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US-2024102202-A1 · Mar 28, 2024 · US
Synthetic single domain antibody
US11014977B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11014977-B2 |
| Application number | US-201816016738-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 25, 2018 |
| Priority date | Nov 4, 2013 |
| Publication date | May 25, 2021 |
| Grant date | May 25, 2021 |
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- Title
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Abstract
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The invention relates to the identification of a highly stable single domain antibody scaffold (hs2dAb) and its use in generating synthetic single domain antibody library (hs2dAb-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
First claim
Opening claim text (preview).
The invention claimed is: 1. An isolated nucleic acid that encodes an antigen-binding protein comprising a synthetic single domain antibody of the following formula: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4, said nucleic acid comprises nucleic acid sequences encoding framework regions FR1, FR2, FR3 and FR4 having at least 90% identity to SEQ ID NOs 5-8 respectively. 2. The isolated nucleic acid of claim 1 , wherein the framework regions of said synthetic single domain antibody consist of FR1 of SEQ ID NO:1, FR2 of SEQ ID NO:2, FR3 of SEQ ID NO: 3 and FR4 of SEQ ID NO:4, with at least 1, 2 or 3 conservative amino acid substitutions in at least one of FR1, FR2, FR3 and FR4. 3. A recombinant host cell for the production of an antigen-binding protein comprising a synthetic single domain antibody of the following formula: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4, said host cell comprising the nucleic acid of claim 1 . 4. A process for the production of an antigen-binding protein, comprising culturing the host cell of claim 3 under appropriate conditions for the production of the antigen-binding protein, and isolating said protein.
Assignees
Inventors
Classifications
Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody® · CPC title
Libraries containing peptides or polypeptides, or derivatives thereof · CPC title
against translation products of oncogenes · CPC title
against material not provided for elsewhere {, e.g. haptens, metals, DNA, RNA, amino acids} · CPC title
Complementarity determining region [CDR] · CPC title
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- What does patent US11014977B2 cover?
- The invention relates to the identification of a highly stable single domain antibody scaffold (hs2dAb) and its use in generating synthetic single domain antibody library (hs2dAb-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
- Who is the assignee on this patent?
- Inst Nat Sante Rech Med, Inst Curie, Univ Toulouse 3 Paul Sabatier, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/005. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 25 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).