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Use of RNA for reprogramming somatic cells
US11008550B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11008550-B2 |
| Application number | US-201916250366-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 17, 2019 |
| Priority date | Dec 14, 2007 |
| Publication date | May 18, 2021 |
| Grant date | May 18, 2021 |
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- Title
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Abstract
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The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically, the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in particular pluripotency, by introducing RNA encoding factors inducing the de-differentiation of somatic cells into the somatic cells and culturing the somatic cells allowing the cells to de-differentiate.
First claim
Opening claim text (preview).
The invention claimed is: 1. A RNA-transfected somatic cell population which comprises somatic cells subjected to electroporation, containing in vitro transcribed mRNA encoding OCT4, SOX2, KLF4 and c-MYC, wherein the 5′-Cap of said mRNA consists of the D1 isomer of m 2 7,2′-0 GppspG and wherein the transfected cell population expresses alkaline phosphatase and expresses endogenous OCT4, for at least 7 days. 2. The RNA-transfected somatic cell population in accordance with claim 1 wherein the somatic cells are human cells. 3. The RNA-transfected somatic cell population in accordance with claim 2 wherein the human cells are adult human dermal fibroblasts. 4. The RNA transfected somatic cell population in accordance with claim 1 wherein the somatic cells are fibroblasts.
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Inventors
Classifications
- C12N5/0696Primary
Artificially induced pluripotent stem cells, e.g. iPS · CPC title
Genetically modified cells · CPC title
Sox-2 · CPC title
Klf-4 · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
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- What does patent US11008550B2 cover?
- The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically, the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in particular pluripotency, by introducing RNA encoding factors inducing the de-differentiation of somatic…
- Who is the assignee on this patent?
- Biontech Ag, Tron—Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnutzige Gmb, BioNTech SE, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0696. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 18 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).