Methods, devices, and systems for blood flow

Patent metadata

Field	Value
Publication number	US-11026729-B2
Application number	US-202016837533-A
Country	US
Kind code	B2
Filing date	Apr 1, 2020
Priority date	May 6, 2016
Publication date	Jun 8, 2021
Grant date	Jun 8, 2021

Abstract

Various exemplary methods, systems, and devices for blood flow are provided. In general, an implant can be configured to be implanted in bone and to delay clotting of blood flowing from the bone. The implant can include an anti-coagulation agent to delay the clotting of the blood. The anti-coagulation agent can be a coating on the implant, can be natural to a material forming the implant, or can be impregnated into a material forming the implant. In an exemplary embodiment, the implant is implanted in a bone in a surgical procedure for securing a soft tissue to bone, such as a rotator cuff repair procedure or an anterior cruciate ligament (ACL) repair procedure.

First claim

What is claimed is:

1. A surgical device, comprising:
a biocompatible tubular member configured to be implanted in a bone of a patient, the tubular member having a solid sidewall defining an inner lumen extending through the tubular member such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen, and the tubular member having an anti-coagulation agent on the solid sidewall;
wherein the inner lumen has a bioabsorbable material disposed therein that occludes the inner lumen such that the blood cannot flow out of the inner lumen through the second open end of the inner lumen until the bioabsorbable material has been at least partially absorbed by the patient's body.

2. A surgical device, comprising:
a biocompatible tubular member configured to be implanted in a bone of a patient, the tubular member having a solid sidewall defining an inner lumen extending through the tubular member such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen, and the tubular member having an anti-coagulation agent on the solid sidewall;
wherein the inner lumen has a plug removably disposed therein that occludes the inner lumen such that the blood cannot flow out of the inner lumen through the second open end of the inner lumen until the plug is removed from the inner lumen, the plug being configured to be implanted in the patient with the tubular member; and
wherein the plug has a suture extending therefrom, the suture being configured to extend from inside the patient's body to outside the patient's body and to be pulled from outside the patient's body and thereby remove the plug from the inner lumen of the tubular member.

3. A surgical device, comprising:
a biocompatible tubular member configured to be implanted in a bone of a patient, the tubular member having a solid sidewall defining an inner lumen extending through the tubular member such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen, and the tubular member having an anti-coagulation agent on the solid sidewall;
wherein the inner lumen has a plug removably disposed therein that occludes the inner lumen such that the blood cannot flow out of the inner lumen through the second open end of the inner lumen until the plug is removed from the inner lumen, the plug being configured to be implanted in the patient with the tubular member; and
wherein the plug includes a knitted material that occludes the inner lumen until the knitted material is pulled to cause the knitted material to unravel.

4. A surgical device, comprising:
a biocompatible tubular member configured to be implanted in a bone of a patient, the tubular member having a solid sidewall defining an inner lumen extending through the tubular member such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen, and the tubular member having an anti-coagulation agent on the solid sidewall;
wherein the inner lumen has a plug removably disposed therein that occludes the inner lumen such that the blood cannot flow out of the inner lumen through the second open end of the inner lumen until the plug is removed from the inner lumen, the plug being configured to be implanted in the patient with the tubular member; and
wherein the plug is made from an energy activated material disposed therein that occludes the inner lumen until the energy activated material is activated by application of energy thereto.

5. The device of claim 1 , wherein the tubular member includes a retaining member configured to engage the bone in which the tubular member is implanted to retain the tubular member within the bone.

6. The device of claim 1 , wherein the anti-coagulation agent is coated on a surface of the solid sidewall.

7. The device of claim 1 , wherein the anti-coagulation agent is impregnated in a material forming the solid sidewall.

8. The device of claim 1 , wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor.

9. The device of claim 1 , wherein the tubular member is bioabsorbable.

10. The device of claim 1 , wherein the tubular member is not bioabsorbable.

11. The device of claim 1 , wherein the bioabsorbable material has a suture extending therefrom, the suture being configured to extend from inside the patient's body to outside the patient's body and to be pulled from outside the patient's body.

12. The device of claim 4 , wherein the tubular member includes a retaining member configured to engage the bone in which the tubular member is implanted to retain the tubular member within the bone.

13. The device of claim 4 , wherein the anti-coagulation agent is at least one of coated on a surface of the solid sidewall and impregnated in a material forming the solid sidewall.

14. The device of claim 4 , wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor.

15. The device of claim 2 , wherein the tubular member includes a retaining member configured to engage the bone in which the tubular member is implanted to retain the tubular member within the bone.

16. The device of claim 2 , wherein the anti-coagulation agent is at least one of coated on a surface of the solid sidewall and impregnated in a material forming the solid sidewall.

17. The device of claim 2 , wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor.

18. The device of claim 3 , wherein the tubular member includes a retaining member configured to engage the bone in which the tubular member is implanted to retain the tubular member within the bone.

19. The device of claim 3 , wherein the anti-coagulation agent is at least one of coated on a surface of the solid sidewall and impregnated in a material forming the solid sidewall.

20. The device of claim 3 , wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor,

Assignees

• Medos Int Sarl

Inventors

• Whittaker Gregory R
• Cleveland Benjamin
• Hwang Julia
• Spenciner David B
• Parrish William R
• Sengun Mehmet Z
• Theis Reagan A

Classifications

• A61L33/0011

  Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate · CPC title

• A61L31/16 Primary

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• A61B2017/00004

  (bio)absorbable, (bio)resorbable or resorptive · CPC title

• A61B17/0643

  with separate closing member, e.g. for interlocking with staple · CPC title

• A61B2017/045

  snug fit within the anchor · CPC title