Method for determining a characteristic blood value, computed tomography device, computer program and electronically readable storage medium

Patent metadata

Field	Value
Publication number	US-11017529-B2
Application number	US-201916386455-A
Country	US
Kind code	B2
Filing date	Apr 17, 2019
Priority date	Apr 20, 2018
Publication date	May 25, 2021
Grant date	May 25, 2021

Abstract

A method is for determining at least one first characteristic value of blood in a patient. In an embodiment, the method includes acquiring, via a computed tomography device, computed tomography data of the patient for at least two energy levels of radiation using multi-energy computed tomography; defining a region of interest including blood, in at least one image data set reconstructed from the computed tomography data acquired; determining, at least in the region of interest defined, attenuation coefficients for each energy level of the at least two energy levels; performing material decomposition into at least two materials, one material of the two materials being iron, using the attenuation coefficients determined, yielding at least a fraction of iron in the region of interest defined; and determining the at least one first characteristic value, at least one of as and from the fraction of iron yielded.

First claim

What is claimed is:

1. A method for determining at least one first characteristic value of blood in a patient, the at least one first characteristic value describing iron content of the blood, the method comprising:
acquiring, via a computed tomography device, computer tomography data of the patient for at least two energy levels of radiation using multi-energy computed tomography;
defining a region of interest in at least one image data set reconstructed from the acquired computed tomography data, the region of interest including the blood;
performing material decomposition into at least two materials using the determined attenuation coefficients to obtain at least a fraction of iron in the blood of the defined region of interest, one material of the at least two materials being iron; and
determining the at least one first characteristic value based on the fraction of iron.

2. The method of claim 1 , wherein the defining the region of interest defines the region of interest at least one of at least partly manually and at least partly automatically.

3. The method of claim 1 , wherein the defining the region of interest defines the region of interest as a part of a blood vessel.

4. The method of claim 1 , wherein the at least two materials includes both blood plasma and erythrocytes.

5. The method of claim 1 , wherein the at least two materials include three materials and the performing the material decomposition includes,
performing a three material decomposition, another of the at least two materials includes blood plasma and erythrocytes.

6. The method of claim 5 , further comprising:
determining at least one second characteristic value of blood from at least one of a fraction of blood plasma obtained from the three material decomposition and a fraction of erythrocytes obtained from the three material decomposition.

7. The method of claim 6 , wherein one of the at least one second characteristic value is a haematocrit value.

8. The method of claim 6 , wherein the blood plasma and the erythrocytes are assigned a comparable spectral behaviour and the performing a three material decomposition includes,
calculating the fraction of blood plasma and the fraction of erythrocytes in a space spanned by attenuation values at the at least two energy levels by projecting a measured point along an iron direction onto a line connecting a pure blood plasma point and a pure erythrocytes point and determining the fraction of blood plasma and the fraction of erythrocytes according to the projected measured point, the projected measured point dividing the line.

9. The method of claim 1 , wherein one of the at least one first characteristic value is a mean corpuscular haemoglobin value.

10. The method of claim 1 , wherein the determining determines the at least one first characteristic value in at least two measurements separated in time and determines a trend information.

11. The method of claim 1 , wherein the acquiring includes using a photon counting detector to acquire the computed tomography data.

12. A computed tomography device, comprising:
at least one acquisition arrangement including an x-ray source and an x-ray detector; and
a control device, configured to determine at least one first characteristic value of blood in a patient, the at least one first characteristic value describing iron content of the blood, by at least:
acquiring, via a computed tomography device, computed tomography data of the patient for at least two energy levels of radiation using multi-energy computed tomography;
defining a region of interest, in at least one image data set reconstructed from the acquired computed tomography data, the region of interest including the blood,
determining attenuation coefficients for each energy level of the at least two energy levels in at least the defined region of interest,
performing material decomposition into at least two materials using the determined attenuation coefficients to obtain at least a fraction of iron in the blood of the defined region of interest, one material of the at least two materials being iron, and
determining the at least one first characteristic value based on the fraction of iron.

13. A non-transitory computer readable medium storing a computer program which, when the computer program is executed in a control device of a computed tomography device, is configured to perform the method of claim 1 .

14. A non-transitory electronically readable storage medium, storing a computer program which, when the computer program is executed in a control device of a computed tomography device, is configured to perform the method of claim 1 .

15. The method of claim 2 , wherein the defining the region of interest defines the region of interest using a segmentation algorithm.

16. The method of claim 3 , wherein the defining the region of interest defines the region of interest as a part of an aorta.

17. The method of claim 4 , wherein the acquiring includes using a photon counting detector to acquire the computed tomography data.

18. The method of claim 5 , wherein the acquiring includes using a photon counting detector to acquire the computed tomography data.

19. The computed tomography device of claim 12 , wherein the x-ray detector is a photon counting detector.

Assignees

• Siemens Healthcare Gmbh

Inventors

• Yan Jing
• Flohr Thomas
• Schmidt Bernhard

Classifications

• A61B6/032 Primary

  Transmission computed tomography [CT] · CPC title

• G06T7/0012 Primary

  Biomedical image inspection · CPC title

• G06T12/30

  Image post-processing, e.g. metal artefact correction · CPC title

• G06V20/695

  Preprocessing, e.g. image segmentation · CPC title

• G06T2207/10116

  X-ray image · CPC title