Small molecule inhibitors of fibrosis
US-2017362211-A1 · Dec 21, 2017 · US
US11028078B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11028078-B2 |
| Application number | US-201816152008-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 4, 2018 |
| Priority date | Sep 7, 2011 |
| Publication date | Jun 8, 2021 |
| Grant date | Jun 8, 2021 |
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Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
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What is claimed is: 1. A compound selected from: Compund Structure Number 214 215 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 2. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 , and a pharmaceutically acceptable carrier.
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title
containing three or more hetero rings · CPC title
not condensed and containing further heterocyclic rings · CPC title
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