about 40 to about 70 and Al 2 O 3 in the range from about 10 to about 20, at least one of B 2 O 3 , P 2 O 5 , alkaline earth oxides, and R 2 O, and a plurality of Cu 1+ ions; and
one or more pigments to impart color in the article,
wherein R is any one or more of K, Na, Li, Rb and Cs,
wherein a portion of the plurality of Cu 1+ ions leach from the glass when the glass is exposed to or in contact with a leachate,
wherein the leachate is water,
wherein the plurality of Cu 1+ ions is provided in the glass as a copper-containing oxide, wherein the glass is provided as particulates or as fibers and
further wherein the amount of the copper-containing oxide exceeds the amount of Al 2 O 3 in mole percent.

10. The article of claim 9 , wherein the polymer comprises one of polycarbonate, nylon, polycarbonate and poly(acrylonitrile-butadiene-styrene) blends, poly(acrylonitrile-butadiene-styrene), polybutyleneterephthlate, polyethyleneterephthalate, polyethyleneterephthalate copolymers, polyphenylene oxide, polyvinylchloride, and acrylic polymers, and further wherein the monomer comprises one of a catalyst-curable monomer, a thermally-curable monomer, a radiation-curable monomer and combinations thereof.

11. The article of claim 10 , wherein the polymer comprises a thermosetting polymer.

12. The article of claim 9 , further exhibiting any one or more of
a 2 log reduction or greater in a concentration of any one or more of Staphylococcus aureus, Enterobacter aerogenes, Pseudomomas aeruginosa , Methicillin Resistant Staphylococcus aureus , and E. coli , under EPA Test Method for Efficacy of Copper Alloy as a Sanitizer testing conditions,
a 4 log reduction or greater in a concentration of any one or more of Staphylococcus aureus, Enterobacter aerogenes, Pseudomomas aeruginosa bacteria, Methicillin Resistant Staphylococcus aureus , and E. coli , under JIS Z 2801 (2000) testing conditions or a Modified JIS Z 2801 Test for Bacteria, and
a 4 log reduction or greater in a concentration of Murine Norovirus under a Modified JIS Z 2801 Test for Viruses.

13. The article of claim 9 , wherein the copper-containing oxide comprises Cu 2 O.

14. The article of claim 9 , wherein the glass is substantially free of tenorite.

15. The article of claim 9 , wherein the glass comprises a first phase and a cuprite phase, wherein the cuprite phase comprises crystals having an average major dimension of about 5 micrometers (μm) or less, wherein the first phase comprises at least one of B 2 O 3 , P 2 O 5 and R 2 O, and further wherein R is any one or more of K, Na, Li, Rb and Cs.

Assignees

• Corning Inc

Inventors

• Bookbinder Dana Craig
• Calabrese Gary Stephen
• Gross Timothy Michael
• Jiang Dayue
• Wang Jianguo

Classifications

• C08K3/40

  Glass · CPC title

• C04B14/24

  porous, e.g. foamed glass · CPC title

• C03C2204/02

  Antibacterial glass, glaze or enamel · CPC title

• C03C12/00

  Powdered glass (C03C8/02 takes precedence); Bead compositions · CPC title

• C03C10/0009

  containing silica as main constituent · CPC title