Boron-containing small molecules

Patent metadata

Field	Value
Publication number	US-11008345-B2
Application number	US-201916526248-A
Country	US
Kind code	B2
Filing date	Jul 30, 2019
Priority date	Sep 7, 2010
Publication date	May 18, 2021
Grant date	May 18, 2021

Abstract

This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.

First claim

What is claimed is:

1. A compound having a structure which is:

wherein R 3 is —CH 2 NH 2 ;
R 4 is selected from the group consisting of halogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, and sec-butoxy;
Y is O; and
R 5 is

wherein a is 2, 3 or 4;
R 10 and R 11 is H; and
R 12 is selected from the group consisting of H, OH, NH 2 , methyl, ethyl, —NHS(O) 2 CH 3 , cyano, —NHC(O)CH 3 , —NHC(O)NHCH 2 CH 3 , —C(O)NH 2 , —C(O)OH, 4-(methoxy)phenyl, benzyl, benzoxy, —NHC(O)OCH 2 Ph, —C(O)NHCH 2 CH 2 OH and —C(NH 2 )(NH);

or a salt, hydrate or solvate thereof.

Assignees

• Anacor Pharmaceuticals Inc

Inventors

• Hernandez Vincent S
• Ding Charles
• Plattner Jacob J
• Alley Michael Richard Kevin
• Rock Fernando
• Zhang Suoming
• Easom Eric
• Li Xianfeng
• Zhou Ding

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61K31/69 Primary

  Boron compounds · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61P31/06

  for tuberculosis · CPC title