Scaffold for alloprosthetic composite implant

Patent metadata

Field	Value
Publication number	US-11013602-B2
Application number	US-201715635373-A
Country	US
Kind code	B2
Filing date	Jun 28, 2017
Priority date	Jul 8, 2016
Publication date	May 25, 2021
Grant date	May 25, 2021

Abstract

An alloprosthetic composite implant comprising includes a structural porous scaffold having a pore density profile corresponding to a density profile of bone to be replaced. A plurality of cells are seeded within pores of the porous scaffold and grown by incubation. The cells may include osteoblasts and/or stem cells to form the structure of the implant, and one or more cartilage layers may be grown on top of the scaffold. The pore density profile of the scaffold may be formed based on one or both of the bone density profile of the bone to be removed, and the bone density profile of the native bone that will be in contact with the alloprosthetic implant. A robot may be employed reo resect the native bone and also to shape the alloprosthetic implant to fit into place in the native bone.

First claim

The invention claimed is:

1. A method of implanting an alloprosthetic composite implant including an implant scaffold, the method comprising:
determining a bone density profile of a bone of a patient to be contacted by the scaffold;
forming the scaffold to have a pore density profile, wherein the pore density profile of the scaffold is formed based on the determined bone density profile of the bone of the patient;
seeding a plurality of viable cells into the scaffold;
incubating the scaffold including the plurality of viable cells to grow bone throughout the scaffold;
after growing the bone throughout the scaffold, growing at least one layer of cartilage on top of the grown bone to produce the alloprosthetic composite implant having a first shape;
robotically resecting native bone of a patient to have a particular geometry; and
after growing the at least one layer of cartilage on top of the grown bone, fixing the alloprosthetic composite implant having the first shape to a stand, and intraoperatively robotically machining the alloprosthetic composite implant from the first shape into a second shape corresponding to the particular geometry while the alloprosthetic composite implant is fixed to the stand, the second shape being different than the first shape; and
implanting the alloprosthetic composite implant having the second shape into patient adjacent the resected native bone of the patient,
wherein a portion of the scaffold intended to contact the native bone is formed with a pore density profile based on the determined bone density profile of the bone of the patient to be contacted by the scaffold.

2. The method of claim 1 , wherein the step of forming the scaffold is performed by additive manufacturing.

3. The method of claim 2 , wherein the additive manufacturing is 3-D printing.

4. The method of claim 1 , wherein the step of robotically resecting native bone of the patient includes forming a first interlocking shape in the native bone and the step of robotically machining the alloprosthetic composite implant includes forming a second interlocking shape in the alloprosthetic composite implant having a complementary shape to the first interlocking shape.

5. The method of claim 1 , wherein the formed scaffold includes an inner portion adapted to contact native bone of the patient, and an outer portion opposite the inner portion, a scaffold density of the outer portion being greater than a scaffold density of the inner portion.

6. The method of claim 5 , wherein the outer portion of the scaffold is formed with a lower pore density than the inner portion of the scaffold.

7. The method of claim 6 , wherein the pore density of the outer portion of the scaffold is based on a density of a cortical section of the bone of the patient.

8. The method of claim 6 , wherein the pore density of the inner portion of the scaffold is based on a density of a cancellous section of the bone of the patient.

9. The method of claim 1 , wherein the scaffold is formed from metal.

10. The method of claim 9 , wherein the metal is titanium.

11. The method of claim 1 , wherein the scaffold is formed of a bioabsorbable material.

12. The method of claim 1 , wherein seeding the plurality of viable cells into the scaffold includes seeding osteoblasts into the scaffold.

13. The method of claim 1 , wherein seeding the plurality of viable cells into the scaffold includes seeding pluripotent cells into the scaffold.

14. The method of claim 1 , wherein growing the at least one layer of cartilage on top of the grown bone includes forming a first inner layer of cartilage on the scaffold prior to robotically machining the alloprosthetic composite implant.

15. The method of claim 14 , further wherein growing the at least one layer of cartilage on top of the grown bone includes forming a second layer of cartilage on the first layer of cartilage prior to robotically machining the alloprosthetic composite implant.

16. The method of claim 1 , wherein incubating the scaffold includes incubating the scaffold in a nutrient rich medium.

17. The method of claim 1 , wherein the scaffold is formed of collagen.

Assignees

• Mako Surgical Corp

Inventors

• Bonutti Peter M

Classifications

• A61F2002/30971

  Laminates, i.e. layered products · CPC title

• A61F2310/00359

  Bone or bony tissue · CPC title

• A61F2002/30929

  having at least two superposed coatings · CPC title

• A61F2002/3092

  having an open-celled or open-pored structure · CPC title

• A61F2/28 Primary

  Bones · CPC title