Method for manufacturing a porous film, porous film and method for tissue adhesion

Patent metadata

Field	Value
Publication number	US-11027040-B2
Application number	US-201715855694-A
Country	US
Kind code	B2
Filing date	Dec 27, 2017
Priority date	Dec 29, 2016
Publication date	Jun 8, 2021
Grant date	Jun 8, 2021

Abstract

The present disclosure provides a method for manufacturing a porous film, including: preparing a polymer mixture solution, wherein the polymer mixture solution includes polycaprolactone and at least one hydrophobic polymer; adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture; drying the solid mixture to form a film; and washing the film with a washing fluid to remove the solid particles from the film to form the porous film, wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is about 1:0.1-10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to the solid particles is about 1:0.01-250.

First claim

What is claimed is:

1. A method for manufacturing a non-fibrous porous film, comprising:
preparing a polymer mixture solution, wherein the polymer mixture solution comprises:
polycaprolactone (PCL); and
at least one hydrophobic polymer, which is selected from a group consisting of poly lactic acid (PLA), poly(lactic-co-glycolic acid (PLGA), poly(glycolic acid) (PGA), polyhydroxybutyrate (PHB), polydioxanone (PDS), poly(propylene fumarate) (PPF), polyanhydrides, polyacetals, poly(ortho esters), poly carbonates, polyurethanes, polyphosphazenes and polyphosphoester, wherein the molecular weight of the at least one hydrophobic polymer is about 10K-800K;
adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture, wherein the particle size of the solid particles is about 50-250 μm;
drying the solid mixture to form a film; and
washing the film with a washing fluid to remove the solid particles from the film to form a porous film,
wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is about 1:0.1 to 1:10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to solid particles is about 1:0.01 to 1:250, and
wherein the real density of the porous film is 1.5-5.0×10 3 g/cm 2 .

2. The method for manufacturing a porous film as claimed in claim 1 , wherein the porosity of the porous film is 80-99%, and the roughness of the porous film is 10-500 μm.

3. The method for manufacturing a porous film as claimed in claim 1 , wherein the thickness of the porous film is 10-1000 μm.

4. The method for manufacturing a porous film as claimed in claim 1 , wherein a method for preparing the polymer mixture solution comprises:
dissolving the polycaprolactone in a first solvent to form a first solution, and dissolving the at least one hydrophobic polymer in a second solvent to form a second solution, wherein the first solvent and the second solvent are the same or different; and
mixing the first solution with the second solution to form the polymer mixture solution.

5. The method for manufacturing a porous film as claimed in claim 4 , wherein the first solvent comprises dichloromethane, chloroform or acetone, and the second solvent comprises dichloromethane, chloroform or acetone.

6. The method for manufacturing a porous film as claimed in claim 1 , wherein a method for preparing the polymer mixture solution comprises:
dissolving the polycaprolactone and the at least one hydrophobic polymer in a solvent to form the polymer mixture solution.

7. The method for manufacturing a porous film as claimed in claim 6 , wherein the solvent comprises dichloromethane, chloroform or acetone.

8. The method for manufacturing a porous film as claimed in claim 1 , wherein the solid particles comprise chloride particles, oxide particles, hydroxide particles, fluoride particles, nitrate particles, sulfate particles, nitrite particles, ammonium salt, phosphate particles, silicate particles, carbonate particles or oxalate particles.

9. The method for manufacturing a porous film as claimed in claim 1 , wherein the solid particles are sodium chloride particles.

10. The method for manufacturing a porous film as claimed in claim 1 , wherein the at least one hydrophobic polymer is poly(lactic-co-glycolic acid).

11. The method for manufacturing a porous film as claimed in claim 10 , wherein the molecular weight of the poly(lactic-co-glycolic acid) is about 10K-240K.

12. The method for manufacturing a porous film as claimed in claim 1 , wherein the at least one hydrophobic polymer is poly(lactic-co-glycolic acid), and the solid particles are sodium chloride particles.

13. The method for manufacturing a porous film as claimed in claim 12 , wherein the molecular weight of the poly(lactic-co-glycolic acid) is about 10K-240K, and the particle size of the sodium chloride particles is about 50-250 μm.

14. The method for manufacturing a porous film as claimed in claim 12 , wherein a method for preparing the polymer mixture solution comprises:
dissolving the polycaprolactone in a first solvent to form a first solution, and dissolving the poly(lactic-co-glycolic acid) in a second solvent to form a second solution, wherein the first solvent and the second solvent are the same; and
mixing the first solution with the second solution to form the polymer mixture solution.

15. The method for manufacturing a porous film as claimed in claim 14 , wherein the weight ratio of the polycaprolactone to the poly(lactic-co-glycolic acid) is about 1:0.1 to 1:10, and the weight ratio of the polycaprolactone and the poly(lactic-co-glycolic acid) to the sodium chloride particles is about 1:0.01 to 1:200.

16. The method for manufacturing a porous film as claimed in claim 1 , wherein the washing fluid comprises water, hydrochloric acid, acetic acid, phosphoric acid or peroxy acid.

17. The method for manufacturing a porous film as claimed in claim 1 , wherein the polymer mixture solution further comprises at least one hydrophobic drug, wherein the weight ratio of the polycaprolactone, the at least one hydrophobic polymer and the at least one hydrophobic drug to solid particles is about 1:0.5 to 1:10.

18. The method for manufacturing a porous film as claimed in claim 17 , wherein the weight ratio of the polycaprolactone to the at least one hydrophobic drug is about 1:0.05 to 1:5.

19. The method for manufacturing a porous film as claimed in claim 17 , wherein the molecular weight of the at least one hydrophobic drug is about 50K-100K.

20. The method for manufacturing a porous film as claimed in claim 17 , wherein the at least one hydrophobic drug comprises citral, nitrogen mustard, cisplatin, paclitaxel or a combination thereof.

21. The method for manufacturing a porous film as claimed in claim 17 , wherein a method for preparing the polymer mixture solution comprises:
dissolving the polycaprolactone in a first solvent to form a first solution, and dissolving the at least one hydrophobic polymer and the at least one hydrophobic drug in a second solvent to form a second solution, wherein the first solvent and the second solvent are the same or different; and
mixing the first solution with the second solution to form the polymer mixture solution.

22. The method for manufacturing a porous film as claimed in claim 21 , wherein the first solvent comprises dichloromethane, chloroform or acetone, and the second solvent comprises dichloromethane, chloroform or acetone.

23. The method for manufacturing a porous film as claimed in claim 17 , wherein the at least one hydrophobic polymer is poly(lactic-co-glycolic acid), the at least one hydrophobic drug is citral, and the solid particles are sodium chloride particles.

Assignees

• Ind Tech Res Inst

Inventors

• Shen Hsin-Hsin
• Yang Ming-Chia
• Ho Chia-Chi
• Jang Fang-Jie
• Ou Che-Yu
• Liao Chi-Hsiang
• Hsu Brian
• Young Tai-Horng

Classifications

• A61L24/0036 Primary

  Porous materials, e.g. foams or sponges · CPC title

• A61L24/0089

  containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084 · CPC title

• A61L24/043

  Mixtures of macromolecular materials · CPC title

• A61L24/0042

  Materials resorbable by the body · CPC title

• A61L24/0015

  Medicaments; Biocides · CPC title