Quinuclidinone analogues as anticancer agents
US-2024217964-A1 · Jul 4, 2024 · US
US11008316B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11008316-B2 |
| Application number | US-201715490385-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 18, 2017 |
| Priority date | Sep 11, 2012 |
| Publication date | May 18, 2021 |
| Grant date | May 18, 2021 |
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The invention relates to inhibitors of glucosylceramide synthase (GCS), such as Compound of Formula I, shown below, as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
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The invention claimed is: 1. A compound of the formula or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 and at least one pharmaceutically acceptable carrier.
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title
the ring forming part of a bridged ring system, e.g. quinuclidine (8-azabicyclo [3.2.1] octanes A61K31/46) · CPC title
containing further heterocyclic rings · CPC title
having two nitrogen atoms, e.g. dilazep · CPC title
containing not further condensed quinuclidine ring systems · CPC title
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