Absorbable iron-based alloy medical device implant

Patent metadata

Field	Value
Publication number	US-11020514-B2
Application number	US-201616068124-A
Country	US
Kind code	B2
Filing date	Jun 27, 2016
Priority date	Nov 27, 2015
Publication date	Jun 1, 2021
Grant date	Jun 1, 2021

Abstract

An absorbable iron-based alloy medical device implant, comprising an iron-based alloy substrate (11) and a degradable polymer (13) provided on a surface of an iron-based alloy substrate (11), and a zinc-containing protective member (12) provided on the surface of the iron-based alloy substrate (11). The zinc-containing protective member (12) is either a zinc compound or a mixture comprising the zinc compound and at least one of a phosphate-containing compound, a degradable binder, or a water-soluble binder. The weight ratio of the zinc compound in the mixture is ≥20% and <100%. The zinc-containing protective member (12) can delay corrosion of the iron-based alloy substrate (11) during an early stage of medical device implantation. The iron-based alloy substrate (11) is essentially corrosion-free during the early stage of medical device implantation, and is therefore able to satisfy clinical requirements of mechanical performance during the early stage of medical device implantation.

First claim

The invention claimed is:

1. An absorbable iron-based alloy medical device implant, comprising an iron-based alloy substrate and a degradable polymer disposed on the surface of the iron-based alloy substrate, wherein the absorbable iron-based alloy medical device implant further comprises a zinc-containing protector disposed on the surface of the iron-based alloy substrate, wherein the zinc protector comprises a zinc sulfate-cyclodextrin coating.

2. An absorbable iron-based alloy medical device implant, comprising an iron-based alloy substrate and a degradable polymer disposed on the surface of the iron-based alloy substrate, wherein the absorbable iron-based alloy medical device implant further comprises a zinc-containing protector disposed on the surface of the iron-based alloy substrate, wherein the zinc protector comprises a zinc chloride-polyethylene glycol coating.

3. An absorbable iron-based alloy medical device implant, comprising an iron-based alloy substrate and a degradable polymer disposed on the surface of the iron-based alloy substrate, wherein the absorbable iron-based alloy medical device implant further comprises a zinc-containing protector disposed on the surface of the iron-based alloy substrate, the zinc-containing protector comprises a zinc phosphate-polyethylene glycol coating layer.

4. The absorbable iron-based alloy medical device implant according to claim 3 , wherein the zinc-containing protector covers the surface of the iron-based alloy substrate, and the degradable polymer covers at least part of the surface of the zinc-containing protector.

5. The absorbable iron-based alloy medical device implant according to claim 3 , wherein the degradable polymer covers at least part of the surface of the zinc-containing protector, or the zinc-containing protector and the degradable polymer cover different regions of the surface of the iron-based alloy substrate in a staggered manner, or the degradable polymer covers at least part of the surface of the zinc-containing protector, and also covers at least part of a non-covered region.

6. The absorbable iron-based alloy medical device implant according to claim 3 , wherein the zinc-containing protector is in direct contact with the surface of the iron-based alloy substrate.

7. The absorbable iron-based alloy medical device implant according to claim 3 , wherein the zinc-containing protector is embedded into the iron-based alloy substrate.

8. The absorbable iron-based alloy medical device implant according to claim 3 , wherein the iron-based alloy substrate is pure iron or an iron-based alloy with a carbon content less than or equal to 2.11 weight percentage.

9. The absorbable iron-based alloy medical device implant according to claim 3 , wherein an active drug is mixed in the degradable polymer.

Assignees

• Lifetech Scient Shenzhen Co
• Biotyx Medical Shenzhen Co Ltd

Inventors

• Qi Haiping
• Lin Wenjiao

Classifications

• A61L27/04 Primary

  Metals or alloys · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• A61L27/12

  Phosphorus-containing materials, e.g. apatite · CPC title

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title

• A61L31/022 Primary

  Metals or alloys · CPC title