Methods and compositions for treating mesothelioma and small lung cancer that express midkine
US-10668078-B2 · Jun 2, 2020 · US
US11026950B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11026950-B2 |
| Application number | US-202016857285-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 24, 2020 |
| Priority date | Jul 28, 2016 |
| Publication date | Jun 8, 2021 |
| Grant date | Jun 8, 2021 |
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Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.
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What is claimed is: 1. A method of treating malignant mesothelioma, comprising the step of administering to an individual in need thereof, an effective amount of a pharmaceutical composition comprising a compound selected from or a pharmaceutically acceptable salt thereof, and a pharmaceutical carrier. 2. The method of claim 1 , wherein said compound is: or a pharmaceutically acceptable salt thereof. 3. The method of claim 1 , wherein the compound is administered with 4. The method of claim 1 , further comprising the step of administering to said individual a therapeutically effective amount of a BCL-2 inhibitor. 5. The method of claim 1 , wherein said individual is mammalian. 6. The method of claim 1 , wherein said individual is human. 7. The method of claim 4 , wherein said BCL-2 inhibitor is selected from ABT-737, ABT-199, GDC-0199, GX15-070 (Obatoclax), and combinations thereof.
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containing further heterocyclic ring systems · CPC title
the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine · CPC title
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