Compositions and methods for the treatment of inflammation and pain
US-10343994-B2 · Jul 9, 2019 · US
Method for preparing donepezil pamoate
US11014885B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11014885-B2 |
| Application number | US-201816618896-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 5, 2018 |
| Priority date | Jun 5, 2017 |
| Publication date | May 25, 2021 |
| Grant date | May 25, 2021 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Disclosed is a new method for preparing a donepezil pamoate (1-benzyl-4-[(5,6-dimethoxyindan-2-one)methyl]piperidine pamoate). The donepezil pamoate prepared by using the method has a high purity and a good flowability.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for preparing a crystal form A of a compound of formula I, comprising dissolving the compound of formula I in a reaction solvent and adding another solvent dropwise for precipitation to give the crystal form A of the compound of formula I, wherein the reaction solvent is acetone, and wherein another solvent is water. 2. The method according to claim 1 , wherein dissolving is carried out at a temperature of from 0 to 50° C. 3. The method according to claim 1 , wherein dissolving is carried out at a temperature of from 15 to 30° C. 4. The method according to claim 1 , wherein adding another solvent dropwise is carried out at a temperature of 0 to 50° C. 5. The method according to claim 1 , wherein adding another solvent dropwise is carried out at a temperature of 15 to 30° C.
Assignees
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Classifications
- C07C65/11Primary
with carboxyl groups on a condensed ring system containing two rings · CPC title
Crystalline forms, e.g. polymorphs · CPC title
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title
by change of the physical state, e.g. crystallisation · CPC title
- C07D211/32Primary
by oxygen atoms · CPC title
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Frequently asked questions
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- What does patent US11014885B2 cover?
- Disclosed is a new method for preparing a donepezil pamoate (1-benzyl-4-[(5,6-dimethoxyindan-2-one)methyl]piperidine pamoate). The donepezil pamoate prepared by using the method has a high purity and a good flowability.
- Who is the assignee on this patent?
- Zhejiang Huahai Pharm Co Ltd, Shanghai Aobo Pharmtech Inc Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07C65/11. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 25 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).