Single-use manifolds for automated, aseptic handling of solutions in bioprocessing applications
US-9700844-B2 · Jul 11, 2017 · US
US11027108B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11027108-B2 |
| Application number | US-201816189898-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 13, 2018 |
| Priority date | Nov 14, 2017 |
| Publication date | Jun 8, 2021 |
| Grant date | Jun 8, 2021 |
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A fluid transfer assembly is described. The fluid transfer assembly includes a unitary junction having an upstream portion and a downstream portion, the unitary junction defining a plurality of curved fluid pathways between the upstream portion and the downstream portion. The assembly also includes at least one flexible fluid conduit sealed to the junction in fluid communication with at least one of the plurality of curved fluid pathways.
Opening claim text (preview).
The invention claimed is: 1. A fluid transfer assembly, comprising: a unitary junction having an upstream portion and a downstream portion, the unitary junction defining a plurality of curved fluid pathways between the upstream portion and the downstream portion, each of the curved fluid pathways defining a central axis along a length thereof, the central axis comprising a linear first segment, a curved second segment, and a linear third segment, the second segment disposed between the first and third segments, the second segment of the central axis deviating from a straight line to define a smooth curve, a linear projection of the first segment intersecting a linear projection of the third segment outside of the respective curved fluid pathway or the first and third segments being parallel to one another; and at least one flexible fluid conduit sealed to the junction in fluid communication with at least one of the plurality of curved fluid pathways, wherein fluid is transferred from a primary vessel to a secondary vessel through the unitary junction. 2. The fluid transfer assembly of claim 1 , wherein the plurality of fluid pathways from the upstream portion to the downstream portion are free from diaphragm capable of restricting or stopping flow. 3. The fluid transfer assembly of claim 1 , wherein the junction comprises a hollow cavity independent of the plurality of fluid pathways. 4. The fluid transfer assembly of claim 1 , further comprising at least one additional component comprising at least one of a vessel, a fitting, and a connector. 5. The fluid transfer assembly of claim 1 , wherein the unitary junction is formed from a plurality of layers of material. 6. The fluid transfer assembly of claim 5 , wherein of the plurality of layers is each layer being approximately the same thickness. 7. The fluid transfer assembly of claim 1 , wherein: the junction comprises a common pathway portion that provides a portion of at least two of the plurality of curved fluid pathways. 8. The fluid transfer assembly of claim 7 , wherein: the common pathway portion is arranged such that a number of apertures on the downstream portion is not equal to a number of apertures on the upstream portion. 9. The fluid transfer assembly of claim 1 , wherein the upstream portion of the downstream portion includes a connector assembly for coupling the junction to a barbed connector of the supply vessel, and wherein the connector assembly includes a stem and a peripheral wall at least partially surrounding the stem for facilitating attachment of the unitary junction to the barbed connector. 10. The fluid transfer assembly of claim 9 , wherein the connection assembly includes a fitting for engaging the barbed connector and the peripheral wall, wherein the fitting includes a body with a plurality of locking features extending therefrom and configured to engage at least a portion of the unitary junction. 11. The fluid transfer assembly of claim 10 , wherein the unitary junction is formed by digital light synthesis using patterns of light to at least partially cure the unitary junction layer by layer with uncured material being cured to a bottom of a stack as a body of cured or semi-cured material is lifted from a reservoir of uncured material. 12. The fluid transfer assembly of claim 1 , wherein at least one of the upstream portion and the downstream portion comprises a plurality of male inserts respectively corresponding with the plurality of fluid pathways, the plurality of male inserts for insertion into the at least one fluid conduit to facilitate fluid communication. 13. The fluid transfer assembly of claim 12 , wherein the at least one fluid conduit comprises a plurality of lumen equal to the plurality of male inserts such that each insert engages a respective lumen of the at least one fluid conduit. 14. The fluid transfer assembly of claim 12 , wherein the plurality of male inserts are substantially parallel with one another. 15. The fluid transfer assembly of claim 12 , wherein the plurality of male inserts are arranged radially around a central axis of the junction. 16. The fluid transfer assembly of claim 15 , wherein the junction comprises indicia adjacent to a single one of the plurality of male inserts, the indicia adjacent to the single one of the male inserts that corresponds with a fluid pathway accessible along the central axis of the junction. 17. The fluid transfer assembly of claim 12 , wherein the junction comprises a peripheral wall that surrounds the plurality of male inserts. 18. The fluid transfer assembly of claim 17 , wherein a curable material is contained by the peripheral wall and attaches the at least one flexible fluid conduit to the junction. 19. The fluid transfer assembly of claim 17 , wherein the peripheral wall is scalloped. 20. A fluid transfer assembly, comprising: a unitary junction having an upstream portion and a downstream portion, the unitary junction including walls defining a plurality of curved fluid pathways between the upstream portion and the downstream portion, each of the curved fluid pathways defining a central axis, the walls defining each curved fluid pathway comprising a linear first section, a curved second section, and a linear third section disposed between the first section and the third section, the second section defining a segment of the central axis having a smooth curve along a length thereof, the second section having a length along the central axis greater than a diameter of the curved fluid pathway; at least one flexible fluid conduit sealed to the junction in fluid communication with at least one of the plurality of curved fluid pathways; and at least one vessel connected to the at least one flexible fluid conduit, wherein at least one of the upstream portion and the downstream portion comprises a plurality of male inserts respectively corresponding with the plurality of fluid pathways, the plurality of male inserts for insertion into the at least one fluid conduit to facilitate fluid communication. 21. The fluid transfer assembly of claim 20 , wherein the at least one vessel includes a bag, beaker, bottle, canister, flask, tank, vat, vial, tube, syringe, or combinations thereof. 22. The fluid transfer assembly of claim 20 , wherein the unitary junction is formed from a plurality of layers of material, each layer being approximately the same thickness. 23. The fluid transfer assembly of claim 20 , wherein the unitary junction comprises a hollow cavity independent of the plurality of fluid pathways. 24. The fluid transfer assembly of claim 20 , wherein: the junction comprises a common pathway portion that forms part of at least two of the plurality of curved fluid pathways, wherein the common pathway portion is arranged such that a number of access points on the downstream portion is not equal to a number of access points on the upstream portion. 25. The fluid transfer assembly of claim 20 , wherein the junction comprises a peripheral wall that surrounds the plurality of male inserts, where in a curable material is contained by the peripheral wall and attaches the at least one flexible fluid conduit to the junction. 26. The fluid transfer assembly of claim 20 , wherein the at least one flexible fluid conduit comprises a plurality of lumen equal to the plurality of male inserts such that each insert engages a respective lumen of the at least one flexible
Multi-channel connectors or couplings, e.g. for connecting multi-lumen tubes (multi-channel connectors in general F16L37/56) · CPC title
having a plurality of male connectors, e.g. Luer connectors · CPC title
Adapters, e.g. couplings adapting a connector to one or several other connectors · CPC title
Closing · CPC title
after shaping · CPC title
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