Water dispersible formulations

Patent metadata

Field	Value
Publication number	US-11013245-B2
Application number	US-201816485651-A
Country	US
Kind code	B2
Filing date	Feb 9, 2018
Priority date	Feb 14, 2017
Publication date	May 25, 2021
Grant date	May 25, 2021

Abstract

The present invention relates to water dispersible formulations of 3-nitrooxypropanol and derivatives thereof as well as to the production of such formulations.

First claim

The invention claimed is:

1. A water dispersible powderous formulation comprising:
(i) at least 0.1 weight-% (wt-%), based on the total weight of the powderous formulation, of a compound of formula (I):

wherein
n is an integer from 1 to 15,
R 1 is H, C 1 -C 6 alkyl, phenyl, —OH, —NH 2 , —CN, —COOH, —O(C═O)R 8 , —NHC(═O)R 8 , SO 2 NHR 8 or —ONO 2 , and
R 8 is C 1 -C 6 alkyl, phenyl or pyridyl, with the proviso that when n is >3 the hydrocarbon chain may be interrupted by —O or NH,

(ii) 0 to 40 wt-%, based on the total weight of the powderous formulation, of an edible oil, and
(iii) at least 25 wt-%, based on the total weight of the powderous formulation, of precipitated silica.

2. The water dispersible powderous formulation according to claim 1 further comprising:
(iv) 0 to 10 wt-%, based on the total weight of the powderous formulation, of water and/or an additive.

3. The water dispersible powderous formulation according to claim 2 , wherein the additive comprises at least one thickener selected from the group consisting of gums and cellulose derivatives.

4. The water dispersible powderous formulation according to claim 3 , wherein the at least one thickener is selected from the group consisting of xanthan gum, karaya gum and ethylcellulose.

5. The water dispersible powderous formulation according to claim 1 consisting of:
(i) 2 to 20 wt-%, based on the total weight of the powderous formulation, of the compound of formula (I),
(ii) 10 wt-% to 45 wt-%, based on the total weight of the powderous formulation, of the edible oil,
(iii) at least 35 wt-%, based on the total weight of the powderous formulation, of the precipitated silica, and
(iv) 0 to 10 wt-%, based on the total weight of the powderous formulation, of water and/or an additive.

6. The water dispersible powderous formulation according to claim 1 , wherein n is an integer between 3 and 9 and R 1 is OH, COOH or —ONO 2 .

7. The water dispersible powderous formulation according to claim 1 , wherein the compound of formula (I) is selected from the group consisting of 3 nitrooxypropanol, 9 nitrooxynonanol, 5 nitrooxy pentanoic acid, 6 nitrooxy hexanoic acid, bis(2 hydroxyethyl)amine dinitrate, 1,4-bis-nitrooxybutane and 1,5-bis-nitrooxypentane.

8. The water dispersible powderous formulation according to claim 1 , wherein the edible oil is selected from the group consisting of propyleneglycol, corn oil, rapeseed oil, sunflower oil, middle chain triglyceride, glycerol and mixtures thereof.

9. The water dispersible powderous formulation according to claim 1 , wherein the edible oil is propyleneglycol.

10. The water dispersible powderous formulation according to claim 1 consisting of:
(i) 2 to 15 wt-%, based on the total weight of the powderous formulation, of 3-nitrooxypropanol,
(ii) 20 to 40 wt-%, based on the total weight of the powderous formulation, of propyleneglycol,
(iii) at least 38 wt-%, based on the total weight of the powderous formulation, of the precipitated silica, and
(iv) 0 to 7 wt-%, based on the total weight of the powderous formulation, of water.

11. The water dispersible powderous formulation according to claim 1 , wherein the particle size D(v, 0.5) of the precipitated silica is in a range of 200 μm to 400 μm.

12. The water dispersible powderous formulation according to claim 1 , wherein the powderous formulation contains an additional coating.

13. The water dispersible powderous formulation according to claim 12 , wherein the coating is selected from the group consisting of glycerine monostearate, carnauba wax, candelilla wax, sugarcane wax, palmitic acid, stearic acid hydrogenated cottonseed oil, hydrogenated palm oil, hydrogenated rapeseed oil and mixtures thereof.

14. The water dispersible powderous formulation according to claim 1 , wherein R 8 is 2-pyridyl.

15. An aqueous dispersion which comprises water and the powderous formulation according to claim 1 dispersed in the water.

16. A feed product comprising the aqueous dispersion according to claim 15 .

17. A feed product comprising the powderous formulation according to claim 1 .

Assignees

• Dsm Ip Assets Bv

Inventors

• Brunner Dominik Josef
• Clasadonte Laure
• Gothscheck Christine
• Vidoni Olivia Brigitte
• Wollgast Silvia Maria

Classifications

• Y02P60/50

  Livestock or poultry management · CPC title

• A23K50/10

  for ruminants · CPC title

• A23K40/30

  by encapsulating; by coating · CPC title

• A23K40/10

  by agglomeration; by granulation, e.g. making powders · CPC title

• A23K20/28

  Silicates, e.g. perlites, zeolites or bentonites · CPC title