Alpha-cinnamide compounds and compositions as hdac8 inhibitors
US-2016264518-A1 · Sep 15, 2016 · US
US11034650B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11034650-B2 |
| Application number | US-201716472001-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 22, 2017 |
| Priority date | Dec 23, 2016 |
| Publication date | Jun 15, 2021 |
| Grant date | Jun 15, 2021 |
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The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).
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The invention claimed is: 1. A compound according to formula A: or a stereoisomer, pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of No A L M 1 cyclopropylamine —CH 2 — meta phenyl 2 (CH 3 ) 2 CHNH— —CH 2 — meta phenyl 3 CH 2 CHCH 2 NH— —CH 2 — meta phenyl 4 (CH 3 ) 3 CCH 2 NH— —CH 2 — meta phenyl 5 CH 3 O(CH 2 ) 2 NH— —CH 2 — meta phenyl 6 (CH 3 ) 2 N(CH 2 ) 2 NH— —CH 2 — meta phenyl 7 CO 2 HCH 2 NH— —CH 2 — meta phenyl 8 (C 2 H 5 ) 2 N— —CH 2 — meta phenyl 9 morpholine —CH 2 — meta phenyl 10 4-tert-butyl-piperidine —CH 2 — meta phenyl 11 4-phenyl-piperidine —CH 2 — meta phenyl 12 4-phenyl-piperazine —CH 2 — meta phenyl 13 1-(pyridin-2-yl)-piperazine —CH 2 — meta phenyl 14 1,2,3,4-tetrahydro- —CH 2 — meta phenyl isoquinoline 15 heliamine —CH 2 — meta phenyl 16 benzylamine —CH 2 — meta phenyl 17 N-methylbenzylamine —CH 2 — meta phenyl 18 4-chlorobenzylamine —CH 2 — meta phenyl 19 4-methoxybenzylamine —CH 2 — meta phenyl 20 4-dimethylaminobenzylamine —CH 2 — meta phenyl 21 4-trifluoromethylbenzylamine —CH 2 — meta phenyl 22 4-pyridylmethanamine —CH 2 — meta phenyl 23 3,4-dimethylbenzylamine —CH 2 — meta phenyl 24 cyclopropylamine —CH 2 — meta phenyl 25 (CH 3 ) 2 CHNH— —CH 2 — meta phenyl 26 CH 2 CHCH 2 NH— —CH 2 — meta phenyl 27 (CH 3 ) 3 CCH 2 NH— —CH 2 — meta phenyl 28 CH 3 O(CH 2 ) 2 NH— —CH 2 — meta phenyl 29 (CH 3 ) 2 N(CH 2 ) 2 NH— —CH 2 — meta phenyl 30 CO 2 HCH 2 NH— —CH 2 — meta phenyl 31 (C 2 H 5 ) 2 N— —CH 2 — meta phenyl 32 morpholine —CH 2 — meta phenyl 33 1,1-dioxo-thiomorpholine —CH 2 — meta phenyl 34 4-tert-butyl-piperidine —CH 2 — meta phenyl 35 4-phenyl-piperidine —CH 2 — meta phenyl 36 4-phenyl-piperazine —CH 2 — meta phenyl 37 1-(pyridin-2-yl)-piperazine —CH 2 — meta phenyl 38 1,2,3,4-tetrahydro- —CH 2 — meta phenyl isoquinoline 39 heliamine —CH 2 — meta phenyl 40 benzylamine —CH 2 — meta phenyl 41 N-methylbenzylamine —CH 2 — meta phenyl 42 4-chlorobenzylamine —CH 2 — meta phenyl 43 4-methoxybenzylamine —CH 2 — meta phenyl 44 4-dimethylaminobenzylamine —CH 2 — meta phenyl 45 4-trifluoromethylbenzylamine —CH 2 — meta phenyl 46 4-pyridylmethanamine —CH 2 — meta phenyl 47 3,4-dimethylbenzylamine —CH 2 — meta phenyl 48 (CH 3 ) 2 CHNH— —CH 2 — meta phenyl 49 CH 2 CHCH 2 NH— —CH 2 — meta phenyl 50 (CH 3 ) 3 CCH 2 NH— —CH 2 — meta phenyl 51 CH 3 O(CH 2 ) 2 NH— —CH 2 — meta phenyl
having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms · CPC title
The ring being saturated · CPC title
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title
Drugs for disorders of the respiratory system · CPC title
Amides · CPC title
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