Glucosylceramide synthase inhibitors

US11008316B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-11008316-B2
Application numberUS-201715490385-A
CountryUS
Kind codeB2
Filing dateApr 18, 2017
Priority dateSep 11, 2012
Publication dateMay 18, 2021
Grant dateMay 18, 2021

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

    Technology tags used to group this patent with similar filings.

  7. Citations and related patents

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Abstract

Official abstract text for this publication.

The invention relates to inhibitors of glucosylceramide synthase (GCS), such as Compound of Formula I, shown below, as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

First claim

Opening claim text (preview).

The invention claimed is: 1. A compound of the formula or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 and at least one pharmaceutically acceptable carrier.

Assignees

Inventors

Classifications

  • Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title

  • A61K31/439Primary

    the ring forming part of a bridged ring system, e.g. quinuclidine (8-azabicyclo [3.2.1] octanes A61K31/46) · CPC title

  • containing further heterocyclic rings · CPC title

  • having two nitrogen atoms, e.g. dilazep · CPC title

  • C07D453/02Primary

    containing not further condensed quinuclidine ring systems · CPC title

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Frequently asked questions

Answers are generated from the same data shown on this page.

What does patent US11008316B2 cover?
The invention relates to inhibitors of glucosylceramide synthase (GCS), such as Compound of Formula I, shown below, as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
Who is the assignee on this patent?
Genzyme Corp
What technology area does this patent fall under?
Primary CPC classification A61K31/439. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue May 18 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).