Inert non-adsorbing crimpable capillaries and devices for adjusting gas flow in isotope ratio analysis

Patent metadata

Field	Value
Publication number	US-11024496-B2
Application number	US-201916290443-A
Country	US
Kind code	B2
Filing date	Mar 1, 2019
Priority date	Mar 1, 2018
Publication date	Jun 1, 2021
Grant date	Jun 1, 2021

Abstract

A gas transfer system for transferring gas into an analytical instrument for isotope ratio analysis comprises a capillary for delivering sample and/or reference gas from a gas source, a first connector for connecting the capillary to the gas source, a second connector for connecting the capillary to the analytical instrument, a crimping device, wherein the internal surface of the capillary comprises a coating material to prevent or minimize adsorption of water to the surface. Also provided is a device for regulating gas flow in a gas inlet system of an analytical instrument, comprising a body member having an internal gas flow channel, and a clamping member for attachment to the body member such that when the clamping member is tightened onto the body member, the internal gas flow channel is adjustably and reversibly crimped, to adjust gas flow therethrough.

First claim

What is claimed is:

1. A device for regulating gas flow in a gas inlet system of a mass spectrometer, comprising:
i. a body member having an internal gas flow channel with an inlet adapted to receive a capillary via a gas-tight connection and an outlet, for receiving and releasing gas respectively, the body member further being adapted to receive a clamping member in a location flanking the internal gas flow channel on a crimpable portion of a wall of the internal gas flow channel, the wall forming part of the body member and being defined between the gas flow channel and said location;
ii. a clamping member, for reversible attachment to the body member in said location, the clamping member comprising at least one crimping portion that is disposed so that, when the clamping member is attached to the body member, the crimping portion meets said crimpable portion of the wall of the internal gas flow channel,
and wherein the crimping portion is further adapted so that when the clamping member is attached to the body member and force is applied thereto, perpendicular to a longitudinal axis of the internal gas flow channel, the crimpable portion of the wall of the internal gas flow channel is forced inwardly, into the gas flow channel, at the point of contact between the crimping portion and the wall, thereby reducing gas flow through the internal gas flow channel, and wherein the clamping member comprises at least two holes for receiving threaded clamping screws, and wherein the body member comprises threaded receiving holes for receiving the clamping screws, so that when tightened the screws force the clamping member onto the body member, thereby generating force onto said crimpable portion of said wall, resulting in reduced gas flow through the internal flow channel.

2. The device of claim 1 , wherein the body member comprises at least one groove, for receiving the crimping portion of the clamping member, wherein the groove is adapted to render at least a portion of the body comprising the groove deformable by the clamping member, which portion comprises said point of contact of the crimpable portion of the wall defined between the gas flow channel and said location.

3. The device of claim 1 , wherein the crimping portion comprises at least a partially cylindrical structure that is disposed so that when attached to the body member, the at least partially cylindrical structure is approximately perpendicular to the internal flow channel.

4. The device of claim 1 , wherein the internal gas flow channel has an inner diameter in the range of about 100-800 μm, or in the range of about 200-600 μm, or in the range of about 300-500 μm.

5. The device of claim 1 , wherein the internal gas flow channel has a narrower section along a portion thereof.

6. The device of claim 5 , wherein the narrower section has an internal diameter that is in the range of about 100-500 μm, or in the range of about 100-400 μm, or about 300 μm.

7. The device of claim 5 , wherein the narrower section is located adjacent the crimpable portion of the wall of the internal gas flow channel whereby the crimping portion of the clamping member is adapted to crimp the internal gas flow channel within its narrower section.

8. The device of claim 1 , wherein the body member comprises an elongate body having an internal gas flow channel, the elongate body further comprising said groove and a receiving plate extending radially from the elongate body, flanking the groove, the receiving plate comprising threaded receiving holes for receiving the clamping screws, so that when the clamping member is mounted on the body member, the crimping portion sits in the groove and exerts force onto the gas flow channel through tightening of clamping screws.

9. The device of claim 1 , wherein the narrower section of the internal gas flow channel has a narrower internal diameter than the external diameter of the capillary.

10. The device of claim 1 , wherein the inlet has a connected capillary which is not crimpable and which comprises at least on its internal surface a material that prevents adsorption of water to the surface.

11. The device of claim 10 , wherein the capillary comprises at least one material selected from silica, ceramic and glass.

12. The device of claim 1 , wherein the device is made from metal or metal alloy, or stainless steel.

13. The device of claim 1 , wherein the internal gas flow channel comprises a coating comprising a material that prevents adsorption of water to the internal surface of the channel.

Assignees

• Thermo Fisher Scient Bremen Gmbh

Inventors

• Krummen Michael
• Radke Jens
• Schwieters Johannes
• STOEBENER Nils
• Seedorf Ronald

Classifications

• H01J49/0422

  for gaseous samples (interfaces to gas chromatographs G01N30/7206) · CPC title

• H01J49/0404 Primary

  Capillaries used for transferring samples or ions (electrospray nozzles H01J49/167) · CPC title

• G01N27/62

  by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• G01N30/7206 Primary

  interfaced to gas chromatograph (interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04) · CPC title