Photoacoustic imaging diagnosis apparatus and method of controlling the same

Patent metadata

Field	Value
Publication number	US-11020007-B2
Application number	US-201715696933-A
Country	US
Kind code	B2
Filing date	Sep 6, 2017
Priority date	Dec 26, 2016
Publication date	Jun 1, 2021
Grant date	Jun 1, 2021

Abstract

A method of controlling a photoacoustic imaging diagnosis apparatus includes irradiating to an object an optical signal having a wavelength corresponding to an optical energy absorption wavelength of a contrast medium that is injected to the object; receiving a photoacoustic signal generated from the object in response to the optical signal; generating scan information representing an intensity of the photoacoustic signal based on the photoacoustic signal; determining a damage degree of the object by using a variation in the intensity of the photoacoustic signal during a preset time period included in the scan information; and displaying the damage degree of the object.

First claim

What is claimed is:

1. A method of controlling a photoacoustic imaging diagnosis apparatus, the method comprising:
irradiating, to a liver of an object, an optical signal having a wavelength corresponding to an optical energy absorption wavelength of a contrast medium that is injected to the object
receiving a photoacoustic signal generated from the liver in response to the optical signal;
generating scan information representing an intensity of the photoacoustic signal based on the photoacoustic signal;
determining a damage degree of the liver based on an amount by which the intensity of the photoacoustic signal is reduced during a predetermined time using the scan information;
identifying an excision target region of the liver from among a plurality of regions classified according to the damage degree;
determining a location for an excision procedure corresponding to the excision target region; and
displaying the damage degree of the liver and the location for the excision procedure of the liver,
wherein the determining of the damage degree of the liver comprises determining a reserve function of the liver based on a ratio between a first intensity of the photoacoustic signal at a first time point of administering the contrast medium and a second intensity of the photoacoustic signal at a second time point that is the predetermined time after the first time point, and
wherein the determining the location for the excision procedure comprises determining the location of the excision procedure corresponding to the reserve function of the liver.

2. The method of claim 1 , wherein the scan information comprises information about the intensity of the photoacoustic signal with respect to each of a plurality of regions of the liver,
the determining of the damage degree of the liver comprises generating a respective damage value of each of the plurality of regions by digitizing a respective damage degree in each of the plurality of regions, and
the displaying of the damage degree of the liver and the location for the excision procedure of the liver further comprises:
generating a photoacoustic image corresponding to the liver by using the photoacoustic signal;
color-coding the photoacoustic image in colors corresponding to the respective damage values of the plurality of regions; and
displaying the color-coded photoacoustic image.

3. A non-transitory computer-readable recording medium having embodied thereon a program for executing the method of controlling the photoacoustic imaging diagnosis apparatus according to claim 1 .

4. The method of claim 1 , wherein the displaying of the damage degree of the liver and the location for the excision procedure of the liver further comprises:
generating a photoacoustic image by using the photoacoustic signal and a time intensity curve (TIC) representing a variation in the intensity of the photoacoustic signal according to time, based on the scan information; and
displaying the TIC and the photoacoustic image.

5. The method of claim 4 , further comprising:
receiving an input for setting a region of interest; and
setting the region of interest in the photoacoustic image, based on the input,
wherein the scan information comprises information representing the intensity of the photoacoustic signal transmitted from the region of interest, and the TIC is about the photoacoustic signal transmitted from the region of interest.

6. The method of claim 1 , wherein the identifying of the excision target region of the liver comprises:
generating a damage value by digitizing the damage degree of the liver; and
identifying the excision target region of the liver according to the damage value.

7. The method of claim 6 , further comprising
storing excision target regions corresponding to preset values, and
the identifying of the excision target region of the liver comprises identifying the excision target region corresponding to the damage value by comparing the damage value with the preset values.

8. The method of claim 6 , wherein the scan information comprises information about the intensity of the photoacoustic signal with respect to each of a plurality of regions of the liver,
the generating of the damage value comprises generating a damage value for each of the plurality of regions by digitizing a damage degree in each of the plurality of regions, and
the determining of the excision target region of the liver comprises determining at least one of the plurality of regions as the excision target region by using the damage value of each of the plurality of regions.

9. A photoacoustic imaging diagnosis apparatus comprising:
an optical signal transmitter configured to irradiate, to a liver of an object, an optical signal having a wavelength corresponding to an optical energy absorption wavelength of a contrast medium that is injected to the object;
an ultrasound probe configured to receive a photoacoustic signal generated from the liver in response to the optical signal;
at least one processor configured to generate scan information representing an intensity of the photoacoustic signal based on the photoacoustic signal, determine a damage degree of the liver based on an amount by which the intensity of the photoacoustic signal is reduced during a predetermined time using the scan information, identify an excision target region of the liver from among a plurality of regions classified according to the damage degree, and determine a location for an excision procedure corresponding to the excision target region; and
a display configured to display the damage degree of the liver and the location for the excision procedure of the liver,
wherein the at least one processor is configured to,
determine a reserve function of the liver based on a ratio between a first intensity of the photoacoustic signal at a first time point of administering the contrast medium and a second intensity of the photoacoustic signal at a second time point that is a predetermined time after the first time point, and
identify the excision target region of the liver from among a plurality of regions classified according to the damage degree, and determine the location for the excision procedure corresponding to the excision target region based on the reserve function of the liver,
wherein the display is configured to display the location for the excision procedure of the liver.

10. The photoacoustic imaging diagnosis apparatus of claim 9 , wherein the at least one processor generates the scan information comprising information about the intensity of a photoacoustic signal with respect to each of a plurality of regions of the liver, generates a respective damage value for each of the plurality of regions by digitizing a respective damage degree in each of the plurality of regions based on the scan information, generates a photoacoustic image corresponding to the liver by using the photoacoustic signal, color-codes the photoacoustic image in preset colors corresponding to the respective damage values of the plurality of regions, and the display displays the color-coded photoacoustic image.

11. The photoacoustic imaging diagnosis apparatus of claim 9 , wherein the at least one processor generates a photoacoustic image based on the photoacoustic signal and a time intensity curve (TIC) representing a variation in the intensity of the photoacoustic signal according to time, based on the scan information, and the display displays the TIC and the photoacoustic image.

12. The photoacoustic imaging diagnosis apparatus of claim 11 , further comprising an input interface configured to receive an input for setting a region of interest, and
wherein the at least one

Assignees

• Samsung Medison Co Ltd

Inventors

• Kim Beom-Gyu
• Jung Jin-Woo
• Lee Jae-Ho
• Choi Deok-Woo
• Lee Won-Jae
• Lim Hyo-Keun

Classifications

• A61B8/481 Primary

  involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream · CPC title

• A61B5/0095 Primary

  by applying light and detecting acoustic waves, i.e. photoacoustic measurements · CPC title

• A61B8/5207

  involving processing of raw data to produce diagnostic data, e.g. for generating an image · CPC title

• A61B5/4244

  liver · CPC title

• A61B5/743

  Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots · CPC title