Methods and materials for treating cancer

Patent metadata

Field	Value
Publication number	US-11034773-B2
Application number	US-201916726571-A
Country	US
Kind code	B2
Filing date	Dec 24, 2019
Priority date	Jan 28, 2016
Publication date	Jun 15, 2021
Grant date	Jun 15, 2021

Abstract

This document provides methods and materials related to treating cancer. For example, methods and materials for using particles (e.g., nanoparticles) containing (a) one or more molecules having the ability to bind to a cancer cell (e.g., a human breast cancer cell) and (b) one or more molecules having the ability to bind to an APC (e.g., a human macrophage) to treat cancer are provided.

First claim

What is claimed is:

1. A method for treating a mammal having cancer, said method comprising administering to said mammal a composition comprising particles, wherein said particles have a longest dimension of 1000 nm or less and comprise (a) an anti-cancer antigen antibody and (b) calreticulin, wherein incubation of cancer cells and said antigen presenting cells in the presence of said composition results in increased phagocytosis of said cancer cells by said antigen presenting cells as compared to the level of phagocytosis of comparable cancer cells by comparable antigen presenting cells in the absence of said composition,
wherein said anti-cancer antigen antibody is conjugated to a surface of said particles,
wherein said calreticulin is conjugated to a surface of said particles, and
wherein said anticancer antigen antibody is an anti-CD340 antibody, an anti-EGFR antibody, an anti-PSMA antibody, an anti-EGFRviii antibody, an anti-CEA antibody, an anti-CA125 antibody, an anti-CD20 antibody, an anti-CD30 antibody, an anti-CD33 antibody, or an anti-GD antibody.

2. The method of claim 1 , wherein said mammal is a human.

3. The method of claim 1 , wherein said cancer is breast cancer, brain cancer, prostate cancer, lung cancer, or colorectal cancer.

4. The method of claim 1 , wherein said composition is administered by injection, ingestion, or inhalation.

Assignees

• Mayo Found Medical Education & Res

Inventors

• Kim Yon Son Betty
• Wharen Jr Robert E
• Yuan Hengfeng
• Jiang Wen

Classifications

• A61K9/51

  Nanocapsules; {Nanoparticles; (nanotubes A61K9/0092; polymeric micelles A61K9/1075; polymersomes A61K9/1273; pure drug nanoparticles A61K9/14; drug nanoparticles with adsorbed surface modifiers A61K9/141; conjugates, e.g. between drug and non-active nanoparticles, A61K47/50; preparations for in vivo diagnosis A61K49/00; with radioactive substances A61K51/00)} · CPC title

• C07K16/2866

  against receptors for cytokines, lymphokines, interferons · CPC title

• A61K38/1738

  Calcium binding proteins, e.g. calmodulin · CPC title

• C07K16/32 Primary

  against translation products of oncogenes · CPC title

• A61K47/6933

  the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol · CPC title