Method and system to detect R-waves in cardiac arrhythmic patterns

Patent metadata

Field	Value
Publication number	US-11020036-B2
Application number	US-201815973351-A
Country	US
Kind code	B2
Filing date	May 7, 2018
Priority date	May 7, 2018
Publication date	Jun 1, 2021
Grant date	Jun 1, 2021

Abstract

Computer implemented methods and systems for detecting arrhythmias in cardiac activity are provided. The method is under control of one or more processors configured with specific executable instructions. The method obtains a far field cardiac activity (CA) data set that includes far field CA signals for beats. The method applies a feature enhancement function to the CA signals to form an enhanced feature in the CA data set. The method calculates an adaptive sensitivity level and sensitivity limit based on the enhanced feature from one or more beats within the CA data set and automatically iteratively analyzes a beat segment of interest by comparing the beat segment of interest to the current sensitivity level to determine whether one or more R-waves are present within the beat segment of interest. The method repeats the iterative analyzing operation while progressively adjusting the current sensitivity level until i) the one or more R-waves are detected in the beat segment of interest and/or ii) the current sensitivity level reaches the sensitivity limit. The method detects an arrhythmia within the beat segment of interest based on a presence or absence of the one or more R-waves and records results of the detecting of the arrhythmia.

First claim

What is claimed is:

1. A system for detecting arrhythmias in cardiac activity, comprising:
memory to store specific executable instructions;
one or more processors configured to execute the specific executable instructions for:
obtaining a far field cardiac activity (CA) data set that includes far field CA signals for beats;
calculating an adaptive sensitivity level based on;
automatically iteratively analyzing a beat segment of interest by:
comparing the beat segment of interest to a current adaptive sensitivity level to determine whether one or more R-waves are present within the beat segment of interest;
repeating the iterative analyzing operation while progressively adjusting the current adaptive sensitivity level until i) the one or more R-waves are detected in the beat segment of interest and/or ii) the current adaptive sensitivity level reaches a sensitivity limit; and

detecting an arrhythmia within the beat segment of interest based on a presence or absence of the one or more R-waves, wherein the processor is further configured to confirm or deny a bradycardia episode, as the arrhythmia, based on a number of X beats within a bradycardia zone out of a total of Y beats within the CA data set; and
recording results of the detecting of the arrhythmia.

2. The system of claim 1 , wherein the applying, calculating and automatically iteratively analyzing operations are performed as a second pass confirmation for an arrhythmia episode declared by a first pass arrhythmia detection algorithm implemented by an implantable device.

3. The system of claim 2 , wherein the CA data set includes device documented markers in combination with the CA signals, the CA data set generated by the implantable device in connection with the first pass arrhythmia detection algorithm, the first pass arrhythmia detection algorithm declaring the arrhythmia episode to be one of a bradycardia, tachycardia, asystole or atrial fibrillation episode.

4. The system of claim 1 , wherein the processor is configured to calculate the current adaptive sensitivity level by determining amplitudes for one or more features of the beat segment of interest, the sensitivity limit based on the amplitudes; and wherein the comparing operation includes determining whether at least a portion of the beat segment of interest exceed the current adaptive sensitivity level.

5. The system of claim 3 , wherein the processor is configured to determine the current adaptive sensitivity level based on a comparison of an ensemble R-wave peak, ensemble T-wave peak and ensemble P-wave peak amplitudes and/or variability that represent amplitudes and/or variability for the one or more R-waves.

6. The system of claim 1 , wherein the processor is configured to analyze the beat segment of interest iteratively while adjusting the current adaptive sensitivity level to increase resolution during each iterative analysis until reaching the sensitivity limit or specific exiting criteria.

7. A system for detecting arrhythmias in cardiac activity, comprising:
memory to store specific executable instructions;
one or more processors configured to execute the specific executable instructions for:
obtaining a far field cardiac activity (CA) data set that includes far field CA signals for beats;
calculating an adaptive sensitivity level based on;
automatically iteratively analyzing a beat segment of interest by:
comparing the beat segment of interest to a current adaptive sensitivity level to determine whether one or more R-waves are present within the beat segment of interest;
repeating the iterative analyzing operation while progressively adjusting the current adaptive sensitivity level until i) the one or more R-waves are detected in the beat segment of interest and/or ii) the current adaptive sensitivity level reaches a sensitivity limit; and

detecting an arrhythmia within the beat segment of interest based on a presence or absence of the one or more R-waves, wherein the processor is further configured to confirm or deny an asystole episode, as the arrhythmia, when the beat segment of interest exhibits no detected electrical activity for a period of time that exceeds an asystole threshold; and
recording results of the detecting of the arrhythmia.

8. The system of claim 1 , wherein the processor is configured to apply a feature enhancement function to the CA signals to enhance at least one of an R-wave feature, T-wave feature, P-wave feature and/or suppresses noise to form an enhanced feature in the CA data set; and to calculate the adaptive sensitivity level and sensitivity limit based on the enhanced feature from one or more beats within the CA data set.

9. The system of claim 8 , wherein the processor is configured to apply a normalization function and a non-linear scaling function to the CA signals as the feature enhancement function.

10. A system for detecting arrhythmias in cardiac activity, comprising:
memory to store specific executable instructions;
one or more processors configured to execute the specific executable instructions for:
obtaining a far field cardiac activity (CA) data set that includes far field CA signals for beats;
identifying a T-wave characteristic of interest (COI) and an R-wave COI from the CA signals;
adjusting profile parameters of a sensitivity profile based on the T-wave COI and R-wave COI, the sensitivity profile defining a time-varying sensitivity level and a sensitivity limit;
automatically iteratively analyzing a beat segment of interest by:
comparing the beat segment of interest to the time-varying sensitivity level to determine whether an R-wave is detected within the beat segment of interest; and

detecting an arrhythmia within the beat segment of interest based on a presence or absence of the R-wave; and
recording results of the detecting of the arrhythmia.

11. The system of claim 10 , wherein the processor is configured to perform the identifying and adjusting operations on a beat by beat basis.

12. The system of claim 10 , wherein the processor is further configured to identify, in connection with the R-wave COI, a rise rate of a current beat and determining whether the rise rate of the current beat exceeds a rise rate of a preceding beat by more than a R-wave rise rate threshold.

13. The system of claim 10 , wherein the processor is further configured to adjust at least one of a start sensitivity parameter that defines a start sensitivity of the sensitivity profile.

14. The system of claim 10 , wherein the processor is further configured to identify, in connection with the T-wave COI and R-wave COI, at least one of a rapid rise characteristic, a rapid heart rate characteristic, T/R-wave ratio characteristic or a T-wave-to-refractory proximity characteristic.

15. The system of claim 10 , wherein the processor is further configured to adjust, based on the T-wave COI and R-wave COI, at least one of a refractory period duration, start sensitivity, decay rate, or sensitivity limit parameter, the start sensitivity parameter defining a start sensitivity of the sensitivity profile, the refractory period duration parameter defining a blanking interval, a decay rate parameter defining a slope of a linear time-varying sensitivity level decline, the sensitivity limit parameter defining a lowest sensitivity level that linear sensitivity level decline is not allowed to go below.

16. A system for detecting arrhythmias in cardiac activity, comprising:
memory to store specific executable instructions;
one or more processors configured to execute the specific executable instructions for:
obtaining a far field car

Assignees

• Pacesetter Inc

Inventors

• Dawoud Fady
• Qu Fujian
• Rosenberg Stuart
• Bornzin Gene A
• Gill Jong
• Malhotra Neha
• Min Xiaoyi

Classifications

• A61B5/29

  for permanent or long-term implantation · CPC title

• A61B5/352 Primary

  Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval · CPC title

• A61N1/3702

  Physiological parameters (A61N1/365 takes precedence; evoked response A61N1/371) · CPC title

• A61B5/7203

  for noise prevention, reduction or removal · CPC title

• A61N1/3704

  Circuits specially adapted therefor, e.g. for sensitivity control · CPC title